Glucosamine causes insulin resistance

  1. Glucosamine causes insulin resistance

    Hi Guys,
    I have no scientific background, so maybe someone more knowledgeable could comment. These studies seem to show that taking glucosamine is very counter-productive as it blocks glucose uptake in muscle, among other things. So it would kill the effects of carbs for PWO, and maybe muscle glycogen replenishment?

    Sorry, I still don't have enough posts to be allowed to post links, so you will have to google Glucosamine and insulin to see the info.

    Glucosamine hydrochloride seems to have about a 2 1/2 hour half-life, but lower levels may hang around in the body for a LONG time. Some forms have a much longer half-life.

    Anyway, I am sticking with Cissus after this.

  2. i would say it MAY be possible in extreme doses in empty stomach. after all it is derived from glucose i believe.

    i wouldnt be too worried about it to be honest,

    theres also studies on chondrioten and BPH.

    none of the eveidence is actually saying it DOES cause.
  3. Never enough
    EasyEJL's Avatar

    A review conducted by Anderson et al in 2005 summarizes the effects of glucosamine on glucose metabolism in in vitro studies, the effects of oral administration of large doses of glucosamine in animals and the effects of glucosamine supplementation with normal recommended dosages in humans, concluding that glucosamine does not cause glucose intolerance and has no documented effects on glucose metabolism.[14] Other studies conducted in lean or obese subjects concluded that oral glucosamine at standard doses does not cause or significantly worsen insulin resistance or endothelial dysfunction
    ^ Anderson J.W., Nicolosi R.J., Borzelleca J.F. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food and Chemical Toxicology. 2005; 43 (2): 187- 201
    ^ Muniyappa R., Kame R.J., Hall G., Grandon S.K., Bronstein J.A., Ver M.R, Hortin G.L., Quon M.J. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes. 2006; 55 (11): 3142-50.
    ^ Powels M., Jacobs J.R., Span P.N., Lutterman J.A., Smits P., Tack C.J. Short – term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab. 2001; 86:2099-2103.
    ^ Biggee B., Blinn C.M., Nuite M., Sibert J.E., Mc Alindon T.E. Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis. Ann Rheum Dis. 2007, 66 (2): 260-262.
    Animis Rep

  4. Thanks guys. I did a bit more reading and you're right, it only adversely affects those who already have insulin-resistance problems, so it may be a no-no for diabetics, for example.
    Guess I'll continue with 1500mg. per day, as it does seem to keep the joint pain down.
  5. Never enough
    EasyEJL's Avatar

    its generally possible to find conflicting studies on ANYTHING, so go with what feels good
    Animis Rep


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