All aboard the Betaine train.
- 11-19-2013, 10:20 PM
- 11-19-2013, 11:26 PM
- 11-20-2013, 12:12 AM
phaggy opinions+certainty=douchebag status
11-20-2013, 12:14 AM
11-20-2013, 12:17 AM
11-20-2013, 08:49 AM
11-20-2013, 09:42 AM
11-20-2013, 10:08 AM
11-20-2013, 10:12 AM
11-20-2013, 10:58 AM
11-20-2013, 11:11 AM
I read another person on here months ago who claimed of smelling like maple syrup while on Slintensity. This isn't the first case.
11-20-2013, 12:42 PM
11-20-2013, 12:48 PM
I like the smell of maple syrup....
but no - this is not indicative nor an effect of TMG usage, in any way/shape/form
don't know anything about slintensity personally, but my logical hypothesis would be it perhaps contains more fen than what they list, or you are individually susceptible to that side-effect from that particular compound
11-20-2013, 12:52 PM
11-20-2013, 12:57 PM
11-20-2013, 05:50 PM
phaggy opinions+certainty=douchebag status
11-20-2013, 06:51 PM
11-20-2013, 07:48 PM
11-20-2013, 09:05 PM
I know a guy at the gym who died from Betaine poisoning. He took 6.5 grams..0.5 grams above the NOW recommendation and he exploded. RIP Betaine Bob, you knew how to live life except that you exceeded the imaginary bell curve into toxicity/spontaneous combustion. You should have headed the warnings from strangers on the internet with no research background in this compound...but no, you had to do things your way.
11-20-2013, 09:50 PM
11-21-2013, 02:41 AM
Enlighten me o Betaine god.
The toxiological bell curve was a joke, but performance studues show 2.5g to be the mark in which performance enhances.
But since you clearly know more than I do on the subject; can you please explain to us lesser folk what the advantages of dosing higher are?
Edit: nothing wrong with experimenting with higher doses, but considering you insulted me I will fight back
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11-21-2013, 08:54 AM
What is NOW reasoning for recommending up to 6 grams a day ? There has to be a reason and I doubt they would recommend unsafe dosages
11-21-2013, 08:58 AM
Quick google search I guess this the reason for 6 grams ? More for liver health I guess than performance ??
The Foundation has identified several cases in which people who were suffering from coronary artery disease had lethal levels of homocysteine despite taking the recommended dose (and higher) of vitamin supplements.
One case involved a 60-year-old man who previously had bypass surgery, but who was again suffering angina pain with significant restenosis (reclogging of the coronary arteries) verified by angiography. This man knew about the dangers of homocysteine and had been taking more than 15,000 mcg a day of folic acid, along with other homocysteine-lowering vitamins. Because of the angina pain and restenosis, the Foundation recommended a homocysteine blood test. The results came back showing that this man had a shockingly high homocysteine reading of 18 in his blood. (Homocysteine levels over 15 have been shown to be extremely dangerous.) The Foundation immediately suggested this man take 6 grams a day of TMG (trimethylglycine), and within one month, his homocysteine level dropped to 4. This case was a wake-up call that one or more homocysteine-lowering factors are not always the solution to keeping homocysteine levels in the safest range (below 7). It was also a confirmation of our position that people who want to lower homocysteine must take in account all of the factors involved.
Another case involved a healthy person who took everyday a 500-mg TMG supplement, 4000 mcg of folic acid, and high doses of many other vitamins. A homocysteine blood test revealed a reading of 11.3, which is far above the safe range of under 7. Six grams of TMG and 500 mg of vitamin B6 were added to his daily program, and the homocysteine level dropped to under 6 within 60 days.
The most recent survey (Cardiologia, 1999, Apr, 44:341-45) shows that the average American's homocysteine level is 10, so the fact that 90% of Foundation members are below 10 is a testament to the effectiveness of dietary supplements in suppressing dangerously high homocysteine levels (Annals of Epidemiology, May 1997, 7:285-93).
The problem is that certain people are not being protected against the damaging effects of homocysteine, and the only way of finding out is to have a blood test. When homocysteine is too high, the addition of extra amounts of vitamin B6 and/or TMG (trimethylglycine) has reduced levels to the safest range in every case we have worked with. The Foundation has found that the addition of extra folic acid produces only a moderate reduction in elevated homocysteine levels. Folic acid is a critical component of a homocysteine-lowering program, but there is a limit to how much homocysteine can be reduced by folate and vitamin B12. Cardiologists are increasingly recommending folic-acid supplements to their coronary artery disease patients, but the results from the Foundation's laboratory indicate that it takes more than folic acid to reduce serum homocysteine to a level where it ceases to be a risk factor for causing a heart attack. - See more at: http://www.lifeextensionvitamins.com....3Tfsd4CD.dpuf
11-21-2013, 09:21 AM
I'm guessing there are studies out there that use 3-6 grams to evaluate it's effect on high levels of homocysteine, and seeing that 6 grams was more effective use that as a recommendation. I doubt TMG would cause anything bad at that dose, other than the chance of fishy body odor being increased greatly.
I did have a question about choline and it being metabolized into TMG. If I take 3 grams of choline citrate, about how much of it would be metabolized into TMG? And would supplementation with TMG reduce how much choline is metabolized into TMG?
11-21-2013, 10:25 AM
Just stick with 2.5 until there's more research. That's the best move. If it's a saturation thing then it'll eventually get to capacity, just depends on how long.
11-21-2013, 11:33 AM
As for choline to betaine....I believe if you are supplementing with choline and TMG, then very little would be used to synthesize TMG. TMG has a choline sparing effect, and choline will only be used for TMG synthesis when either (or both) betaine and folate consumption is low.
11-21-2013, 11:43 AM
11-21-2013, 11:46 AM
11-21-2013, 11:49 AM
11-21-2013, 11:59 AM
Oh, I didn't think it's main MoA was the homocysteine reduction, just that that was one of the most studied aspects. The GH/IGF-1 aspect is what I'm most interested in betaine for, as I already get the increased hydration from taurine/creatine.
That's good to hear, I saw that choline increased serum levels of TMG quite high by itself, so I'm glad TMG can spare the choline I take.
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