Glutamine and the Brain

[Predaking]

Do large doses of glutamine have any positive/negative nootropic effects?

[repmks]

idk but there are some people on youtube claiming it is toxic. like this [ame="http://www.youtube.com/watch?v=ExyNf3u7iQg"]YouTube - Why " MUSCLE MILK " Is A Neuro-Toxic Soup Of Processed Crap! ufc wec mma[/ame]


i think this guy doesn't what he is talking about. i hope someone has more to add on this topic since we consume mass amounts of glatamic acid via protein shakes.

[FlexW99]

Like I mentioned in another post: I don't 'feel' any difference on it or off it. I still take it since its been a staple of mine for years. I ingest 10g/day.

I dont buy the neuro-toxicity complaint, in fact, that guy needs to drink some muscle milk and put some mass on those bones.

It can't be more toxic than people who ingest pills everyday, or drink high levels of alchohol; I'd be more concerned about the latter than L-Glutamine.

[Predaking]

What if you took 50g?

[FlexW99]

What if you took 50g?

I dunno. I would think that, like anything else, if your body doesn't need it, it excretes it through urine.

50G day is overkill if your natural. I would think bodyweight or more specifically muscleweight would also be a factor.

This is just a hunch, I have no proof or backup.

[pmiller383]

Glutamine is only going to produce a noticeable nootropic if your are deficient in glutamate. Since Glutamate is the most abundant excitatory neurotransmitter in humans, it is doubtful that you are going to be deficient. If your looking for a nootropic boost from the glutamine family, check out pyroglutamic acid. It helps increase oxygen in the brain and preserves the brains stores of ACh.

[FlexW99]

Glutamine is only going to produce a noticeable nootropic if your are deficient in glutamate. Since Glutamate is the most abundant excitatory neurotransmitter in humans, it is doubtful that you are going to be deficient. If your looking for a nootropic boost from the glutamine family, check out pyroglutamic acid. It helps increase oxygen in the brain and preserves the brains stores of ACh.

What he said! lol

:dl:

[cmc]

idk but there are some people on youtube claiming it is toxic. like this http://www.youtube.com/watch?v=ExyNf3u7iQg


i think this guy doesn't what he is talking about. i hope someone has more to add on this topic since we consume mass amounts of glatamic acid via protein shakes.

I made a post about this not to long ago, not sure what forum topic it was under. I havnt watched the vid yet but what i had posted was in reference to glutamine. Dr. Colgan of the Colgan Institute (google them) has found out that if you use glutamine, you are whacking your body with ammonia. Dry glutamine powder degrades into ammonia and pyroglutamic acid, wehther absorbed into a liquid solution and even in your stomach. Thats it in a nutshell. Instead, use ornithine and alpha-ketoglutarate. Both are ammonia scavengers and will produce a readily supply of glutamine within the body.

Im sure there may be opposing articles out there yet the Colgan Institute has been testing athletes for many years along with all forms of nutrition and supplements.

[TexasTitan]

I made a post about this not to long ago, not sure what forum topic it was under. I havnt watched the vid yet but what i had posted was in reference to glutamine. Dr. Colgan of the Colgan Institute (google them) has found out that if you use glutamine, you are whacking your body with ammonia. Dry glutamine powder degrades into ammonia and pyroglutamic acid, wehther absorbed into a liquid solution and even in your stomach. Thats it in a nutshell. Instead, use ornithine and alpha-ketoglutarate. Both are ammonia scavengers and will produce a readily supply of glutamine within the body.

Im sure there may be opposing articles out there yet the Colgan Institute has been testing athletes for many years along with all forms of nutrition and supplements.

So to sum it up, use ornithine and alpha-ketoglutarate. Could you elaborate as far as dosages and the exact differences between the two. I mean should they only be used together, are they worth doubling up? Is taking one just fine? I realize thats a lot of questions but you seem you know your buisness.

[cmc]

So to sum it up, use ornithine and alpha-ketoglutarate. Could you elaborate as far as dosages and the exact differences between the two. I mean should they only be used together, are they worth doubling up? Is taking one just fine? I realize thats a lot of questions but you seem you know your buisness.

The info I gave you was from a nutrition book that I have, I only know what I read..lol. Let me take a gander and report back. Ok..it states that for maximum anabolism, each meal should include 2-4 grams of ornithine alpha-ketoglutarate. In addition, each post exercise meal should include 2-4 grams of ketoisocaproate.

The combination of ketoisocaproate form of leucine with the ornithine alpha-ketoglutarate forms or ornithine and glutamine should provide the most anabolicand anti catabolic mix of these amino acids known to science (the book is a few years old but solid--keep that in mind).

If I can find a scanner in the next few days or week..Ill scan the few pages and upload them. It does go into great detail, Ill see what I can do to get this info up here. Im not a great typer....lol.

Maybe try googling or searching some stores for those forms and see what you can come up with.

[DerickVonD]

Some people are more sensitive to MSG or processed gluten than others. I myself am very sensitive and will have panic attacks if I have processed gluten. Ibuprofen I read blocks gluten toxicity, so that's what I use when I have an attack. I really works for the headaches. There is a ton of info on this topic at thetruthinlabeling.org. They even had a 60 minutes segment on msg (same thing as processed unbound gluten) in 1994 or 92 cant remember the year. it's on youtube and i posted it in another topic awhile ago.

[MrBigPR]

Like I mentioned in another post: I don't 'feel' any difference on it or off it. I still take it since its been a staple of mine for years. I ingest 10g/day.

I dont buy the neuro-toxicity complaint, in fact, that guy needs to drink some muscle milk and put some mass on those bones.

It can't be more toxic than people who ingest pills everyday, or drink high levels of alchohol; I'd be more concerned about the latter than L-Glutamine.

Why do you still take it if you dont "feel" any different on or off? Seems like a waste of money to me. Especially when you can get Glutamine in ON whey protein and Xtend.

[allstar504448]

Glutamine is only going to produce a noticeable nootropic if your are deficient in glutamate. Since Glutamate is the most abundant excitatory neurotransmitter in humans, it is doubtful that you are going to be deficient. If your looking for a nootropic boost from the glutamine family, check out pyroglutamic acid. It helps increase oxygen in the brain and preserves the brains stores of ACh.

wikipedia gave me the following when i instinctively typed in "ach brain" into google lol:
"The chemical compound acetylcholine (often abbreviated ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the somatic nervous system. It is also the neurotransmitter in all autonomic ganglia."

i, however, made no sense of it

[pmiller383]

Alright,simply Acetylcholine is released by your nerves to tell your muscles to contract. In the brain it is believed to be important for learning and memory among other things.

[allstar504448]

can it be supplemented?
if it can be, it sounds risky at best

[pmiller383]

can it be supplemented?
if it can be, it sounds risky at best

You can supplement with choline, but your body limits the amount of Ach by preventing uptaking of the choline into your nerves. Its only going to make a difference if your deficient or possibly if you are in a situation where you need higher amounts of choline to synthesize into Ach. Ach is made from dietary choline intake and B-5 (I believe) so its not like its some crazy chemical that you can only get by injecting it in you @ss lol. How does it sound risky to you? I should also mention that once Ach binds with protein receptor at the muscular nerve it is broken down by acetylcholinesterase AchE, so the only thing that would be risky IMO is taking a AchE inhibitor (which I don't think anyone is going to do) If you ever want to see the effects of an AchE inhibitor, spray DDT bug spray on an insect. You will notice the bug tenses up completely and then dies, thanks to all that Ach not being broken down.

[allstar504448]

i have nooooooooooooo knowledge at all on the subject, just when it comes to dealing with the brain i'm a little hesistant is all. i dont think im deficient, so ill definitely avoid this deal

[immastBreesee]

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