TTA (tetradecylthioacetic acid) Safety
- 07-06-2013, 03:25 AM
- 07-06-2013, 09:28 PM
This study describes the clinical, hematological, and biochemical safety of tetradecylthioacetic acid (TTA). A total of 18 healthy volunteers were included. Subjects were randomly assigned into 3 groups according to the daily given dose of TTA: group 1 (200 mg), group 2 (600 mg), and group 3 (1000 mg). TTA was given as a single oral dose for 7 consecutive days. Safety was evaluated by following the adverse events, vital signs, and hematological and biochemical parameters in blood and urine samples. Efficacy was estimated through its effects on plasma lipids profile. Few adverse events of mild severity were reported. No clinically significant changes were observed in the hematological or clinical chemical parameters in blood/urine. TTA did not induce significant changes in the blood lipids or free fatty acids, but it did result in an increase in plasma concentration of Delta9 desaturated TTA (TTA: 1n-8). Serum concentration pattern of TTA at day 1 showed a 1.5-hour lag time followed by a rapid absorption and a slower elimination phase. The median peak values were 2.9 mg/L (range, 1.1 to 5.4 mg/L), 11.5 mg/L (range, 4 to 35 mg/L), and 11 mg/L (range, 5 to 25 mg/L), in groups 1, 2, and 3, respectively (P = 0.006). The time to peak levels were 3.5 hours (range, 2.5 to 6.5 hours), 2.5 hours (range, 2.5 to 4.5 hours), and 4.5 hours (range, 2.5 to 12 hours), respectively (P = 0.2). TTA is safe and well tolerated.
- 07-07-2013, 03:09 AM
Dr.d was very much against TTA, said it damages heart muscle
07-07-2013, 05:25 AM
The discussion speculating against it's use was due to it building up in tissue.
The study that Aaron posted was only 7 days long so the safety extrapolations from it would be limited.
I have read mixed research so I am subbing for discussion.
07-07-2013, 05:27 AM
07-07-2013, 05:30 AM
07-07-2013, 09:24 AM
Please send any unwanted TTA to me
As for safety, there was some cardiac concerns I believe. Lemme see if I can pull up the study
07-07-2013, 09:33 AM
thanks for all the input.
@ josh - i would ...but i live in europe
07-07-2013, 09:53 AM
07-07-2013, 09:57 AM
07-07-2013, 10:13 AM
07-07-2013, 10:58 PM
The above is my own opinion and does not reflect the opinion of PES
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