Certain SARMs were developed as a treatment for muscle wasting in the elderly, as well as
accelerated muscle wasting brought on by various conditions, one being cancer cachexia. These types of accelerated muscle loss are as a result of a specific disease that either blocks the normal process of muscle repair or causes an inability to maintain body weight for other reasons or chronic conditions outside of normal health.
Taking a research chemical under normal health conditions to "stave off" muscle wasting over a period of 2-3 weeks is foolish. He will not lose any mature muscle tissue in that time period, assuming he is not bed-ridden and malnurished. Any mass lost during that time period will likely be storage of "excess" muscle glycogen.
The clinical trials for Ostarine were conducted with doses ranging from 0.1 to 3mg, and the 3mg dose showed varying degrees of suppression of various hormones. Using doses of almost double or more than triple that which were studied will surely lead to increased suppression. These same trials also showed a lowering of HDL (good cholesterol) at ALL doses ranging from 0.1 to 3mg. Liver strain was also noted by a change in measured liver values. Using Ostarine for 3-4 weeks is indeed less than the studied duration that showed the negative symptoms but the doses far exceed what was used in clinical trials. Some people will argue that low doses don't have a large impact on LH/FSH. Regardless of whether or not the suppression will be minimal or severe, why would anyone choose to suppress themselves, to any degree, and with a research chemical, to stave of muscle wasting that is NOT going to happen over a period of 2-3 weeks? This makes no sense at all. There are "natural" supplements that can be taken that will increase protein synthesis and at the same time not cause suppression of Testosterone levels or negatively impact lipid profiles.
Suppression caused by usage of exogenous androgens, or androgen 'mimetics', will begin to take place as soon as the negative feedback loop is initiated and downstream hormones are negatively affected. The degree of that suppression will depend on dose and duration of use. Saying that suppression will only begin to happen after or around 4 weeks is not accurate. Degree of suppression (below baseline) and ability to recover quickly are different topics.
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Ostarine
Rad-140