Glut4 Transcription supplements

[Whacked]

I am having a difficult time locating any evidence whereby glut4 is preferentially activated in muscle vs adipose tissue.

If all the popular glut4 supps also agonize/increase expression in fat cells, to uptake glucose then what's the appeal?

Thanks

 

[JudoJosh]

To my knowledge, none specifically target only muscle.

 

[Whacked]

Thanks Judo.

So help me out here. What's the appealing attribute?

Less insulin release? Therefore one can curtail insulinogenic-related response and the correlating sides (lethargy, etc)? Still though; where is the evidence these products have any distinct lipolytic advantage when someone ingests carbs?

 

[Whacked]

Insulin is obviously lipogenic and anti-lipolytic so is this perhaps the appeal as well? To quell insulin response thus not allowing insulin to thwart lipolysis?

 

[JudoJosh]

I think most approach it thinking the body has a hierarchy for storage. So up to a point, all nutrients are going to go to other places first (brain, organs, muscles, etc) with adipose tissue being the last place. So if you are in a slight caloric surplus then the extra nutrients are going to be shuttled to your muscles but if you are in a huge surplus, like taking a GDA and them binge eating, then after everything else gets their fill those nutrients are going to be shuttled to adipose.

Some GDAs, such as recompadrol, add compounds in to try and prevent adipose differentiation so to limit this. RecompMan will prolly be able to shed some light on this far better than I. I am kinda just thinking out loud here.

 

[Whacked]

Thanks man

 

[kdubson14]

Don't taurine and agmatine increase glut-4 translocation and expression in skeletal muscle only?

 

[DieselNY]

The GDA product I use has fenugreek which is a popular glut4 supplement.

 

[Whacked]

Don't taurine and agmatine increase glut-4 translocation and expression in skeletal muscle only?

I sure would love to know.

 

[machinehead]

Can't post links so

ncbi.nlm.nih.gov/pubmed/20522594

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

 

[kbayne]

Can't post links so

ncbi.nlm.nih.gov/pubmed/20522594

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

TUDCA is one of the only ones I know of but you need an extremely high dose (1750mg I believe was used in the study) and that would be very very expensive.

 

[Whacked]

Berberine

http://m.diabetes.diabetesjournals.org/content/55/8/2256.full

Although there are some important caveats here: http://examine.com/supplements/Berberine/