Just wondering what would be the best test base to keep libido up while on an 8-12 week cycle of LGD?
Not true. It will work for you young cats as well. Dermacrine is suppressive but is very very mild imo.I have heard that using dermacrine as someone younger than about 30 will not be as effective, is there any truth to this?
Mind explaining why it's suppressive? It's jsut DHEA and pregnenolone mixed with 2-3 AI's which should amp up your own production?Not true. It will work for you young cats as well. Dermacrine is suppressive but is very very mild imo.
They're the father and mother hormones yes, however is still endogenously producing the testosterone itself therefore the dhea would just cause your body to produce more of it's own testosterone, same way T-boosters work... and i would hardly call t-boosters prohormones.DHEA and progesterone it contains are pro hormones
Also it uses pregnenolone no progesterone.DHEA and progesterone it contains are pro hormones
Well there you go, if it doesn't increase our tesosterone production how is it suppressive? DHEA and testosterone have an entirely different molecular structure so why would our body tell the HPTA to down regulate test when excess DHEA is present? Only down side i can see is the DHEA converting to estrogen and then Dermacrine has AI's in it so if anything it seems like it'd help the endrocrine system rather than disrupt, am i incorrect in thinking so?I don't think Exogenous transdermal DHEA will increase body's own test production. And you are right pregnenolone, not progesterone
How does it cause down-regulation? It's the father hormone therefore your body uses it to makes its OWN hormones, Im not arguing simply trying to learn and appreciate any input.I think you just made my point, it's an Exogenous hormone that cause's down regulation of HPTA. The DHEA is said to covert to androstenedione/diol then to test
I didn't say it IS one i said it can be CONSIDERED one.Vitamin D is NOT a prohormone.
It is not a prohormone but is synthesized into one,by who? Because everywhere else its considered a Vitamin.
So in Essence my initial statement of it being "Like/Considered" a pro-hormone has some true holding, as does your statement that it's a vitamin. However both of our initial statements are incorrect as you've stated it's more than a vitamin, less than a hormone and in fact is a "Biomodulator Vitamin." Thank you for the read, I always enjoy expanding i'm aware this has actually been a controversial topic. More excerpts to add to my log. Reps.The Vitamin D process involves roughly that:
(1) the liver readily hydroxylates vitamin D – using cytochrome P450 enzymes –in to 25(OH)D, the primary circulating form of vitamin D,
(2) then the kidney further hydroxylates 25(OH)D into the active form 1,25-dihydroxyvitamin D which is also referred to as 1,25(OH)2D, which then acts to maintain serum calcium through sequential direct effects on calcium absorption and excretion, and through a complex series of inter-relationships with serum phosphate and parathyroid hormone.
But there are two hormonally-active substances, known as (fat-soluble) secosteroids, derived - and distinct - from Vitamin D (either D2 or D3), these being:
(1) 1,25-dihydroxyvitamin D (calcitriol) which is a calcium-regulating hormone, an adaptive hormone produced in response to calcium deficiency, it functions the same way as other steroid hormones, namely by interacting with its cognate vitamin D receptor (VDR);
(2) 25-hydroxy-VitaminD which is a prehormone (not a prohormone), a glandular secretory product, having minimal or no inherent biologic potency, that is converted peripherally to an active hormone.
However, 1,25-dihydroxyvitamin D (calcitriol) which is the metabolic product of vitamin D, is itself a potent, pleiotropic repair and maintenance secosteroid hormone acting as a a molecular switch targeting over two hundred known human genes across a wide variety of tissues2, and functions as an adaptive hormone (being produced in response to calcium deficiency).
The actions of 1,25-dihydroxyvitamin D (calcitriol) are mediated by the Vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression, 1,25-dihydroxyvitamin D (calcitriol) thus serving as a transcriptional regulator of various genes2. Indeed, recent data shows that 1,25-dihydroxyvitamin D (aka, 1,25(OH)2D)-activated VDR modulates the expression of genes at both single gene loci and also at the level of gene networks3,4,5.
Given, as I have demonstrated above, that:
(1) Vitamin D is a vitamin, with
(2) 25-hydroxy-VitaminD being a prehormone (a glandular secretory product converted peripherally to an active hormone, namely 1,25-dihydroxyvitamin D (calcitriol); while
(3) 1,25-dihydroxyvitamin D (calcitriol) is a secosteroid hormone functioning as a a molecular switch which is known to target over two hundred known human genes, and thus serves as a transcriptional gene regulator,
then I would argue that we need to construe Vitamin D itself as something more than a vitamin but less than a strict hormone (that function being reserved for 1,25-dihydroxyvitamin D (calcitriol)), in order to reflect and accommodate its gene transcriptional regulator functions, and so it would be more clarifying to speak of Vitamin D as not a simple vitamin, but rather as a biomodulator vitamin, a vitamin which exerts transcriptional regulation of genes at the molecular pathway level.
Summary
- Vitamin D itself - neither cholecalciferol (Vitamin D3) nor ergocalciferol (Vitamin D2) - is not a hormone, but rather a biomodulator vitamin (capable of gene regulation);
- the primary active form 1,25-dihydroxyvitamin D (calcitriol) is a calcium-regulating hormone;
- the primary circulating non-active form 25-hydroxy-VitaminD is a prehormone, converted peripherally to the active hormone 1,25-dihydroxyvitamin D (calcitriol).
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