In recent months I have been in a very toxic work environment as well as challenged with many material/property/money issues. I had continued my regular cardio and resistance training as usual but experienced some anxiety from the stress.
To make matters worse, I tore my right bicep tendon and had repair surgery (May 1st), so my baseball and weight lifting days are on hold for a good long time. They had been an outlet for much of my stress and frustrations as well as an alternative outlet for a previous substance abuse issues some many years ago. To further increase my stress and subsequent anxiety to the breaking point - I was laid off May 27th.
During those periods of acute stress I experienced anxiety attacks with symptoms or elevated BP (140's/80's), rapid heart rate (80's BPM) as well as irregular heart beat and palpitations. I had done some research and I for the most part was relieved to find that it is not uncommon for someone with my triggers and exposures to experience stress induced elevated BP/HR, heart arrhythmia, anxiety attacks, etc. I recognized the triggers and eliminated other triggers like stimulants, alcohol, etc.
But to be honest the lay-off, at the presentation from HR, sent me into a severe (for me anyway) anxiety attack with rapid HR, elevated BP and palpitations and arrhythmia. It took me three plus hours to calms down. I am for the most part am very healthy and had even recently see a cardiologist at my annual physical and did a stress test, electrocardiogram as well as a heart ultra-sound. My resting HR is normally at about 60BPM and can be as low as the very low 50's when well conditioned. My normal BP is 120±5/70±5, often on the low end when very conditioned and often at the higher end when less conditioned and as I have aged. My exam revealed my BP and HR were normal and my heart and valves are normal and healthy for my age.
So aside from these factors above I came across some information recently regarding "GABA-ergic anxiety" and having appreciated what I found I remembered I had some NP's bulk GABA in my cupboards and just began to take some at 500mg two to four times a day. In the last couple days I have noticed a reduction in the overall unwell feeling I have recently been feeling. Granted I just found a new job yesterday so I am sure that there is some correlation but honestly this has been an issue for a while before only to become chronically acute after the layoff one month ago.
I can appreciate placebo effects as well as the understanding that GABA in supplement form has blood/brain barrier issues. Anecdotally, honestly, as I am writing this I am experiencing a calm from 500mg of GABA which I just took empty stomach just 10 mins before composing this post.
The two articles below kind of shed some light on the issue (aside from the EQ as it is not relevant in my case).
The role of GABA in anxiety disorders.
Lydiard RB.
Author information
Abstract
Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders.
PMID:
12662130
[PubMed - indexed for MEDLINE]
"Anxiety is felt to be related to GABA-ergic transmission in the brain. For some time, it has been known that some steroids, particularly boldenone (Equipoise - boldenone undecylenate - ) and stanazolol (Winstrol - stanozolol), affect GABA receptors in the brain. GABA is considered predominantly inhibitory, i.e. a "chiller". Equipoise - boldenone undecylenate - can strip the brain of its natural chillers, GABA, creating waves of panic as you experience and describe so eloquently. Some people are born without sufficient GABA-ergic transmission, predisposing them to panic attacks such as you experienced, but in the absence of any externally administered drug. If you external stress overrides your GABA-ergic transmission, you will panic. So some only develop panic after a traumatic event. You probably had sufficient GABA-ergic transmssion for everyday life, but you were closer to that critical line than you thought, so when Equipoise - boldenone undecylenate - stripped your GABA, you were pushed over that edge into panic. Some people are very far from that edge, so they can take a gram or two of Equipoise - boldenone undecylenate - , strip their receptors, and still have no problems. Treatment options include benzos (which directly enhance GABA-ergic transmission, but have terrible tolerance and addiction potential and are NOT recommended), antidepressants (which by influencing serotonin and norepinephrine can enhance GABA-ergic transmission or simply screen more external stress through their mechanisms), and lastly DON"T DO Equipoise - boldenone undecylenate - . This last one is simplest and best of course."
So, I would like to hear any input form those who are educated in the area of brain chemistry, chronic acute stress and in regard to GABA in it's role in anxiety and/or any other support supplements and their role in treating anxiety. I apologize for the long winded post but I wanted to provide some history for insight and accurate assessment for those who may be helpful.
Thanks in advance,
Your friendly neighborhood MOD
To make matters worse, I tore my right bicep tendon and had repair surgery (May 1st), so my baseball and weight lifting days are on hold for a good long time. They had been an outlet for much of my stress and frustrations as well as an alternative outlet for a previous substance abuse issues some many years ago. To further increase my stress and subsequent anxiety to the breaking point - I was laid off May 27th.
During those periods of acute stress I experienced anxiety attacks with symptoms or elevated BP (140's/80's), rapid heart rate (80's BPM) as well as irregular heart beat and palpitations. I had done some research and I for the most part was relieved to find that it is not uncommon for someone with my triggers and exposures to experience stress induced elevated BP/HR, heart arrhythmia, anxiety attacks, etc. I recognized the triggers and eliminated other triggers like stimulants, alcohol, etc.
But to be honest the lay-off, at the presentation from HR, sent me into a severe (for me anyway) anxiety attack with rapid HR, elevated BP and palpitations and arrhythmia. It took me three plus hours to calms down. I am for the most part am very healthy and had even recently see a cardiologist at my annual physical and did a stress test, electrocardiogram as well as a heart ultra-sound. My resting HR is normally at about 60BPM and can be as low as the very low 50's when well conditioned. My normal BP is 120±5/70±5, often on the low end when very conditioned and often at the higher end when less conditioned and as I have aged. My exam revealed my BP and HR were normal and my heart and valves are normal and healthy for my age.
So aside from these factors above I came across some information recently regarding "GABA-ergic anxiety" and having appreciated what I found I remembered I had some NP's bulk GABA in my cupboards and just began to take some at 500mg two to four times a day. In the last couple days I have noticed a reduction in the overall unwell feeling I have recently been feeling. Granted I just found a new job yesterday so I am sure that there is some correlation but honestly this has been an issue for a while before only to become chronically acute after the layoff one month ago.
I can appreciate placebo effects as well as the understanding that GABA in supplement form has blood/brain barrier issues. Anecdotally, honestly, as I am writing this I am experiencing a calm from 500mg of GABA which I just took empty stomach just 10 mins before composing this post.
The two articles below kind of shed some light on the issue (aside from the EQ as it is not relevant in my case).
The role of GABA in anxiety disorders.
Lydiard RB.
Author information
Abstract
Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders.
PMID:
12662130
[PubMed - indexed for MEDLINE]
"Anxiety is felt to be related to GABA-ergic transmission in the brain. For some time, it has been known that some steroids, particularly boldenone (Equipoise - boldenone undecylenate - ) and stanazolol (Winstrol - stanozolol), affect GABA receptors in the brain. GABA is considered predominantly inhibitory, i.e. a "chiller". Equipoise - boldenone undecylenate - can strip the brain of its natural chillers, GABA, creating waves of panic as you experience and describe so eloquently. Some people are born without sufficient GABA-ergic transmission, predisposing them to panic attacks such as you experienced, but in the absence of any externally administered drug. If you external stress overrides your GABA-ergic transmission, you will panic. So some only develop panic after a traumatic event. You probably had sufficient GABA-ergic transmssion for everyday life, but you were closer to that critical line than you thought, so when Equipoise - boldenone undecylenate - stripped your GABA, you were pushed over that edge into panic. Some people are very far from that edge, so they can take a gram or two of Equipoise - boldenone undecylenate - , strip their receptors, and still have no problems. Treatment options include benzos (which directly enhance GABA-ergic transmission, but have terrible tolerance and addiction potential and are NOT recommended), antidepressants (which by influencing serotonin and norepinephrine can enhance GABA-ergic transmission or simply screen more external stress through their mechanisms), and lastly DON"T DO Equipoise - boldenone undecylenate - . This last one is simplest and best of course."
So, I would like to hear any input form those who are educated in the area of brain chemistry, chronic acute stress and in regard to GABA in it's role in anxiety and/or any other support supplements and their role in treating anxiety. I apologize for the long winded post but I wanted to provide some history for insight and accurate assessment for those who may be helpful.
Thanks in advance,
Your friendly neighborhood MOD