Effects of too much glutamine?
12-06-2003 12:46 AM
Effects of too much glutamine?
Having used the search button, like a good little newbie, I can see how much... um... "discussion" shall we say, there is surrounding glutamine.
To take or not to take, seems to have been the question of a multitude of threads, all of which end in bickering.
This being the case, I'm reluctant to start yet another one, but I want an answer to my question! So let me first state my impartiality... I am taking glutamine because it comes in my protein shakes - not because I have an opinion on its worth one way or another!
Now - the question...
I recently discovered that Leppin's "PRO4 Protein Matrix" ( ) which I use as a MRP has 8g glutamine per serve. Yippee, I thought - until I realised that two or three serves of it would put me at 16-24g each day.
And that's before I count my post-workout protein, which also contains glutamine... So another 5g on top of that brings me to a total of 21-29g of glutamine each day!
Now, I'm not absolutely convinced that Leppin have got it right - although they mention glutamine as an ingedient on the container, the only place they've given the actual amount is in the blurb on their website... I would have thought if it really contained that much glutamine, they'd have been promoting that fact like crazy!
So I've sent them an email, asking them to clarify this - no response as yet.
But IF their website is correct, that would give me a LOT of glutamine each day! Does anyone know how much is too much, and if there are any problems with such an overdose?
12-06-2003 12:56 AM
You won't overdose on it. If you have extra you will just excrete it in your urine.
12-06-2003 02:15 AM
I am faster than 80% of all snakes
Not urine. Its more through bowel movements and gas. Its the same reaciton you will get when taking in too much fast acting protein.
12-06-2003 12:14 PM
12-06-2003 06:02 PM
Well, that doesn't sound too bad...
The guy at my supplements store (and I think he's generally pretty clued up) was saying he thought too much glutamine could increase your ammonia levels.
But no-one's heard of this happening, then?
12-06-2003 07:40 PM
My opinion as well, prolang. IMO, glutamine is a waste of cash, period. Originally posted by theprolangtum A thinner wallet
12-07-2003 11:19 AM
If it comes with your MRP , then by all means is not bad . Glutamine is an essential amino acid. Anything that isn't used by the body will be exreted, although a lot of it is used in the gut and cells of the intestine walls. Might help you with recovery in the long term.
12-07-2003 01:18 PM
Doesnt glutamine increase amonia in the body?
12-07-2003 03:39 PM
Amonia? I don't think so. Amonia is a byproduct excreted from protein but from glutamine , idon't think so
12-08-2003 04:59 PM
Well, after extensive searching, I've discovered that 4g of glutamine a day can help cure irritable bowel syndrome. (http://www.lihealth.com/_supp.htm#glutamine)
Not immediately useful to me, perhaps, but I'll bear it in mind...
The other useful page I found was http://www.geocities.com/HotSprings/...glutamine.html
It summarises the studies done on glutamine, and would seem to be fairly impartial. It says disadvantages include:
No mention of it increasing ammonia levels, or the RDI for glutamine, though... Does anyone know this?
* Research has indicated that glutamine supplementation is safe for humans (21). However, there is little data regarding long-term usage (more than a few weeks) of glutamine supplements Furthermore, more research needs to be conducted to investigate the safety of glutamine supplementation at doses that are posited to promote nitrogen retention in the muscles.
* Generally speaking, the consumption of any one, single amino acid in large doses may inhibit the absorption of other amino acids since amino acids (basic and neutral amino acids) tend to compete for transport across the intestinal epithelium. However, a study performed by Dechelotte et al. reported that glutamine is absorbed effectively in the small intestine (22).
* The consumption of large doses of free amino acids may result in intestinal discomfort (e.g. abdominal pains and diarrhea) due to the electrolyte-like properties of the amino-acids.
12-09-2003 12:23 PM
Didn't make a difference for me at 30 grams while cutting. Felt like I was robbed.
12-09-2003 08:58 PM
What were you expecting to see, IronWarrior? Or rather, what didn't you see?
I got a reply from Leppin the other day. This is how the conversation went, in case anyone's interested...
This doesn't prove an awful lot one way or another, but I thought you guys might be interested. Hi there -
I notice that you say "PRO4 has 8 grams of Glutamine per serve with added BCAA's." This seems like an lot of glutamine - is it correct?!
Yes based on what each protein (whey concentrate/isolate/casinate/ablbimum) contains Since I'm taking 2-3 serves per day, would this be too much glutamine? I was under the impression that if you took over ~12g, the body started producing ammonia.
That will be fine, some rugby players are using up to 20 gms a day, it really depeands on what you are training for ? I'm bodybuilding frantically for a competition next year!
By the time I've had 2-3 servs of PRO4, plus a post-workout protein, I'd be getting up to 29g glutamine a day... This does seem like an awful lot - do you know of any problems with taking so much?
Its similar to what i consume but i use a mix of our Ultimate whey and Pro-4 protein so am getting about 20-30 gms a day over the space of 3-4 meals from shakes........no noticelabe side effects other than my recovery seems to be a bit better ?
12-10-2003 01:55 PM
there is a huge debate over at bb.com about glutamine being a ****e product...whart are your thoughts on that?
12-10-2003 04:17 PM
Glutamic acid has the ability to absorb ammonia and convert it to the buffer glutamine. Low levels of glutamine=low levels of glutamic acid. So in essence it will help reduce levels of ammonia.
12-10-2003 04:55 PM
Originally posted by RaulJimenez Amonia? I don't think so. Amonia is a byproduct excreted from protein but from glutamine , idon't think so
I had read or misread it in a book. Let me see if I still have the book and I will try to find it. Tonight or tomorrow. Originally posted by shadow warrior Glutamic acid has the ability to absorb ammonia and convert it to the buffer glutamine. Low levels of glutamine=low levels of glutamic acid. So in essence it will help reduce levels of ammonia.
12-10-2003 10:48 PM
12-11-2003 07:30 PM
Yep I had misread it. It did say a side effect was consipation though. Originally posted by dito I had read or misread it in a book. Let me see if I still have the book and I will try to find it. Tonight or tomorrow.
12-12-2003 07:12 PM
It did not help me preserve any more muscle mass while cutting compared to cutting without glutamine. I used it for almost 2 months. Boy I was much dumber back then Originally posted by Aitaronz What were you expecting to see, IronWarrior? Or rather, what didn't you see?
12-14-2003 12:06 PM
Damn, I take in 45 grams of glutamine a day and am noticing extremely good results while cutting. I never even thought twice that this could lead to problems...i'm still not convinced 45 grams a day will, though!
12-14-2003 04:42 PM
The question is... does it make any difference? I get pretty good results from eating though Originally posted by Toneyfan Damn, I take in 45 grams of glutamine a day and am noticing extremely good results while cutting. I never even thought twice that this could lead to problems...i'm still not convinced 45 grams a day will, though!
Similar Forum Threads
By qwerty33 in forum Supplements
Last Post: 11-30-2009, 02:09 PM
By JDRG in forum Supplements
Last Post: 02-07-2009, 06:38 PM
By ArnoldIsMyIdol in forum Supplements
Last Post: 09-12-2008, 10:37 PM
By Fun2Train in forum Supplements
Last Post: 01-05-2007, 07:49 PM
By biggun2181 in forum Supplements
Last Post: 06-03-2005, 08:05 PM