Hey guys, I was looking for some articles for my genetics project and stumbled across this. I thought it was pretty interesting from what I skimmed through. I know it's a study in rats, and that humans are not rats, but its intriguing nonetheless. What do you guys think?
Heres the link to the study:
Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in the Hypothalamus and Activating The Sympathetic Nervous System
Some of the major points I got out of the study were:
1. "leucine deprivation increases lipolysis in WAT and UCP1 expression in BAT"
2. "Based on these controls, leucine deprivation reduced fat mass (∼50%) and body weight (∼14%)"
3. "administration of leucine decreases levels of activated hormone sensitive lipase (HSL) in WAT and UCP1 (uncoupling protein 1) expression in BAT and significantly attenuates fat loss in leucine-deprived mice."
4. "we show that intracerebroventricular administration of leucine significantly attenuates abdominal fat loss and blocks activation of hormone sensitive lipase in WAT and induction of UCP1 in BAT in leucine-deprived mice. Furthermore, we provide evidence that leucine deprivation stimulates fat loss by increasing expression of corticotrophin-releasing hormone in the hypothalamus via activation of stimulatory G protein/cAMP/protein kinase A/cAMP response element-binding protein pathway."