Sulforaphane Inhibits Myostatin?

  1. Senior Member
    The Engineer's Avatar
    Stats
    5'9"  160 lbs.
    Join Date
    Jun 2013
    Posts
    1,182
    Rep Power
    399816
    Level
    37
    Lv. Percent
    58.1%
    Achievements Activity ProPosting Pro

    Sulforaphane Inhibits Myostatin?


    From ergo-log:
    Cauliflower, broccoli & bodybuilders

    If we were to do some anecdotal testing of our own using Swanson's Sulforaphane (Swanson GreenFoods Formulas Sulforaphane from Broccoli - 100% Natural 400 mcg 60 Veg Caps - Swanson Health Products) what would be the necessary dose required to recreate the tests?

  2. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    gonna start downing pounds of both now
    *185th U.S. Air Force*
  3. New Member
    aLinux's Avatar
    Stats
    6'0"  201 lbs.
    Join Date
    Oct 2009
    Age
    43
    Posts
    108
    Rep Power
    550
    Level
    9
    Lv. Percent
    12.8%

    Molecular Weight 177.25 - Therapeutic dose of 0.25-1ul so you'd need about 10mg but no more than 25mg daily else you start ruin stem cells.
    400mcg * 60 capsules = 24mg .. so you'd need to take one bottle daily. I'd look for another supplement between 10-25mg NOT mcg.
    •   
       

  4. Senior Member
    The Engineer's Avatar
    Stats
    5'9"  160 lbs.
    Join Date
    Jun 2013
    Posts
    1,182
    Rep Power
    399816
    Level
    37
    Lv. Percent
    58.1%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by aLinux View Post
    Molecular Weight 177.25 - Therapeutic dose of 0.25-1ul so you'd need about 10mg but no more than 25mg daily else you start ruin stem cells.
    400mcg * 60 capsules = 24mg .. so you'd need to take one bottle daily. I'd look for another supplement between 10-25mg NOT mcg.
    Seems like our only sources then are pharma research companies.
  5. New Member
    aLinux's Avatar
    Stats
    6'0"  201 lbs.
    Join Date
    Oct 2009
    Age
    43
    Posts
    108
    Rep Power
    550
    Level
    9
    Lv. Percent
    12.8%

    This one here (30mg a capsule) should be good-to-go: http://www.swansonvitamins.com/jarro...mg-60-veg-caps I read somewhere else that we can use up to 75mg daily but I'd still
    stick to around 30-60mg if that's true. I think I'll try that brand - give it a shot as well. Anything that helps lower Mystoatin plus all the other benefits of sulforaphane
    is worth a try.
  6. New Member
    mmats's Avatar
    Join Date
    May 2012
    Posts
    44
    Rep Power
    2225
    Level
    6
    Lv. Percent
    65.14%

    This was a test tube study...
  7. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by mmats View Post
    This was a test tube study...
    just because it was in vitro doesnt mean it should be totally written off
    *185th U.S. Air Force*
  8. New Member
    Solar's Avatar
    Stats
    6'5"  204 lbs.
    Join Date
    Sep 2012
    Posts
    7
    Rep Power
    29
    Level
    2
    Lv. Percent
    62.17%

    There seems to be some evidence that there is some health gains, and the product is cheep enough it's worth a try. I think I will pick up a bottle and try a pill pre and post workout.
  9. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by The Engineer View Post
    From ergo-log:
    Cauliflower, broccoli & bodybuilders

    If we were to do some anecdotal testing of our own using Swanson's Sulforaphane (Swanson GreenFoods Formulas Sulforaphane from Broccoli - 100% Natural 400 mcg 60 Veg Caps - Swanson Health Products) what would be the necessary dose required to recreate the tests?
    these supps are not very good since they contain the sulforaphane in a form which cannot be absorbed well

    Its better to buy broccoli sprouts and eat them

    the tests were done in-vitro so extrapolation to human in vivo dose is too difficult to predict without information regarding bioavalabilty, disposition in tissues, half life etc
    Anabolicminds.com Featured Author
  10. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by aLinux View Post
    Molecular Weight 177.25 - Therapeutic dose of 0.25-1ul so you'd need about 10mg but no more than 25mg daily else you start ruin stem cells.
    .
    explain how you made that calculation

    how is a unit of volume a dosage to begin with
    Anabolicminds.com Featured Author
  11. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    I have researched this way more than any of you guys so trust me when i say the way to go is to buy this from the store and try to eat a package a day

    http://www.broccosprouts.com/
    Anabolicminds.com Featured Author
  12. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    where can you find those^
    *185th U.S. Air Force*
  13. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    i will look at hyvee
    *185th U.S. Air Force*
  14. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    you should be able to find them at most supermarkets. broccoli seed or sprout suppleemnts dont work because the sulforaphane is stuck in an unusuable form. live broccoli sprouts release the enzyme myrosinase which then frees up the sulforaphane
    Anabolicminds.com Featured Author
  15. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    they have to be pretty expensive no?
    *185th U.S. Air Force*
  16. New Member
    Markos4's Avatar
    Join Date
    Dec 2013
    Posts
    201
    Rep Power
    104713
    Level
    18
    Lv. Percent
    64.14%

    I bought myo x for $70 but i dont know if it worked for me.. maybe it was placebo, my joints definitely started hurting after two weeks of taking this as a side effect.
  17. New Member
    Markos4's Avatar
    Join Date
    Dec 2013
    Posts
    201
    Rep Power
    104713
    Level
    18
    Lv. Percent
    64.14%

    Quote Originally Posted by Patrick Arnold View Post
    I have researched this way more than any of you guys so trust me when i say the way to go is to buy this from the store and try to eat a package a day

    http://www.broccosprouts.com/
    Hey this seems pretty legit,i wonder how much are they for..
  18. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Markos4 View Post
    I bought myo x for $70 but i dont know if it worked for me.. maybe it was placebo, my joints definitely started hurting after two weeks of taking this as a side effect.
    placebo for sure, there is no supplement that will lower myostatin. they dont even have pharmaceutical drugs that will do that yet
    *185th U.S. Air Force*
  19. Senior Member
    Beau's Avatar
    Join Date
    Jan 2005
    Posts
    2,873
    Rep Power
    854638
    Level
    50
    Lv. Percent
    47.8%
    Achievements Activity ProPosting Pro

    Mountain Rose Herbs, a website I buy many bulk powders from, carries Broccoli sprouting Seeds.

    I bought them and am soaking them now, and they should start sprouting in a couple of days.

    More to follow.

    FWIW - my experience with Jarrow supplements has been very, very good, and I see them as a provider of high quality/cost effective products.
  20. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by cumminslifter View Post
    placebo for sure, there is no supplement that will lower myostatin. they dont even have pharmaceutical drugs that will do that yet
    thats not true, many drugs have been shown to do that (clen, AAS) as welll as creatine and just recently the active isomer of the beta blocker pindolol

    none of these are target specific for myostatin though
    Anabolicminds.com Featured Author
  21. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Beau View Post
    Mountain Rose Herbs, a website I buy many bulk powders from, carries Broccoli sprouting Seeds.

    I bought them and am soaking them now, and they should start sprouting in a couple of days.

    More to follow.

    FWIW - my experience with Jarrow supplements has been very, very good, and I see them as a provider of high quality/cost effective products.
    you need the johns hopkins seeds from Caudill Sprouting. They were engineered to be high in sulforaphane precursor
    Anabolicminds.com Featured Author
  22. New Member
    Markos4's Avatar
    Join Date
    Dec 2013
    Posts
    201
    Rep Power
    104713
    Level
    18
    Lv. Percent
    64.14%

    Quote Originally Posted by Patrick Arnold View Post

    thats not true, many drugs have been shown to do that (clen, AAS) as welll as creatine and just recently the active isomer of the beta blocker pindolol

    none of these are target specific for myostatin though
    Creatine decreases myostatin?? I don't believe it..
  23. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Markos4 View Post
    Creatine decreases myostatin?? I don't believe it..
    REsistance exercise decreases myostatin and resistance exercise combined with creatine reduces it even more. you need to take myostatin into perspective - many things which help promote muscle mass effect a variety of signalling molecules to some extent. Its different than dramatic pharmaceutical reduction or induction of one of those molecules though


    Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30. doi: 10.1016/j.mce.2009.12.019. Epub 2009 Dec 22.
    Effects of oral creatine and resistance training on serum myostatin and GASP-1.
    Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K.
    Source
    Department of Sport Science, Arak University, Arak, Iran.
    Abstract
    Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
    Anabolicminds.com Featured Author
  24. Elite Member
    Montego1's Avatar
    Stats
    6'1"  236 lbs.
    Join Date
    Apr 2010
    Posts
    8,584
    Rep Power
    7366198
    Level
    96
    Lv. Percent
    10.88%
    Achievements Activity ProActivity AuthorityActivity VeteranActivity RoyaltyPosting ProPosting Authority

    Glad to see your pretty face here again PA. How is the new new Clearshot coming along?

    ​" If you're looking for a work horse.......I'm no Clydesdale."
  25. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,637
    Rep Power
    1594941
    Level
    67
    Lv. Percent
    1.04%
    Achievements Activity ProActivity AuthorityPosting Pro

    Quote Originally Posted by Patrick Arnold View Post

    REsistance exercise decreases myostatin and resistance exercise combined with creatine reduces it even more. you need to take myostatin into perspective - many things which help promote muscle mass effect a variety of signalling molecules to some extent. Its different than dramatic pharmaceutical reduction or induction of one of those molecules though

    Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30. doi: 10.1016/j.mce.2009.12.019. Epub 2009 Dec 22.
    Effects of oral creatine and resistance training on serum myostatin and GASP-1.
    Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K.
    Source
    Department of Sport Science, Arak University, Arak, Iran.
    Abstract
    Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
    What about stat3 Inhibitors?
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  26. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Patrick Arnold View Post
    thats not true, many drugs have been shown to do that (clen, AAS) as welll as creatine and just recently the active isomer of the beta blocker pindolol

    none of these are target specific for myostatin though
    exactly my point, nothing that targets it specifically
    *185th U.S. Air Force*
  27. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by EBF Inc View Post
    What about stat3 Inhibitors?

    apparently they have that ability
    Anabolicminds.com Featured Author
  28. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by cumminslifter View Post
    exactly my point, nothing that targets it specifically
    most anabolic drugs effect a variety of systems so it makes me wonder if a drug that just targets myostatin would be so great. Unless it just really knocked it out
    Anabolicminds.com Featured Author
  29. New Member
    Vj63's Avatar
    Join Date
    Nov 2013
    Posts
    44
    Rep Power
    73905
    Level
    14
    Lv. Percent
    43.76%

    ...
    Last edited by Vj63; 12-14-2013 at 04:46 PM. Reason: missed quotation
  30. New Member
    Vj63's Avatar
    Join Date
    Nov 2013
    Posts
    44
    Rep Power
    73905
    Level
    14
    Lv. Percent
    43.76%

    Quote Originally Posted by Patrick Arnold View Post
    I have researched this way more than any of you guys so trust me when i say the way to go is to buy this from the store and try to eat a package a day
    I take offense to this this statement.
    I have spent at least 10 minutes, if not 15 scouring the research on this matter bro.
  31. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Vj63 View Post
    I take offense to this this statement.
    I have spent at least 10 minutes, if not 15 scouring the research on this matter bro.
    well then you must be second most well versed
    Anabolicminds.com Featured Author
  32. Advanced Member
    Rostam's Avatar
    Join Date
    Jul 2004
    Posts
    789
    Rep Power
    46882
    Level
    24
    Lv. Percent
    25.63%

    Some years ago there was a company that was selling standardized high sulforaphane broccoli seeds for sprouting. I used to buy these to grow my own broccoli sprouts but I can't find this company or their website anymore.
  33. Senior Member
    cumminslifter's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Feb 2013
    Age
    21
    Posts
    1,955
    Rep Power
    1689669
    Level
    55
    Lv. Percent
    72.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Rostam View Post
    Some years ago there was a company that was selling standardized high sulforaphane broccoli seeds for sprouting. I used to buy these bad grow my own broccoli sprouts but I can't find this company or their website anymore.
    did you notice anything from taking them?
    *185th U.S. Air Force*
  34. Senior Member
    Beau's Avatar
    Join Date
    Jan 2005
    Posts
    2,873
    Rep Power
    854638
    Level
    50
    Lv. Percent
    47.8%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Rostam View Post
    Some years ago there was a company that was selling standardized high sulforaphane broccoli seeds for sprouting. I used to buy these bad grow my own broccoli sprouts but I can't find this company or their website anymore.
    Do tell, do tell
  35. Advanced Member
    Rostam's Avatar
    Join Date
    Jul 2004
    Posts
    789
    Rep Power
    46882
    Level
    24
    Lv. Percent
    25.63%

    at that time I was eating that for its health benefit. i didn't even know it could have any effect on myostatin. i may need try it again. but first i have to find proper seeds. i red not all seeds will grow sprouts with same sulfuraphane content.
  36. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554325
    Level
    50
    Lv. Percent
    40.27%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Rostam View Post
    Some years ago there was a company that was selling standardized high sulforaphane broccoli seeds for sprouting. I used to buy these to grow my own broccoli sprouts but I can't find this company or their website anymore.
    caudill
    Anabolicminds.com Featured Author
  

  
 

Similar Forum Threads

  1. Myostatin inhibition
    By jimbuick in forum Supplements
    Replies: 9
    Last Post: 12-08-2012, 09:36 PM
  2. Myostatin Inhibition - again!
    By Whacked in forum Supplements
    Replies: 24
    Last Post: 11-02-2009, 08:56 AM
  3. Sulforaphane Inhibits Lung Metastasis
    By yeahright in forum Nutrition / Health
    Replies: 0
    Last Post: 06-08-2006, 01:48 AM
  4. Myostatin Binders/Blockers---Next Scam!
    By Blindfaith in forum Supplements
    Replies: 3
    Last Post: 12-05-2002, 03:19 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in