First of all, I would like to thank IBE for offering me the unique opportunity to log REVERSE
. My interest in Resveratrol began a few years ago. Since then, I have tried to read as much as I could on this unique and versatile compound. The more I read about it, the more impressed I was. The only drawback resveratrol possesses is poor oral bioavailability. The (preferably simultaneous) consumption of Bioperine/Piperine, Grapeseed Extract, Quercetin, Naringin/Dihydroxybergamottin has been shown to address this challenge to an extent. Given this background, it was obvious that Reverse
, with its advanced (triacetylated) form of resveratrol, would attract my interest. Needless to say, resveratrol has become one of my favourite compounds. One other one is Rhodiola
Rosea. Both beautifully demonstrate how natural compounds can single-handedly employ a variety of pathways to produce deep pharmacological benefits in the users. Besides the advanced form of resveratrol in REVERSE, the blend was given a synergistic boost by Shilajit and the next-generation form of vitamin B12, Glutathionylcobalamin.
I will use REVERSE at 3 capsules per day in three divided doses (during the first 10 days) to elevate cellular concentrations of the compounds, especially resveratrol, and 2 capsules per day in two divided doses (for the remaining 15 days).
So, this log will run for 25 days. This dosing scheme is my choice. Resveratrol dosage varies, depending on desired benefit. Some recommend between 20mg and 100mg daily for anti-aging purposes. To obtain some of the other benefits of resveratrol, higher dosages are recommended. Given the advanced nature of the resveratrol form in REVERSE, one capsule per day should be enough for long-term use.
: The first dose is first thing in the morning. The second will be early afternoon, and the last will be pre-bed. All on an empty stomach.
My primary interest in using REVERSE is to help elevate and sustain general well-being, enjoy its potent anti-aging effects via profound neutralization of the adverse effects of oxidative stress.
Considering that this log will not be a long-term use of REVERSE, resveratrol's anti-aging effects, in the classical sense of a calorie-restriction mimetic, that is, providing favourable changes in gene expression similar to those obtained from calorie restriction, will not be directly measurable during the span of this log for obvious reasons. However, indirect manifestations can be isolated. Some of these include, in a nut-shell: "antibiotic, anti-tumor, anti-diabetic, anti-ulcer, cardioprotective, anti-inflammatory, and anti-brain aging" effects. See
Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.
More specifically, resveratrol is known to produce effects such as boosting endothelial function by strengthening of the structural and cellular integrity of arteries and blood vessels via optimization of nitric-oxide synthesis, elimination of fat-clogged structures within blood vessels via reversal of cholesterol-induced reduction in nitric-oxide action, inhibition of oxidation of low-density
lipoprotein (LDL), and inhibition of the so-called platelet aggregation (blood clots) that can pose serious health problems; boosting of mitochondrial action and optimization of cardiovascular function via optimized blood-lipid profiles and enhanced
vasodilation; improved insulin sensitivity; protection of the brain from oxidative stress, leading to improved cognitive function; enhancement of immune function and protection of DNA structures; improvement of gastro-intestinal function by inhibiting the growth of stomach-ulcer causing bacteria; profound antioxidant activity via, amongst others, preservation of glutathione
, and neutralization of dangerous hydroxyl radicals; functioning as an anti-aromatase and anti-stress compound; and so on.
To measure the impact of REVERSE, I will focus on its impact on my general well-being, any noticeable improvements in strength and endurance
, vasodilation, cognitive function, libido, and body composition. I will try to update this log two to three times per week.
Now, welcome to my sponsored REVERSE log!