Decreasing effectiveness of caffeine
- 01-26-2009, 09:35 AM
- 01-26-2009, 09:45 AM
good question. i would say fat burning is diminished as well, but that's just a complete guess. I know that if you've developed a tolerance to caffeine it does not boost performance in the gym.
- 01-26-2009, 10:28 AM
i think it diminishes over time i believe caffeine works on beta receptors (not 100% sure tho) and they diminish quickly.
01-26-2009, 04:41 PM
I think it would just be the cognitive part that decreases for the most part. Caffeine will increase the amount of fat used as fuel for the muscles during extended periods of exercising. I don't think the body would build up a tolerance on that side but as long as you don't abuse it and you cycle it a bit I would think the overall tolerance for it would be minimal.
01-26-2009, 10:35 PM
01-26-2009, 10:37 PM
01-27-2009, 12:18 PM
Most of the biological actions of caffeine are possibly mediated through its antagonistic effects to adenosine. Adenosine activates an inhibitory GTP-binding protein (Gi). One of the physiological actions of Gi is the inhibition of cAMP formation. Caffeine overcomes this action thus leading to elevation of cAMP. Firing of neurons and the release of neurotransmitters is also inhibited by adenosine. Caffeine overcomes this effect, thus producing increased CNS-activity.
During long term administration of caffeine (especially high doses) many functions of the body develop tolerance including cardiovascular and central nervous systems. Present research suggests that caffeine tolerance following continuous, high doses coffee ingestion is the response of the body against caffeine through the upregulation of adenosine receptors.
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