COMT inhibition and N-Coumaroyldopamine

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    COMT inhibition and N-Coumaroyldopamine


    Are there any effective OTC COMT inhibitors that could allow N-Coumaroyldopamine to stay active longer to exert it's benefits? I know EGCG and quercetin both inhibit it to some degree but aren't overly potent at doing so.

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    The kinetics of NCD aren't as simple as initially thought. While it is indeed a substrate for COMT, the testing of myself and others (i.e. BK) with pure NCD (tough to find) shows that its effects persist much longer than predicted.

    EGCG and quercetin won't appreciably affect COMT though, to your point
    http://pescience.com/
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    The above is my own opinion and does not reflect the opinion of PES
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    Interesting. At the very least its good to know that it's not just a expensive waste. I guess we'll just have to wait for more studies. Thanks Coop.
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    Rhodiola rosea?
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    Quote Originally Posted by JudoJosh View Post
    Rhodiola rosea?
    I use that **** for my runs
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    I've seen rhodiola mentioned as a COMT inhibitor a few times, but never any concrete evidence that shows it actually works as one. Specifically I've seen different sites state it inhibits COMT up to 60% but they don't link to anything to back that up.
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    I hope this doesnt break any board rules but when I read this thread, I wanted to learn more about COMT.

    I stumbled across this informative thread. It discussed Warrior vs Worrier. Man, that is so me any more. Need to get to the bottom of this. Coop, can I hire you as my Doc and you fix me?

    My anxiety is off the charts anymore as are my seemingly LOW dopamine levels.

    Figured out why I have low Dopamine - High COMT enzyme activity - Social Anxiety Forum

    Quote Originally Posted by BlackWinging View Post
    Are there any effective OTC COMT inhibitors that could allow N-Coumaroyldopamine to stay active longer to exert it's benefits? I know EGCG and quercetin both inhibit it to some degree but aren't overly potent at doing so.
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    Quote Originally Posted by Whacked View Post
    I hope this doesnt break any board rules but when I read this thread, I wanted to learn more about COMT.

    I stumbled across this informative thread. It discussed Warrior vs Worrier. Man, that is so me any more. Need to get to the bottom of this. Coop, can I hire you as my Doc and you fix me?

    My anxiety is off the charts anymore as are my seemingly LOW dopamine levels.

    Figured out why I have low Dopamine - High COMT enzyme activity - Social Anxiety Forum

    Very interesting and a lot of what is said seems to apply to me. Definitely subbed for more info
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    Quote Originally Posted by BlackWinging View Post
    I've seen rhodiola mentioned as a COMT inhibitor a few times, but never any concrete evidence that shows it actually works as one. Specifically I've seen different sites state it inhibits COMT up to 60% but they don't link to anything to back that up.
    This paper www.ncbi.nlm.nih.gov/m/pubmed/11410073/ mentions it may inhibit COMT and uses this as a reference

    Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol 1987;40:85-87

    Which I cant seem to find but it appears that they gave r. Rosea to rats and observed changes in monoamine levels and hypothesized the changes were the result of r. Rosea inhibiting COMT. Hardly says much though since r. Rosea is a MAO inhibitor (both A and B) http://www.ncbi.nlm.nih.gov/pubmed/19168123 which can explain the changes they observed.
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    Mentione the wrong gene expression. My fault. Mis read.
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    Quote Originally Posted by EBF Inc View Post
    Comt and pomc are related directly to hunger and fat burning. Just saying
    Whats all this mean in laymen terms? If you have high COMT then you are hungrier and burn more fat?

    Would NCD increase COMT ? All this stuff kind of loses me.
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    Quote Originally Posted by EBF Inc View Post
    Comt and pomc are related directly to hunger and fat burning. Just saying
    Whoops sorry thought we were talking about the CART system. My fault
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    Quote Originally Posted by 3clipseGT View Post

    Whats all this mean in laymen terms? If you have high COMT then you are hungrier and burn more fat?

    Would NCD increase COMT ? All this stuff kind of loses me.
    I was thinking we were talking about the effects of CART disregard statement
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    Quote Originally Posted by JudoJosh View Post
    This paper www.ncbi.nlm.nih.gov/m/pubmed/11410073/ mentions it may inhibit COMT and uses this as a reference

    Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol 1987;40:85-87

    Which I cant seem to find but it appears that they gave r. Rosea to rats and observed changes in monoamine levels and hypothesized the changes were the result of r. Rosea inhibiting COMT. Hardly says much though since r. Rosea is a MAO inhibitor (both A and B) http://www.ncbi.nlm.nih.gov/pubmed/19168123 which can explain the changes they observed.
    Yeah I saw this being discussed on another forum before. The discussion basically went "rhodiola isn't a COMT inhibitor, the study was done before the one finding it was an MAO inhibitor which would explain the increase in serotonin". Still looks like a great herb, and I'm planning on getting some for when I do a caffeine tolerance break.

    Quote Originally Posted by EBF Inc View Post
    Whoops sorry thought we were talking about the CART system. My fault
    I've never heard of the CART system before, care to do a basic overview?
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    Quote Originally Posted by 3clipseGT View Post

    Whats all this mean in laymen terms? If you have high COMT then you are hungrier and burn more fat?

    Would NCD increase COMT ? All this stuff kind of loses me.
    Here's the info you want on comt sorry for confusion,again.

    http://www.genecards.org/cgi-bin/carddisp.pl?gene=COMT

    http://m.pharmrev.aspetjournals.org/.../51/4/593.full
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    Quote Originally Posted by BlackWinging View Post



    I've never heard of the CART system before, care to do a basic overview?
    Better then explaining because there are multiple regulators of this gene like leptin npy agouti and pomc

    http://www.genecards.org/cgi-bin/car...pl?gene=CARTPT

    http://en.m.wikipedia.org/wiki/Cocai...ted_transcript

    http://www.medscape.com/viewarticle/406030

    http://m.jpet.aspetjournals.org/content/320/2/499.long

    Now pomc
    http://www.genecards.org/cgi-bin/carddisp.pl?gene=POMC

    http://www.nutritionandmetabolism.co...-7075-4-18.pdf


    Relationship between pomc leptin and cart


    Maybe coops corner on this one. Can be very in depth

    http://www.ncbi.nlm.nih.gov/m/pubmed/9883730/

    http://www.ncbi.nlm.nih.gov/m/pubmed/12421341/

    https://www.utoledo.edu/med/depts/ph...Expression.pdf

    Below shows a chart of relationship

    http://mutagenetix.utsouthwestern.ed...rec.cfm?pk=109
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    Looks like I have my reading for day. Thanks, always happy to learn.
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    Quote Originally Posted by BlackWinging View Post

    Looks like I have my reading for day. Thanks, always happy to learn.
    There is a lot of overlapping information. It's basically leptin activates these systems to increase fat burning an reduce hunger

    Mch3/4 in the pomc system are more related to feeding and burning as well
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