Right but if you wait the full 12 hours you're going from having 100%-0 back to 100%. Wouldn't it be better to just dose 4 times that way you always have at least 50% in your body, wouldn't it be easier on your body?
That's not quite how it works. First, the (plasma) half-life of a particular compound will vary from person to person depending on metabolism and overall health (liver/kidneys etc.) Second, if a compound has a 6 hour half-life, that means at 1 half-life (6 hours) there is ~ 50% left in the bloodstream. After 2 half-lives (12 hrs.), there should be ~ 25% left in the bloodstream. After 3 half-lives (18 hrs.), there should be ~ 12.5% left in the blood stream. Etc. Etc. It is generally assumed that 5 half-lives is the best guess for almost complete elimination from the bloodstream.
Of course, when a drug has been fully eliminated from the bloodstream, it does not mean that the effects of the compound cease to exist. Depending on the compound in question, it may have bonded with a specific protein or receptor and biological functions may take place over a period of time. Depending on the action of the compound itself, it may induce a certain "state" that if left alone may take the body days to balance out after. If the compound in question inhibited a certain protein or enzyme, the body would then have to manufacture a new one in place of it. The process does not reach full circle immediately.
There is definitely something to be said for maintaining stable blood levels of whatever it is you are taking. For a SARM with a 6 hr. half-life you could dose 2 or 3 times per day. Either would work just fine. Consider that there is something to be said for drug accumulation within the body, as we add more and more doses. Meaning, there is always some of the old dose left over when we add subsequent doses thereafter.
For example, if we were to take 10mg of the above-mentioned SARM (with a suggested 6 hr. half-life) every 12 hours (2x per day) we would be left with the following blood plasma levels (approximation).....
After 12 hours (2 doses), we would have 12.5mg in the blood stream.
After 24 hours (3 doses), we would have 13.125mg in the blood stream.
After 36 hours (4 doses), we would have 13.28mg in the blood stream.
After 48 hours (5 doses), we would have 13.32mg in the bloodstream.
After 60 hours (6 doses), we would have 13.33mg in the blood stream.
As you can see, it doesn't take long for steady plasma levels to be reached with 2x daily dosing.
I have attached a little graph for entertainment value. The top line indicates hour intervals. The numbers (10) on the left indicate doses of 10mg every 12 hours.
