Creatine Ethyl Ester DEBUNKED (again)

  1. Exclamation Creatine Ethyl Ester DEBUNKED (again)


    Hi friends. I don't post much here anymore, but thought I'd share some of the latest in the world of sport nutrition science. Visit Journal of the International Society of Sports Nutrition for more information.

    The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels

    This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE. Serum creatinine was greater in CEE compared to the PLA (p = 0.001) and CRT (p = 0.001) and increased at days 6, 27, and 48. Total muscle creatine content was significantly higher in CRT (p = 0.026) and CEE (p = 0.041) compared to PLA, with no differences between CRT and CEE. Significant changes over time were observed for body composition, body water, muscle strength and power variables, but no significant differences were observed between groups. In conclusion, when compared to creatine monohydrate, creatine ethyl ester was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power. Therefore, the improvements in these variables can most likely be attributed to the training protocol itself, rather than the supplementation regimen.


  2. Furthermore, esterified creatine is unstable in low pH
    conditions (14,15), and has been shown to be rapidly degraded to creatinine in stomach
    acid (16).
    Really makes me glad for sticking with simple monohydrate my whole life simply because it was cheaper....

    Anyways, great find man

  3. Figured this would play out in the data at some point. I've felt the same thing on mono vs CEE even though I don't respond as well to creatine molecules as most others.

    I've always recommended noons to start on mono because of both cost and the research behind it.

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  4. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE.
    Higher creatine levels in the placebo group (i.e. maltodextrose) vs CEE group.... Are they contradicting themselves here?

  5. I think I posted something like that few months ago already.

  6. Quote Originally Posted by Steveoph View Post
    Higher creatine levels in the placebo group (i.e. maltodextrose) vs CEE group.... Are they contradicting themselves here?
    2nd creatine study I've seen this month to cause controversy over the results of placebo.

    Steveo, will Nutra be getting bulk placebo in any time soon???
  

  
 

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