I found this one.
1: Altern Med Rev. 1998 Dec;3(6):461-3. Related Articles, Compound via MeSH, Substance via MeSH, Books, LinkOut
Erratum in:
Altern Med Rev 1999 Feb;4(1):9.
Methylcobalamin.
[No authors listed]
Methylcobalamin is one of the two coenzyme forms of vitamin B12. Evidence indicates this form of vitamin B12, in addition to having a theoretical advantage over cyanocobalamin, actually has some metabolic and therapeutic applications not shared by the other forms of vitamin B12. This monograph provides an overview of the pharmacokinetics of methylcobalamin, and will highlight the potential therapeutic relevance for Bell's palsy, cancer, diabetic neuropathy, eye function, heart rate variability, HIV, homocysteinemia, male impotence, and sleep disorders.
PMID: 9855571 [PubMed - indexed for MEDLINE]
Doesnt say anything about weather it helps or hinders the liver unfortunately.
And I also came across this:
1: J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85. Related Articles, Compound via MeSH, Substance via MeSH, Books, LinkOut
Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats.
Hoshi N, Yano H, Hirashima K, Kitagawa H, Fukuda Y.
The acute toxicity (in rabbits and rats) and the subchronic and chronic toxicities (in rats) of Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a potentially useful pharmaceutical excipient, were investigated. 1) In the acute toxicity study (single oral dose of 2.5 g/kg), no deaths or behavioral abnormalities were observed. Thus, LD50 is higher than 2.5 g/kg. 2) In the subchronic toxicity study (0.63, 1.25 or 2.5 g/kg daily as a single oral dose in the morning, 6 days per week (not Sunday) for 2 months), no significant behavioral abnormality was observed. There was some decrease in body weight gain in rats of both sexes, but the effect was not statistically significant. 3)In the chronic toxicity study (1.25 or 2.5 g/kg daily as a single oral dose in the morning, 6 days per week (not Sunday) for 6 months), no significant behavioral abnormality was observed. There was some decrease in body weight gain in male rats, but it was not statistically significant. 4)Various biochemical and physiological abnormalities in rats were noted in all groups (including the control groups) in the toxicity studies, but there appeared to be no significant dose-related finding attributable to the administration of HPMCAS.
PMID: 3841672 [PubMed - indexed for MEDLINE]
Niether of these really zoned in on what I was looking for, but it didnt seem like there were a whole lot of studies examining either of these two in the context of liver detox OR liver toxicity.
My "hunch" is that niether would be BAD for the liver, but it just seems that most of the medical literature I glazed over was examining those compounds role in treatment of OTHER conditions. For instance, I found a few M-colabamin studies investagating it's effect on reducing tumor growth.
Perhaps someone with more patience and or resources than I can find something more specific.