Ashwagandha, more than an adaptogen
- 08-31-2012, 08:39 AM
Ashwagandha, more than an adaptogen
Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males.
To investigate the impact of Withania somnifera roots on semen profile, oxidative biomarkers, and reproductive hormone levels of infertile men.
Departments of Biochemistry and Urology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.
Seventy-five normal healthy fertile men (control subjects) and 75 men undergoing infertility screening.
High-performance liquid chromatography assay procedure for quantization of vitamin A and E in seminal plasma. Biochemical parameters in seminal plasma were estimated by standard spectrophotometric procedures. Estimation of T, LH, FSH, and PRL in blood serum by RIA methods.
MAIN OUTCOME MEASURES(S):
Before and after the treatment, seminal plasma biochemical parameters, antioxidant vitamins, and serum T, LH, FSH, and PRL levels were measured.
Withania somnifera inhibited lipid peroxidation and protein carbonyl content and improved sperm count and motility. Treatment of infertile men recovered the seminal plasma levels of antioxidant enzymes and vitamins A, C, and E and corrected fructose. Moreover, treatment also significantly increased serum T and LH and reduced the levels of FSH and PRL.
The treatment with W. somnifera effectively reduced oxidative stress, as assessed by decreased levels of various oxidants and improved level of diverse antioxidants. Moreover, the levels of T, LH, FSH and PRL, good indicators of semen quality, were also reversed in infertile subjects after treatment with the herbal preparation. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
- 08-31-2012, 11:57 AM
Not sure what dosage they used. But I've been taking 450mg of sensoril extract and it along with zinc has had a bigger impact on endurance and libido than any $30 test booster I have used. Was a pleasant surprise.
- 08-31-2012, 12:03 PM
08-31-2012, 12:26 PM
Careful not to go too high
The above is 3000mg. I know people who have taken 1000mg but it becomes quite sedating that high. Personally I take 450mgEffect of Withania somnifera root extract on the sexual behaviour of male rats.
To determine the effect of a methanolic extract of Withania somnifera (L.) Dunal roots on sexual competence of male rats.
Male rats were orally administered 3000 mg.kg-1.day-1 of root extract for 7 days. Their sexual behaviour was evaluated 7 days prior to treatment, day 3 and 7 of treatment, and day 7, 14 and 30 post-treatment by pairing each male with a receptive female.
The root extract induced a marked impairment in libido, sexual performance, sexual vigour, and penile erectile dysfunction. These effects were partly reversible on cessation of treatment. These antimasculine effects are not due to changes in testosterone levels or toxicity but may be attributed to hyperprolactinemic, GABAergic, serotonergic or sedative activities of the extract.
Use of W. somnifera roots may be detrimental to male sexual competence.
08-31-2012, 12:29 PM
08-31-2012, 01:11 PM
I thought as much but wasn't sure. I'll have to see what potency Sensoril is. I'm enjoying taking it very much. Most supplements have little effect on me so nice to find one that I can actually feel a positive difference on.Originally Posted by mr.cooper69
Been sleeping pretty good on it. I don't find it sedating at all. I take one when I get up and one before bed.
08-31-2012, 01:15 PM
Depending on the formula used to extrapolate rodent dosages to humans its probably closer to 40 grams in an 80kg man. A pretty insane dosage by any means.Originally Posted by mr.cooper69
Found this. May be old news though
08-31-2012, 04:56 PM
08-31-2012, 06:24 PM
That method is how I usually convert dosages. Has its flaws thoughOriginally Posted by JudoJosh
09-27-2012, 11:30 AM
more recent info
Found they have a new website up with more up to date info at sensoril.com
09-27-2012, 12:35 PM
I find the regular NOW version to be pretty potent. 1 cap plus 3 caps of magnesium threonate and I am one chill dude. I'll try the sensorial version at some point.
02-02-2014, 06:42 PM
What about the KSM-66 derivative standardized to 5%?
02-03-2014, 12:24 AM
02-03-2014, 08:33 AM
02-03-2014, 08:58 AM
02-03-2014, 09:28 AM
Firstly, I'm certain I read that it might cause GI issues. Hard to tell, as I'd been eating chili twice a day. I seem to get more of a coffee-like effect. As for the rest of the effects, it's mild increased T positives all around that might also be caused by other stuff I've bee playing with for the past 10 days so I can't say for certain, but I think I'd attribute, at the very least, the increased capacity for volume training to the ashwagandha.
Oh. I'm also becoming convinced that dropping digestive enzymes with it helps.
02-03-2014, 01:56 PM
"Train like a beast, think like a human"-RTS
02-03-2014, 06:01 PM
02-03-2014, 06:13 PM
02-03-2014, 08:20 PM
02-07-2014, 05:54 PM
One product that I would like to try is Biotivia's Bioforge and this is an ingredient. It seems to get very good reviews by almost all who take it.
02-20-2014, 06:03 AM
Does anyone have experience with many forms of ashwagandha, especially the NOW foods 2.5% and sensoril?
I just went through a bottle of the NOW brand. Combined with relora, it relaxed and sedated me and was a perfect night cap, even eliminating my need for other stronger sleep aides (combined with melatonin).
I bought the Smart Powders brand which claimed to be 5%, but it doesn't have the same sedating/relaxing/anti-anxiety effect as the NOW foods at 300 or 600mg (even though it's supposed to be twice as strong). I have heard about sensoril (and I just read about KSM-66 in this thread), and I am curious if anyone has direct experience and can compare the effects to the NOW brand. I am only using it at night to relax me (combined with relora), so I am only after the sedating/relaxing/anti-anxiety effects (I assumed that the effects would be comparable with all extracts, but my experience with the Smart Powders brand left me thinking that different extracts will have vastly different effects...or maybe their extract just sucks?). Thanks in advance!
As a side note, I have been running relora/ashwagandha for about 3.5 months now. How long can I run this combo before I should take a break, and how long should that break be?
02-20-2014, 06:22 PM
I don't have all of your answers but Smart Powders bulks being of poor quality seems semi common. Haven't tried myself, but this isn't the first time I've heard question of their bulk products vs other brands.
"Train like a beast, think like a human"-RTS
02-20-2014, 07:21 PM
02-24-2014, 08:20 AM
NOW brand at 2.5% has been far and away the best ashwagandha brand I have tried and I have used numerous brands. For me, it is sedating in an a anxiolytic way, but also mentally stimulating. It relaxes nervous energy, but also gets the mind going and opened up. I can't take it past 3-4pm because I will be up all night thinking about things I want to do.
02-24-2014, 08:42 AM
Thanks so much for your input! The fact that you have tried a lot of brands and seem to have been taking ashwagandha for a long time means you are exactly the kinda guy I was hoping to hear from .
02-24-2014, 08:57 AM
I really couldn't tell you all the brands because I have gone through 6-7 over the years and yes I have tried the Sensoril, from Jarrow I believe it was. It is sedating and relaxing, which is what I did not want because I want the edge off, but to be mentally sharp. It was a bit much since I am very sensitive to this. For your needs, it may be what you are looking for.
I am not familiar with the KSW-66 until you just mentioned it.
02-24-2014, 09:01 AM
So you found the Sensoril to be a much stronger sedating effect than the NOW foods version? Any other differences you noticed? BTW where are you at in CO? I was born in Boulder.
02-24-2014, 09:03 AM
****Correction. It is KSM-66, not KSW-66. My bad!***
02-24-2014, 09:17 AM
About Sensoril- yes, definitely more sedating. More dulling is the feeling and that would be great in high stress times, but not for me. I like to be very mentally aware and physically relaxed in high stress times.
02-24-2014, 09:20 AM
02-24-2014, 09:29 AM
I just ordered the Nutri Gold brand of KSM-66 and will report back on the differences or similarities from the NOW brand.
02-24-2014, 09:42 AM
02-25-2014, 01:02 PM
02-25-2014, 01:07 PM
Everybody's chenistry is different because Ashwagandha and Bacopa give me great energy, but calm my anxiousness. In fact, I take it before a workout because I can really concentrate and focus on my lifts better.
All reports I have read say that the KSM-66 gives energy, so we'll see how it goes.
02-25-2014, 03:47 PM
02-25-2014, 06:27 PM
You guys are getting me really interested in bacopa as well. I might have to give that a try at some point. It would probably be overkill with ashwagandha and relora, though, so I might have to try those three in different combinations. I have been taking only relora/melatonin at night recently (got a bad batch of ashwagandha that seems to wake me up instead of putting me to sleep, and will need a break in a few days anyway, so just stopped taking it), and that is still nice and sedating, but not as nice as relora/ashwagandha/melatonin. Maybe bacopa will fit into there somewhere as well. I will look for some bacopa supplements to try.
02-28-2014, 06:21 AM
Even though it's only been a few days, I'm really enjoying ashwagandha stacked with bacopa. They seem to compliment each other nicely.
02-28-2014, 08:27 AM
Good for you, it really is an amazing synergy with the two. Glad it is working out.
02-28-2014, 08:30 AM
I'll finish off the bottle and stick with the brand that I have been enjoying.
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