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ManimalPatB NurseGray TrainerTone cobri66 criticalbench sparks2012
Thank you for the opportunity to try this amazing looking supplement!
I will be logging this as a Post Workout, though it can fit well into any category.
Pre; Intra; and Post.
I will be logging this as a Post Workout, though it can fit well into any category.
Pre; Intra; and Post.
What I love about it, is the inclusion of BCAAs and in a 4:1:1 instead of the 2:1:1 ratios and the quantities of the other ingredients!.
This is one of my reasons:
"Leucine is one of the three Branched Chain Amino Acids and sometimes referred to as the 'main' amino acid due to the most popular benefit of BCAAs (muscle building) being mostly due to leucine. Leucine is an activator of the protein known as mTOR, which then induces muscle protein synthesis via S6K; the other two BCAAs may also activate mTOR, but are much weaker than leucine in doing so (and as such, 5g of leucine will be more effective than 5g mixed BCAAs). The leucine metabolite, HMB, is also weaker than leucine at inducing muscle protein synthesis despite being more effective at preserving lean mass from breakdown.
Leucine is a tad different from the other two BCAAs Isoleucine and Valine as leucine seems to have a fair bit of testing on the amino acid in isolation rather than in a BCAA mixture, whereas the other two BCAAs are not as well studied.
The studies assessing leucine mostly look at muscle protein synthesis when additional leucine is added to the diet or to a test meal, and it appears that leucine is able to reliably increase muscle protein synthesis after test meals. Whether this results in more lean mass over a period of time is somewhat less reliable though, and leucine appears to be more effective at promoting gains in muscle in people with lower dietary protein intake and in the elderly (who tend to have impaired muscle protein synthesis in response to the diet).
The interactions of leucine on glucose are not clear, to be honest. Leucine possesses both blood sugar reducing properties (can release insulin from the pancreas, can directly stimulate glucose uptake into a cell without insulin) but also the opposite (via stimulating S6K, it can inhibit insulin-stimulated glucose uptake). In a cell culture, leucine stimulates glucose uptake for up to 45 minutes and then hinders itself while in living systems acute doses of leucine do not appear to do anything remarkable (some limited evidence that leucine can be rehabilitative in diabetes, but this is preliminary). Isoleucine is a more potent hypoglycemic agent, but to less inhibition of its own actions."
Source
https://examine.com/supplements/Leucine/
The other ingredients piqued my interested, so I did a little research on them.
Beta Alanine
"Beta-alanine is a modified version of the amino acid alanine.
Beta-alanine has been shown to enhance muscular endurance. Many people report being able to perform one or two additional reps in the gym when training in sets of 8–15 repetitions. Beta-alanine supplementation can also improve moderate- to high-intensity cardiovascular exercise performance, like rowing or sprinting.
When beta-alanine is ingested, it turns into the molecule carnosine, which acts as an acid buffer in the body. Carnosine is stored in cells and released in response to drops in pH. Increased stores of carnosine can protect against diet-induced drops in pH (which might occur from ketone production in ketosis, for example), as well as offer protection from exercise-induced lactic acid production.
Large doses of beta-alanine may cause a tingling feeling called paresthesia. It is a harmless side effect." Which I kind of like.
Source
https://examine.com/supplements/Beta-Alanine/
Betain (Trymethylglycine)
"Betaine (also known as TMG) is an ‘osmolyte’, a molecule that regulates water balance in cells. Betaine can directly methylate homocysteine, which is cardioprotective. It also indirectly affects folate and SAMe metabolism to support whole body methylation." So much more at the link.
Source
https://examine.com/supplements/Trimethylglycine/
L-Carnitine, L-Tartrate
"L-Carnitine and the related compound Acetyl-L-Carnitine (ALCAR) are compounds able to alleviate the effects of aging and disease on mitochondria, while increasing the mitochondria’s potential to burn fat.
ALCAR is often used as a brain booster, due to its ability to increase alertness and mitochondrial capacity while providing support for the neurons.
ALCAR has been shown to be very effective at alleviating the side effects of aging, like neurological decline and chronic fatigue. ALCAR supplementation is also a very safe method of improving insulin sensitivity and blood vessel health, particularly for people with delicate or weakened cardiac health. ALCAR can also protect neurons and repair certain damage, such as that caused by diabetes and diabetic neuropathy.
Theoretically, ALCAR supplementation for fat burning should work well, but studies on ALCAR in isolation do not show very good results. Fat loss is typically attributed to the increased activity done by people, from the increased energy they have from ALCAR supplementation."
An amazing Amino with so much potential in this matrix, I'm very excited at it's inclusion.
Source
https://examine.com/supplements/L-Carnitine/
Creatine HCL, Magnesium Creatine HCL/B]
We all know what Creatine does, and it increases power output, etc.
L-Glutamine
"Glutamine is a very effective intestinal and immune system health compound, as these cells use glutamine as the preferred fuel source rather than glucose.
It is generally touted as a Muscle Builder, but has not been proven to enhance muscle building in healthy individuals; only those suffering from physical trauma such as burns or muscular wounds (knife wounds) or in disease states in which muscle wasting occurs, such as AIDS. In these individuals, however, glutamine is effective at building muscle and alleviating a decrease in muscle mass typical of the ailment."
Source
https://examine.com/supplements/Glutamine/
L-Alanine
"L-alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM."
Oh, heck yeah!
Source
https://pubchem.ncbi.nlm.nih.gov/compound/L-alanine#section=Top
Also, I may be putting some notes about this supplement in my 6-8 week cut log as well.
