Safest/ Most studied SARMS

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  1. Safest/ Most studied SARMS


    I think its oretty clear Osta is the safest known sarm as it has undergone many trials/ still moving forward to be used to prevent muscle wasting in a certain type of cancer...

    That being said, what sarms come in second? I have done a bit of research and it appears LGD is the second most studied/ fewest sides. Does this seem to be the consensus, then perhaps RAD as the third safest/ most studied/ fewest sides?

    Thoughts?


  2. None
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  3. None of them are as strong as AAS, or have sides like AAS. They still have the possibility of shutdown though, which i didn't experience even at 25mg of LGD 8 weeks. But s23/yk11 definitely shutsdown, basically a steroid. Everyone here on the forums lookout for you, so be grateful for that. A lot of it in my opinion is scare tactics though. Sarms were ****, i got nothing out of them. But i've hit well past my genetic limit.

  4. Quote Originally Posted by Brya View Post
    None of them are as strong as AAS, or have sides like AAS. They still have the possibility of shutdown though, which i didn't experience even at 25mg of LGD 8 weeks. But s23/yk11 definitely shutsdown, basically a steroid. Everyone here on the forums lookout for you, so be grateful for that. A lot of it in my opinion is scare tactics though. Sarms were ****, i got nothing out of them. But i've hit well past my genetic limit.
    Didn't dose long enough or large enough

  5. Throw them in the same basket as AAS. They will shut you down all the same when dosed for maximum gains and sides are a plenty. There's enough logs out there to make up your own mind. The only advantage they offer is in terms of legality.
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  6. As Sarms have shown to shut you down, a proper cycle support product and liver support is good to have. CEL CYCLE ASSIST and CEL TUDCA are used by many respected members here on AM.
    Serious Nutrition Solutions Representative
    Jgntyce@seriousnutritionsoluti ons.com

  7. I have seen enough threads here about weird ED issues after SARM cycles to think that they're not nearly as benign as people want to think.

    I've only seen a handful of studies on any of them.... I'd recommend looking closely at the subjects and if they are similar to a young, healthy male. in most cases that doesn't appear to be the case.

  8. Quote Originally Posted by a4urza View Post
    Didn't dose long enough or large enough
    I dosed like that on purpose to see if there was any difference in 10mg ED vs 25 mg ED only thing i got on both was a little temp erectile dysfunction. But with AAS or Sarms you have to be ready to go limp towards the end of the cycle. But PCT right i came back to normal, everything was fine. I didn't get shutdown on 25mg which doesn't make sense. I wonder if you pass a threshold where the body just can't use anymore. Not sure, but whatever.

  9. Quote Originally Posted by Brya View Post
    I dosed like that on purpose to see if there was any difference in 10mg ED vs 25 mg ED only thing i got on both was a little temp erectile dysfunction. But with AAS or Sarms you have to be ready to go limp towards the end of the cycle. But PCT right i came back to normal, everything was fine. I didn't get shutdown on 25mg which doesn't make sense. I wonder if you pass a threshold where the body just can't use anymore. Not sure, but whatever.
    you took 25 mg/day of LGD for 8 weeks?

    that's pretty suppressive at 1 mg/day for 3 weeks....

    https://www.ncbi.nlm.nih.gov/pmc/art...1/figure/fig2/

  10. I would say Ostarine as the safest one, then LGD. The other sarms are not studies at all.

  11. Yeah, when i had bloods done for both 10mg and 25mg they were actually pretty identical except for LH levels. LH was down a bit more on 25mg by about .9 . But my test was suppressed by about 65% which is quite a bit, and 10mg only about 50% Which i was wondering if there's like a limit, cause you'd think i would have been shutdown at 25mg but nope only about a 15% extra decrease.

  12. Quote Originally Posted by Arkm2 View Post
    I would say Ostarine as the safest one, then LGD. The other sarms are not studies at all.
    Agreed... looking for some more info and perhaps sources for studies. I subconsciously recall osta and lgd being the most safe but cant dig up the info i found.

    Nobody is debating they are suppressive, this is a well known fact. I dont think of this as a major side effect, i am moreso concerned about GW causing cancerous tumors and S4 causing eye problems. I have taken osta and noticed no problems *shutdown aside* and the shutdown has given minimal noticeable side *only lowered libido*.

    Anyone have any studies or sources for long term sides or lack thereof?

  13. Quote Originally Posted by Davy25 View Post
    Agreed... looking for some more info and perhaps sources for studies. I subconsciously recall osta and lgd being the most safe but cant dig up the info i found.

    Nobody is debating they are suppressive, this is a well known fact. I dont think of this as a major side effect, i am moreso concerned about GW causing cancerous tumors and S4 causing eye problems. I have taken osta and noticed no problems *shutdown aside* and the shutdown has given minimal noticeable side *only lowered libido*.

    Anyone have any studies or sources for long term sides or lack thereof?
    GW doesn’t cause cancer and S4 causes temporary night blindness that stops when the S4 is discontinued. There are no long term studies on sarms. None are even out of clinical trials yet and most sarms never even make it that far into animal trials.
    *Don't message me for sources, I will not respond. Everything I post is fictional and is for entertainment purposes only.*

  14. This is all true, to an extent. Osta has made it past Phase II and scheduled for phase III for cachexia cancer. Ncbi gives a good analysis of Osta, which lead me to believe it is the safest. The GW debate of dosage versus metabolic rate is exactly that "up for debate". Personally anything that has been proven to cause cancer at any extent i would try to stay away from.

  15. Google LGD 4033 clinical trials to find the ncbi study.

    limited adverse effects shown and in a much more closely related study group than osta. LGD studied healthy men aged 21-50 whereas osta was studied men 40-65 who had cancer. Both had very positive results with limited adverse effects, but again as mentioned previously, limited to no long term studies are available.

  16. as you have stated, there is nothing known about the long term side effects which in all seriousness can be quite scary

  17. Quote Originally Posted by Brya View Post
    Yeah, when i had bloods done for both 10mg and 25mg they were actually pretty identical except for LH levels. LH was down a bit more on 25mg by about .9 . But my test was suppressed by about 65% which is quite a bit, and 10mg only about 50% Which i was wondering if there's like a limit, cause you'd think i would have been shutdown at 25mg but nope only about a 15% extra decrease.
    Interesting. cool data to have....

  18. Quote Originally Posted by Davy25 View Post
    This is all true, to an extent. Osta has made it past Phase II and scheduled for phase III for cachexia cancer. Ncbi gives a good analysis of Osta, which lead me to believe it is the safest. The GW debate of dosage versus metabolic rate is exactly that "up for debate". Personally anything that has been proven to cause cancer at any extent i would try to stay away from.
    I posted this on another thread.... one of my issues with GW is the marketing by the companies selling it is not accurate on the dosing when comparing rats and humans:

    "This article seems to explain this a little more clearly (to me, at least):

    http://www.ergo-log.com/calculatethehumandosage.html

    ^So if this is correct, then the SARMs/GW companies clearly don't understand what they're talking about, and are dispensing some rather unsafe information.

    i.e. : https://www.evolutionary.org/gw-501516-cardarine-cancer

    ^If my math is correct (which it might not be), the comparable dose is not 900 mg, but 145 mg for the amount that is likely to cause cancer..... "

  19. Quote Originally Posted by Davy25 View Post
    Agreed... looking for some more info and perhaps sources for studies. I subconsciously recall osta and lgd being the most safe but cant dig up the info i found.

    Nobody is debating they are suppressive, this is a well known fact. I dont think of this as a major side effect, i am moreso concerned about GW causing cancerous tumors and S4 causing eye problems. I have taken osta and noticed no problems *shutdown aside* and the shutdown has given minimal noticeable side *only lowered libido*.

    Anyone have any studies or sources for long term sides or lack thereof?
    one of the suppression issues we are seeing on threads here, is guys will have good bloodwork post cycle, yet are having serious ED issues. I'm not sure the reason, but there are TONS of guys complaining about this on AM....

    PCT Help

  20. Quote Originally Posted by CatSnake View Post
    one of the suppression issues we are seeing on threads here, is guys will have good bloodwork post cycle, yet are having serious ED issues. I'm not sure the reason, but there are TONS of guys complaining about this on AM....
    Noteworthy. And i absolutely agree with you SARM companies are spreading incredibly dangerous information.

    I have come across threads stating ED after sarm use *is this osta or SARMS in general?*. Also from what i understand libido is not a direct result from test, therefore i wonder what the catalyst for ED would be even while test levels are shooting up.

  21. A little cialis will go a long way in pct! Was something I always included into my pct but now use daily while doing blast and cruise, never an issue with swinging the wood. Cialis also helps with blood pressure and helps protect the prostate. Not saying this is the answer to everyone’s problems mentioned in that thread but the right ancillaries make all the difference on cycle and pct.
    *Don't message me for sources, I will not respond. Everything I post is fictional and is for entertainment purposes only.*

  22. Ostarine clinical trials

    Ostarine is very well studied

  23. Thank you! Ostarine really gives me confidence taking *while i am skeptical of the pharma industry as a whole, pharma in general is poison*. I am reluctant to put any other SARM in my body but given the in depth studies that have occured with Osta, the adverse effects seem marginal at this point.

    In the thread referenced they said osta was discontinued for any other clinical trials/ treatments and has "limited outlook for pharmacueticl treatments", but on GTx's page they are still pursuing multiple uses for enbosarm and you can follow the clinical trials on "clinical trials dot gov" or something, the link is on GTx website. Not to sound like dylan gemelli but that is pretty awesome.

  24. Well this is coming from a different perspective. About a year ago I did a normal AAS cycle of 500-700 mg/w and came off. I decided to use some SARMs in conjunction with my normal PCT of Clomid and hCG. I added in 20-40 mg Ostarine. It turned into mroe of an experiment over the 8 weeks. I added in Ligandrol for a few weeks during. Then ended with a taper of the Ostarine and bumping the Clomid back up to 50 mg/d. I am hypo from years if use and age but my testes came back to normal size as usual using the clomid even though Ostarine was present. Over the course I noted that OStarine had recomp effect at 20-40 mg/d with more dramatic effects at the higher end. When I added 20 mg/d Ligandrol I put mass back on. I was using a total of 60 mg/d of SARMs. At that level they worked similar to a mild steroid cycle. 10 weeks later my bloodwork was fine but test is still ~300 ng/dL as is normal for me off all TRT.

    So the conclusion for me is Ostarine is useful as a recomp compound and Ok for maintaining some mass gained during AAS use. Ligandrol as an addition turns the SARM stack into more of a light anabolic cycle. What I don't know is what happened to my bloodwork during but afterward 10 weeks later all was fine. I never had any side effects at all. At the very end I was only using 20 mg Ostarine and felt a little flat so there is probably a level at which effects take hold. AS a long time user of PEDs my break-through amoiunt is probably a little higher than someone with younger fresher or virgin system. For me I would say to use again 40 mg/d Ostarine would be effective.

  25. Quote Originally Posted by Brya View Post
    I dosed like that on purpose to see if there was any difference in 10mg ED vs 25 mg ED only thing i got on both was a little temp erectile dysfunction. But with AAS or Sarms you have to be ready to go limp towards the end of the cycle. But PCT right i came back to normal, everything was fine. I didn't get shutdown on 25mg which doesn't make sense. I wonder if you pass a threshold where the body just can't use anymore. Not sure, but whatever.
    Lol if you didn't gain from LGD you definitely didn't dose high enough or had some bunk product
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