SAMe vs milk thistle and ALA... SAMe wins every time. Dr. D posted some great info on SAMe on this site, however i don't know what's become of it. Remember with SAMe you want to dose away from c17 orals.
There seem to be a couple decent sources of TUDCA floating around now, so i typically go with that. I stopped buying TUDCA after the planet ran out and Omega had some quality issues. Now that CEL is making TUDCA i'm backing buying it. Only buy TUDCA from trusted sources. My on-cycle support now consists of TUDCA and Cycle Assist both from CEL. Comprehensive protection right there.