Sustained Release
Passive diffusion through the layers of the dermis creates a time-release effect that allows for sustained blood-levels of the active ingredients, and convenient once-daily dosing.
Increased bioavailability
Increased bioavailability through avoidance of the first-pass effect of hepatic metabolism can be a clear benefit of topical administration – particularly in the cases of active, non-17a-methylated hormones.
Activity Enhancers
The intercellular lipids of the stratum corneum are regarded as the major barrier to the permeation of lipophilic compounds. Salvo contains potent ingredients which modulate this lipid matrix & affect the non-polar permeation-enhancement route. These ingredients include thiazone, which is 3-12x more potent than azone as a permeation-enhancer for lipophilic molecules, and nerolidol, a lipophilic terpene which has been shown to be highly effective at facilitating the delivery of lipophilic molecules. It also includes oleic acid and stearyl methacrylate, fatty-acid derivatives which insert themselves between the hydrocarbon tails of intercellular stratum corneum lipids, and which thus disrupt lipid packing, increase fluidity, and promote diffusion through the external layer of the stratum corneum.
Super-Saturation
Salvo utilizes a volatile:nonvolatile co-solvent vehicle to create a state of supersaturation, which helps compounds cross the exterior layers of the stratum corneum. As the volatile component evaporates on your skin, the solution becomes more concentrated, and eventually becomes super-saturated, resulting in increased thermodynamic ‘push’, and enhanced penetration.
