GW501516 and cancer?

[pogue]

So, I noticed the Wikipedia entry on GW501516 mentions that this compound was abandoned as a research chemical by the mfg because it caused cancer in the animals they were testing it on. Thoughts on this?

GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol[1]) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.

By 2007, GW501516 had completed two phase II clinical studies and other studies relating to obesity, diabetes, dyslipidemia and cardiovascular disease,[9][10] but GSK abandoned further development of the drug in 2007 for reasons which were not disclosed as the time.[11] It later emerged that the drug was discontinued because animal testing showed that the drug caused cancer to develop rapidly in several organs.[12][13][14]

From the references:

Despite these promising early results, the further investigation and development of GW501516 was discontinued after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes

I can't post the URLs but its on the Wikipedia entry.

 

[TheMovement]

Search out Q&A thread and your answers there

 

[hamdysayed]

So, I noticed the Wikipedia entry on GW501516 mentions that this compound was abandoned as a research chemical by the mfg because it caused cancer in the animals they were testing it on. Thoughts on this?



From the references:




I can't post the URLs but its on the Wikipedia entry.

I think they used enormous amount on the lab animals, that's why it caused cancer.
but hopefully someone with more knowledge can elaborate more

 

[pogue]

Search out Q&A thread and your answers there

Can you elaborate as to where I can find this?

I think they used enormous amount on the lab animals, that's why it caused cancer.
but hopefully someone with more knowledge can elaborate more

That seems to be what I'm reading on the talk page of Wikipedia, there is a lot of back and forth about the dosage used, etc. But, I think it boils down to the question of: why would a major pharmaceutical company abandon research and usage of the compound and why would they do this specifically after studies showed it caused cancer in lab animals?

 

[bighulksmash]

TUDCA PCT cancer stuff

What?

 

[yates84]

http://anabolicminds.com/forum/steroids/270011-sarms-mk-gw.html
We touched on this subject once or twice in my users guide thread. Cancer is not going to be a risk at the doses that we are consuming (5 to 20mg) and the length of time we are using (4 to 12 weeks). GW is safe when used in moderation imo.

 

[T-Bone]

...because cancer needs to be protection

 

[bighulksmash]

You can use TUDCA to protect cancer.

What the fakkkkkk ??? Tudca will not protect you from cancer. Iam taking a nap thats the statement of the century. Goooood night!

 

[T-Bone]

It was thought that cancer was only caused in larger doses, but there were studies showing it can cause cancer at any dosage. That is why they dropped the drug and stopped the studies.

 

[Chrisko]

If it does case cancer at any dose, why would anyone want to take it? **** that.

There has to be a good reason why research companies abandon a compound. Pharmaceutical companies are all about making money. Think about it. The value of the drug is no where near the cost of the side affects to them. Hence why some go on to be patented and others don't.

 

[Chrisko]

Unless someone else can explain better reason to drop research on a compound other than funding.

 

[aovereem]

Its beyond me why anyone would even gamble with this ****

 

[T-Bone]

If it does case cancer at any dose, why would anyone want to take it? **** that.

There has to be a good reason why research companies abandon a compound. Pharmaceutical companies are all about making money. Think about it. The value of the drug is no where near the cost of the side affects to them. Hence why some go on to be patented and others don't.

Just because it can cause cancer, doesn't mean it will. A lot of things can cause cancer. Doesn't mean they WILL cause cancer.

 

[Chrisko]

Yeah, you can bang a chick or dude(whatever anyone is into) with a condom that has hiv or AIDS. It doesn't mean you will get it but do you want to take that chance?

 

[mountainman33]

There are studies that show too much creatine can cause cancer. Enough vitamin C can cause cancer. It's all about staying under super human dosing.

 

[pogue]

There are studies that show too much creatine can cause cancer. Enough vitamin C can cause cancer. It's all about staying under super human dosing.

There is no such study.

 

[StanleyG]

It was thought that cancer was only caused in larger doses, but there were studies showing it can cause cancer at any dosage. That is why they dropped the drug and stopped the studies.

Exactly. So even at a reasonable HED GW has the very real potential to be unsafe. Given its sketchy & inconsistent benefits it is far from a compound worth using IMO.

 

[hamdysayed]

Exactly. So even at a reasonable HED GW has the very real potential to be unsafe. Given its sketchy & inconsistent benefits it is far from a compound worth using IMO.

can you clear your inbox man!

 

[berazzled]

Wtf

 

[bighulksmash]

Wtf

Its good to research this new things ... ill stick to my 3 ph blends or test Tren mast im ... no sarms or rcs for me ever

 

[heckler7]

my experience was this stuff is fake, and havent read a log yet where someone said it worked as advertised. I suggest you spend your hard earned dollars on clen

 

[berazzled]

my experience was this stuff is fake, and havent read a log yet where someone said it worked as advertised. I suggest you spend your hard earned dollars on clen

Maybe you should check some logs on here bro.

 

[yates84]

my experience was this stuff is fake, and havent read a log yet where someone said it worked as advertised. I suggest you spend your hard earned dollars on clen

That's a very generalized statement. I could link multiple logs right now to gw users that will say that it does work as advertised. Looks like you need to do some more research next time before spending your hard earned dollars

 

[heckler7]

That's a very generalized statement. I could link multiple logs right now to gw users that will say that it does work as advertised. Looks like you need to do some more research next time before spending your hard earned dollars

actually its an opinion based on my experience and I feel it makes a valid point, you rum a pretty good risk at getting bunk chems, I did thats a fact. I will never purchase GW again

 

[Toren]

actually its an opinion based on my experience and I feel it makes a valid point, you rum a pretty good risk at getting bunk chems, I did thats a fact. I will never purchase GW again

When you say "this stuff", people will tend to assume you mean all GW. Your statement comes across as generalized and non-specific. If you had said 'my stuff was fake' or, 'the GW I took was fake', then yates would have given you the leeway you are suggesting you should have gotten. No one is debating the fact that you had a negative experience with the stuff you took. Nobody is suggesting that all GW on the market is legit. The way you worded your statement could sugggest that you think all GW supps are fake. I'm just giving you some perspective from a neutral party.

I have been on GW since Aug. 13 and I can tell you it does what it is supposed to do. There is no doubt the variance on that result will be dependent on so many factors. It is by no means a miracle worker though. I view it not as a staple supplement but as an addition to a supplement and training program. Nothing will outwork hard work!

 

[heckler7]

I hear what your saying bro, I'm just not fond of peptides in general, seems like I got scammed by 2 different labs. I think that for the same money there are other products that perform as .

 

[Toren]

I hear what your saying bro, I'm just not fond of peptides in general, seems like I got scammed by 2 different labs. I think that for the same money there are other products that perform as .

Fair enough. We all make decisions based upon our past experiences.

 

[T-Bone]

I really haven't seen a lot of positive posts about GW. Well maybe a few with someone taking 5 other things. Much better safer things you can spend your money on.

 

[DirtyWilly]

I'd run an I.V. tap of Cardarine if I could; the stuff is too good to be true. The problem I have is when you give 400 times the dosage of LGD, Osta, MK, etc to mice they don't develop cancer. With Cardarine they did. I also used to chewed tobacco for 15 years so take it for what it's worth.

 

[T-Bone]

Too good to be true because it doesn't deliver on the results claimed. Well maybe it does, if it's a sponsored log....

 

[BamBam0319]

Too good to be true because it doesn't deliver on the results claimed. Well maybe it does, if it's a sponsored log....

All I can say is I noticed a difference in my physique within a week of adding cardarine into my regimen. Today my gf told me I look really lean. She's been calling me fat (only 50% jokingly) for the past year.

 

[T-Bone]

All I can say is I noticed a difference in my physique within a week of adding cardarine into my regimen. Today my gf told me I look really lean. She's been calling me fat (only 50% jokingly) for the past year.

She is suppose to tell you you look good. That's what makes her a good girlfriend. I wouldn't judge anything within a week. You can look more lean or more bloated and fat depending on the time of day, what you eat, after exercise....So many variables...It could also be that you've been working harder in the gym since taking GW, thinking, "I don't want to waste this...". The results could be and probably are more from hard work and less if anything from the GW.

 

[BamBam0319]

She is suppose to tell you you look good. That's what makes her a good girlfriend.

True, BUT she also is the type to tell it how it is, and she was right. I have had extra body fat on me compared to when we met. Today was the first time I've heard her call me skinny in a long time lol

 

[T-Bone]

True, BUT she also is the type to tell it how it is, and she was right. I have had extra body fat on me compared to when we met. Today was the first time I've heard her call me skinny in a long time lol

Edited my post.

 

[BamBam0319]

She is suppose to tell you you look good. That's what makes her a good girlfriend. I wouldn't judge anything within a week. You can look more lean or more bloated and fat depending on the time of day, what you eat, after exercise....So many variables...It could also be that you've been working harder in the gym since taking GW, thinking, "I don't want to waste this...". The results could be and probably are more from hard work and less if anything from the GW.

That's fair, but I'm honestly pretty consistent with my intensity in the gym. Maybe it's not ALL due to the GW but I think it definitely is having an effect on me.
And I don't often say that about a supplement. Often I am suspicious of the effectiveness of something on my body personally. This is why I use creatine off and on because even when I am consistent with it I really don't notice much.

 

[mountainman33]

There is no such study.

http://www.aboutlawsuits.com/creatine-cancer-study-81020/

Here ya go....

 

[StanleyG]

GW , IMO, is absolute garbage even with cancer study aside. Ive used it with and without aicar and it didnt do a damn thing.
In fact on most forums where it isnt shilled so heavy like it is here it is pretty much accepted as useless for bodybuilders. Yes useless, in fact even on a forum where road cyclists are head over heels for endurance boosters they do not care for GW. Thats just is what it is so someone can chime in and say they love it and it did xyz for them all I am saying is this place is the exception not the norm when it comes to GW and one can only wonder why that is. Or one can look at GW and call it for what it is, a perhaps well marketed (if you call such tactics good marketing) yet very ineffective supplement.

 

[yates84]

GW , IMO, is absolute garbage even with cancer study aside. Ive used it with and without aicar and it didnt do a damn thing.
In fact on most forums where it isnt shilled so heavy like it is here it is pretty much accepted as useless for bodybuilders. Yes useless, in fact even on a forum where road cyclists are head over heels for endurance boosters they do not care for GW. Thats just is what it is so someone can chime in and say they love it and it did xyz for them all I am saying is this place is the exception not the norm when it comes to GW and one can only wonder why that is. Or one can look at GW and call it for what it is, a perhaps well marketed (if you call such tactics good marketing) yet very ineffective supplement.

Do you ever have anything positive to say or do you just stalk this forum to complain about the PEDs everyone else is using?

 

[Parad0x]

Breathing causes cancer, but I wouldn't recommend not doing that

 

[The_Old_Guy]

Do you ever have anything positive to say or do you just stalk this forum to complain about the PEDs everyone else is using?

Stan's dropped some good knowledge on AM, for me anyway, and been helpful via PM. People give opinions (and anecdotal experience) on discussion boards - some will agree, and some will disagree. My .02

 

[yates84]

Stan's dropped some good knowledge here, for me anyway, and been helpful via PM. People give opinions (and anecdotal experience) on discussion boards - some will agree, and some will disagree. My .02

Yeah but disagree every post?

 

[uubiduu]

Nolva can also cause cancer btw.

 

[IronMind]

I wouldn't trust any retailer that sells GW. The fact that it caused cancer in animals is enough for a responsible retailer not to sell it.

 

[bighulksmash]

I wouldn't trust any retailer that sells GW. The fact that it caused cancer in animals is enough for a responsible retailer not to sell it.

Are you for real ? Are you hopping on the bs band wagon here ? Know your facts . Did you read the study ?
:bsflag:

 

[yates84]

Are you for real ? Are you hopping on the bs band wagon here ? Know your facts . Did you read the study ?
:bsflag:

Definitely a major facepalm

 

[uubiduu]

Why a facepalm?

 

[IronMind]

Are you for real ? Are you hopping on the bs band wagon here ? Know your facts . Did you read the study ?
:bsflag:

BS bandwagon? So, it's false that GW research was discontinued? Source?

 

[yates84]

BS bandwagon? So, it's false that GW research was discontinued? Source?

I think you need to catch up on some of the gw studies before you make such rediculous comments

 

[IronMind]

I think you need to catch up on some of the gw studies before you make such rediculous comments

I asked for a source. I'm posting my opinion on using something that was abandoned due to cancer causing effects in animals. If I am wrong, please provide proof so that I can edit my post and move along. Thanks!

 

[bighulksmash]

I asked for a source. I'm posting what I know so no one gets cancer. If I am wrong, please provide proof so that I can edit my post and move along. Thanks!

When i get off work ill find it . Until then realize that humans and mice are a different genetic material .