Kidney damage from orals

Punkrocker

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Ok so I'm aware of liver issues linked to oral anabolics due to the methylation and the liver stressing to break down the compound and what not. My question is, what is the science behind kidney damage from the use of oral steroids? I've heard many people say that drugs like Dianabol and Anadrol wreak havoc on the kidneys. How exactly do they damage the kidneys? Could somebody please explain the science?
 

WolfJFlywheel

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i dont know the science but ive seen a few smart people mention it so i always throw in some cranberry extract caps
 
Punkrocker

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i dont know the science but ive seen a few smart people mention it so i always throw in some cranberry extract caps
But that's the thing! Would be nice to know what the mechanism of injury to the kidneys is from oral steroids so we can better understand what we are doing to ourselves and how to prevent it
 
ChocolateClen

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Basically the kidneys get rid of 20% or everything that passes through them, good and bad. Then it goes back and picks up the good stuff. This allows it to get rid of stuff that it doesn't know or recognize as bad. Now I'm not 100% sure but I assume steroids damage the "filters" in the kidneys so instead of 20% of everything being kicked out, it becomes higher and then the kidneys have to work harder to go back and pick everything up. If enough damage happens the kidneys won't be able to pick everything up that leaks out, and there's a possibility that larger molecules like blood cells etc could leak out.

Sources are physiology from a year ago. But we didn't talk about steroids so I could be wrong
 
Punkrocker

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Basically the kidneys get rid of 20% or everything that passes through them, good and bad. Then it goes back and picks up the good stuff. This allows it to get rid of stuff that it doesn't know or recognize as bad. Now I'm not 100% sure but I assume steroids damage the "filters" in the kidneys so instead of 20% of everything being kicked out, it becomes higher and then the kidneys have to work harder to go back and pick everything up. If enough damage happens the kidneys won't be able to pick everything up that leaks out, and there's a possibility that larger molecules like blood cells etc could leak out.

Sources are physiology from a year ago. But we didn't talk about steroids so I could be wrong
Well at least we're starting with something. I have heard numerous times about guys who used to be serious bodybuilders and now are on dialysis and supposedly steroids are to blame. I really would like some insight on this it is very interesting
 
Punkrocker

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The researchers proposed that extreme increases in muscle mass require the kidneys to increase their filtration rate, placing harmful levels of stress on the kidneys. “As in obese patients, the increased strain on the kidney from the elevated body mass leads to hyperfiltration injury,” Dr. Herlitz explained.

Looks like just being jacked is bad for your kidneys. God damnit
 

sespress

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The researchers proposed that extreme increases in muscle mass require the kidneys to increase their filtration rate, placing harmful levels of stress on the kidneys. “As in obese patients, the increased strain on the kidney from the elevated body mass leads to hyperfiltration injury,” Dr. Herlitz explained.

Looks like just being jacked is bad for your kidneys. God damnit
Well crap. That'll save me on my gym membership at least =)

I've even heard creatine and protein will increase the load on them too.

Perhaps this is another instance of moderation is suggested!
 
hairygrandpa

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The researchers proposed that extreme increases in muscle mass require the kidneys to increase their filtration rate, placing harmful levels of stress on the kidneys. “As in obese patients, the increased strain on the kidney from the elevated body mass leads to hyperfiltration injury,” Dr. Herlitz explained.

Looks like just being jacked is bad for your kidneys. God damnit
One more reason to get lean. I bet the high prot diet is doing most of the damage.
 

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One reason orals are hard on kidneys is because they jack up your blood pressure which inflames the prostate and causes excessive urinating and not being able to fully empty etc
 

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In a nutshell, some steroids can jack up your blood pressure. High blood pressure can damage the vessels feeding the kidney tissue. The kidneys play a major role in regulating blood pressure, and the damaged kidneys won't be able to bring the pressure down by regulating blood volume. In fact, the kidney will sense "dehydration," and will respond by trying to raise blood pressure through the secretion of renin (I think... it's been a long time since I had to know this stuff).
 
ChocolateClen

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In a nutshell, some steroids can jack up your blood pressure. High blood pressure can damage the vessels feeding the kidney tissue. The kidneys play a major role in regulating blood pressure, and the damaged kidneys won't be able to bring the pressure down by regulating blood volume. In fact, the kidney will sense "dehydration," and will respond by trying to raise blood pressure through the secretion of renin (I think... it's been a long time since I had to know this stuff).
Sounds about right from what I remember from phisiology class. I'll ask my exercise phys teacher next class why.
 

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Past cycle in 2015 I think.. deca test dbol..
I had high liver enzymes and kidneys were showing levels off.. Dr sent me to kidney specialist(main concern).. they ran bloodwork he asked of course what I was taking I told him "OTC supplements"..
His words were that steroid use and OTC supps damaged kidneys by making them work harder and higher than normal, creatine levels also damage kidneys (I had high creatine levels too) also high protein intake damage kidneys too. And hard workouts put stress on kidneys.. so basically he said heavy training and supplement use combined with high protein, anabolic use put this stress in my liver and kidneys. I laid off working out a total of 3 months flat. He said no weights no cardio. Returned for blood work and I was good again. All levels returned to normal. Thank God.
Gainz come with a toll unfortunately
But then again he said everyone responds differently..

I'm in pct now from a test tren cycle, I'll check kidney levels after pct to see how they are. But I feel better overall this cycle.
 

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Oh yea he said no hard liquor, but I could drink beer lol.. I only drink beer, coffee & water
 

user567

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Orals cause high blood pressure. So does AAS

The nephrons in the kidneys are supplied with a dense network of blood vessels, and high volumes of blood flow through them. Over time, uncontrolled high blood pressure can cause arteries around the kidneys to narrow, weaken or harden. These damaged arteries are not able to deliver enough blood to the kidney tissue.
 
yates84

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Liver and kidneys are directly related as well. Liver health is key for kidney health.
 

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I think creatinine levels are what is meant, but that is not unusual when you get bigger and are working out. When you start finding protein in your piss, then you may need to worry about your kidneys. Of course, that is just one instance of worrying about kidneys
 

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Hmm is the main identier of an issue the creatine count on a metabolic panel?
 

sarge40

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High creatinine levels around here are likely the result of creatine being metabolized to creatinine in muscle tissue. High creatinine associated with lifting may not be bad, unless your BUN/creatinine levels are out of range. My creatinine levels are typically in the 1.4 range (1.2ish being the high end of normal) but my BUN/creatinine levels are good. High creatinine levels in inactive subjects may be indicative of low clearance due to kidney damage though.
 

sarge40

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Hmm is the main identier of an issue the creatine count on a metabolic panel?
Remember that creatine and creatinine are different, but related. It's not the only marker to look for as I indicated in my previous post. Another marker that may be indicative of problems, in addition to the BUN/creatinine level, is a low glomerular filtration rate (GFR)
 
Punkrocker

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Interesting about creatinine. My BUN is always high like in the mid 20s and my creatinine had been like 1.3 but the doctors then check my urine and egfr and say that my kidneys are fine and it's probably a combination of dehydration and high protein diet plus weight training which causes higher levels of creatinine kinase. Well from everything I'm seeing from you guys, it seems that steroids alone are not the culprit in kidney damage but only a mere fraction of the numerous things involved in stressing the kidneys due to the bodybuilding lifestyle. Basically seems like bodybuilding is bad for the kidneys. That's my conclusion.
 

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Most doctors should know by looking at you that if your creatinine is a little high, it is typical of someone of a bigger stature. Mine is over by a little bit, but based on the body type, they understand it to be normal given the circumstances. That post above about high creatinine in a couch potato is right on and can be red flag
 
Punkrocker

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Most doctors should know by looking at you that if your creatinine is a little high, it is typical of someone of a bigger stature. Mine is over by a little bit, but based on the body type, they understand it to be normal given the circumstances. That post above about high creatinine in a couch potato is right on and can be red flag
The one thing I've noticed is that my BUN is always elevated! The range is 6-20 and mine is always 26 or 30. Once it was high as 36! But the docs have ran tests and checked other markers of my kidney function and said my kidneys are fine so I dunno.
 

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It's interesting that you mention creatine kinase (sometimes referred to as CPK - creatine phosphokinase) markers. Another problem, unrelated to the kidney issue, is that people who train hard may experience high AST and ALT levels. A lot of docs don't realize that muscle trauma can jack these levels up. One way to evaluate whether it's truly liver-related is by testing CPK. High CPK from lifting heavy generally points to the elevated LFTs being from muscle trauma, not liver damage. Thought it is worth mentioning since some guys here might experience this problem, or might have some concerns with LFTs due to oral dosing.
 

sarge40

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Also, your high BUN is likely due to the excessive (not by our standards tho) intake of protein, resulting in high levels of nitrogen in the body.
 

sespress

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It's interesting that you mention creatine kinase (sometimes referred to as CPK - creatine phosphokinase) markers. Another problem, unrelated to the kidney issue, is that people who train hard may experience high AST and ALT levels. A lot of docs don't realize that muscle trauma can jack these levels up. One way to evaluate whether it's truly liver-related is by testing CPK. High CPK from lifting heavy generally points to the elevated LFTs being from muscle trauma, not liver damage. Thought it is worth mentioning since some guys here might experience this problem, or might have some concerns with LFTs due to oral dosing.
Interesting again, I took blood recently and had high ast/alt and had someone tell me that a real number you need to have not trained hard for like a day or so to get an accurate number.
 
Punkrocker

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Also, your high BUN is likely due to the excessive (not by our standards tho) intake of protein, resulting in high levels of nitrogen in the body.
Yeah for the past 3 years on all my blood tests my BUN has always been anywhere from 24 to 36. I don't think it's ever been within normal range. I dunno man. I'm still here though. Lol
 
yates84

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Yeah for the past 3 years on all my blood tests my BUN has always been anywhere from 24 to 36. I don't think it's ever been within normal range. I dunno man. I'm still here though. Lol
Just be aware of your higher levels and take care of yourself according. If you are being proactive about your health then you will be ok, keep doing your routine blood work and cycle accordingly. Out of range a few points is not a death sentence but definitely continue to respect your numbers as you have been doing. You are cycling right bro, much respect to you for that.
 

sarge40

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Interesting again, I took blood recently and had high ast/alt and had someone tell me that a real number you need to have not trained hard for like a day or so to get an accurate number.
It might take a little longer than that to get an accurate test result. Ask your doc for a CPK test. I guarantee it's off the charts. High CPK doesn't conclusively rule out liver disease, but it's an indication that muscle trauma is at least a contributing factor, and you're training hard, likely the main factor.
 
yates84

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Elevated AST/alt means absolutely nothing. A few points above range is not indicative of anything.
 

user567

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Yeah for the past 3 years on all my blood tests my BUN has always been anywhere from 24 to 36. I don't think it's ever been within normal range. I dunno man. I'm still here though. Lol
I have had high BUN values for 5 years, around 30 every blood test. So finally I wanted peace of mind. I bought a supplement called Kidney Stuff, stopped protein (and creatine) 24 hours before latest blood test and drank ton of water. BUN came back at 17. Mind at ease
 

sespress

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Elevated AST/alt means absolutely nothing. A few points above range is not indicative of anything.
A few points? Try triple the reference range. All other numbers normal. Didn't get that other test done but hitting 300 made me decide to cut the orals short. I'm ending my current cycle on the 3rd. I don't want to derail with details on all of that, but I will see what the cpk panel costs as I'll be pulling a normal metabolic panel just as I end. I'm trying to get a really good feel for my before during after and just how exactly the oral stuff was effecting me. Perhaps though I've not pulled enough of the right numbers.

So what would you get on a panel and how when would you have blood drawn (how long after training, while on oral, etc...)

Edit:
Replied to Yates but want sarge40 to give me his thoughts also
 
jameschoi

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would msten count as damaging to your liver/kidneys.
 
yates84

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That, my friend, is a solid reason to never touch orals again. No disrespect intended.
 

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Based on past experiences, I personally would wait a couple of months after stopping, as long as you're asymptomatic. 300 is actually not that high of an elevation, if acute (even though it's about 6X high end of normal), but you want to make sure it goes down when off orals. I'd do the typical LFT bloodwork (AST, ALT and alkaline phosphatase) with the CPK. If you're training on a regular basis, even with a few days off it will likely be elevated. If the CPK is sky high, it would explain elevated AST and ALT. Remember that these are just indicators, and your doc will determine if anything concerns him. You'll probably be okay after the liver gets a rest.

BTW, are you checking stool color when you drop a deuce? Light colored stool (khaki/clay to white [yes, white] colored) can be an indication of a biliary obstruction which could be caused by liver problems. Just something to check periodically, even when everything else looks good.

If your elevations are chronic, your doc may script you an ultrasound of the liver and/or refer you to a gastroenterologist to check you out. Only then are you getting closer to a conclusive answer. I have a feeling that when you're off the orals and you see your CPK numbers, everything will make sense and you'll be G2G. Good luck!
 

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That, my friend, is a solid reason to never touch orals again. No disrespect intended.
None taken, I'm not keen on this side effect. I've already decided to run injectables down the road. My numbers were fine before cycle. I've got a close eye on it. I'll be checking for them to clear.
 

sespress

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Based on past experiences, I personally would wait a couple of months after stopping, as long as you're asymptomatic. 300 is actually not that high of an elevation, if acute (even though it's about 6X high end of normal), but you want to make sure it goes down when off orals. I'd do the typical LFT bloodwork (AST, ALT and alkaline phosphatase) with the CPK. If you're training on a regular basis, even with a few days off it will likely be elevated. If the CPK is sky high, it would explain elevated AST and ALT. Remember that these are just indicators, and your doc will determine if anything concerns him. You'll probably be okay after the liver gets a rest.

BTW, are you checking stool color when you drop a deuce? Light colored stool (khaki/clay to white [yes, white] colored) can be an indication of a biliary obstruction which could be caused by liver problems. Just something to check periodically, even when everything else looks good.

If your elevations are chronic, your doc may script you an ultrasound of the liver and/or refer you to a gastroenterologist to check you out. Only then are you getting closer to a conclusive answer. I have a feeling that when you're off the orals and you see your CPK numbers, everything will make sense and you'll be G2G. Good luck!
No other symptoms I'm also certain they'll go down in PCT. Poop is normal lol. I'll check for that panel next test I get.

I didn't want to derail things, would you say that if liver enzymes run high the kidneys also then get involved too much? I read that really dark urine can be a sign of liver stress as well and if it's crazy dark the kidney probably is not happy either.

And as an organ the liver I know can regenerate but I don't know what kind of healing qualities the kidneys​ posses. Organs that filter should be durable, the lungs are incredibly durable considering what they put up with for how long. People drink hard for years, decades, before the liver gets toasted fully. The kidneys must be able to heal up quickly. If that is correct then it is a question of how much and how often they're overloaded. If just working out is stressful on them it seems like they don't get much of a break to begin with. Maybe planning some kind of period line a week long at least every few months where you just chill, eat veggies mostly and take no supps or anything else. Like a full system deload. I Wonder what that would look like.
 

user567

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No other symptoms I'm also certain they'll go down in PCT. Poop is normal lol. I'll check for that panel next test I get.

I didn't want to derail things, would you say that if liver enzymes run high the kidneys also then get involved too much? I read that really dark urine can be a sign of liver stress as well and if it's crazy dark the kidney probably is not happy either.

The kidneys must be able to heal up quickly. If that is correct then it is a question of how much and how often they're overloaded. If just working out is stressful on them it seems like they don't get much of a break to begin with. Maybe planning some kind of period line a week long at least every few months where you just chill, eat veggies mostly and take no supps or anything else. Like a full system deload. I Wonder what that would look like.
The kidneys do not heal like the liver. When they go they go! Be careful with your kidneys.
 

sespress

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The kidneys do not heal like the liver. When they go they go! Be careful with your kidneys.
Oh no I understand nothing does. Liver regenerates, everything else but bone scars. What I'm wondering is if even without supplements or gear involved if the kidneys are under stress just from hard training and high protein, maybe it should become a thing where every so often you just go vegan for a week and play video games. I know that sounds strange but think about it. Take the stress off of the system. The human body owes most of its traits to like millennia of a cave man named Ugnh hunting for food, protecting the tribe, and running away from saber tooth tigers. The way metabolising changes based on how and what you eat, it's all inbred survival traits. Even Ungh had times when he had to just sit tight, wait, eat only what he gathered and try to find a new hunting ground. This is all like a personal theory I have, not prescribing to the Paleo diet but in that same logic I think maybe there's a good lesson? Trying to take a break from a mega protein diet with 4-5 hours of lifting per week just occasionally? Anyone feel me? Lol I'm like rambling on. Poor Ungh had no video games to play.
 
heavylifter33

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This thread makes my head hurt. Not a single piece of empirical data was seen.
 

user567

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Oh no I understand nothing does. Liver regenerates, everything else but bone scars. What I'm wondering is if even without supplements or gear involved if the kidneys are under stress just from hard training and high protein, maybe it should become a thing where every so often you just go vegan for a week and play video games. I know that sounds strange but think about it. Take the stress off of the system. The human body owes most of its traits to like millennia of a cave man named Ugnh hunting for food, protecting the tribe, and running away from saber tooth tigers. The way metabolising changes based on how and what you eat, it's all inbred survival traits. Even Ungh had times when he had to just sit tight, wait, eat only what he gathered and try to find a new hunting ground. This is all like a personal theory I have, not prescribing to the Paleo diet but in that same logic I think maybe there's a good lesson? Trying to take a break from a mega protein diet with 4-5 hours of lifting per week just occasionally? Anyone feel me? Lol I'm like rambling on. Poor Ungh had no video games to play.
Absolutely, try to find Dave Palumbos detox program for your kidneys, he goes in to detail about how to do this. He recommends the supplememt Kidney Stuff and then following a 2 week cleanse etc..
 

sespress

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Absolutely, try to find Dave Palumbos detox program for your kidneys, he goes in to detail about how to do this. He recommends the supplememt Kidney Stuff and then following a 2 week cleanse etc..
Thank you I'll check that out!
 
FRITZBLITZ

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One more reason to get lean. I bet the high prot diet is doing most of the damage.
Not being jacked that is tough on kidneys...its the cholesterol that carries you do require to keep insane AA chem signals going to your receptors and cells.
 
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Along with your choice kidney detox **** add about 2x Potassium because this helps all the **** your body "will get around to" to dump while your kidneys are at peak function. Also If you take about 300% of DV Potassium and cranberrry with decent water it's 1 of the best anti-inflammitory you can do, works best on estremities but it will turn a grapefruit size akle normal in 2 days
 

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Along with your choice kidney detox **** add about 2x Potassium because this helps all the **** your body "will get around to" to dump while your kidneys are at peak function. Also If you take about 300% of DV Potassium and cranberrry with decent water it's 1 of the best anti-inflammitory you can do, works best on estremities but it will turn a grapefruit size akle normal in 2 days
You take potassium citrate?
 
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You take potassium citrate?
I've used all different types but I think...citrate is most absorbed but honestly whatever is cheapest cuz it takes a lot. most Potassium is 3-15% DV per cap. When I came up with this trick I set my diet at 100% Potassium then added about 50%DV 3 times a day so whatever that works out in mg depends on what you buy, but for anti-inflammatory it seems like 8 pills 3 times a day and you have to drink the real 100% cranberry juice not oceanspray cocktail.
 

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