T-3 or Trimax
- 04-08-2005, 04:28 PM
- 04-08-2005, 04:57 PM
- 04-08-2005, 05:05 PM
Not exactly. It's a thyroid hormone metabolite.
04-08-2005, 05:33 PM
they are essentially the same thing, i wouldn't think one is more catabolic than the other. if you are worried about the catabolic nature then why not stack it with some AAS.
04-08-2005, 05:36 PM
I'll guess your right. Hmm gives me somthings to think about.
04-08-2005, 07:43 PM
i went with T3 for the simple fact that it's been used for alot longer than trimax and the effects are well-documented. i would expect both to be catabolic (T3 is, IME)
04-08-2005, 11:37 PM
04-09-2005, 10:02 AM
Uptake of triiodothyroacetic acid and its effect on thyrotropin secretion in cultured anterior pituitary cells
ME Everts, TJ Visser, EP Moerings, R Docter, H van Toor, AM Tempelaars, M de Jong, EP Krenning and G Hennemann
Department of Internal Medicine, Erasmus University Medical School, Rotterdam, The Netherlands.
The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release were compared. Cells isolated from adult male Wistar rats were cultured for 3 days in medium with 10% fetal calf serum. Uptake was measured at 37 C with [125I]Triac (100,000 cpm; 120 pM) or [125I]T3 (50,000 cpm; 50 pM) in medium with 0.5% BSA. In this medium, the ratio of the free fractions of Triac, T3, and T4 was 1:8:1. Exposure of cells to 100 nM TRH for 2 h stimulated TSH release by 80-110% (P < 0.001). Comparing total hormone levels (1 nM to 1 microM), Triac and T3 were equally effective in reducing this response, and both were 10-fold more effective than T4. The time course (15 min to 4 h) of [125I]Triac uptake was similar to that of [125I]T3, showing equilibrium after 1 h. Unlabeled Triac (1 microM) reduced the uptake of [125I]Triac and [125I]T3 at all time intervals. Expressed per pM free hormone, the cellular and nuclear uptake of [125I]Triac were twice those of [125I]T3. The 15-min uptake of [125I]Triac was reduced by incubation with 10 nM unlabeled Triac (35%; P < 0.001). Maximum inhibition (56%; P < 0.001) was found with 10 microM Triac. A similar effect was seen with 10 microM T3, T4, or 3,3',5,5'-tetraiodothyroacetic acid. Preincubation (30 min) and incubation (15 min) with 10 microM oligomycin reduced the cellular ATP content by 51% (P < 0.001), [125I]T3 uptake by 77% (P < 0.001), and [125I]Triac uptake by only 25% (P < 0.001). The temperature dependence of [125I]Triac and [125I]T3 uptake was the same. Preincubation and incubation with 10 microM monensin (reduces the Na+ gradient) or 10 microM monodansylcadaverine (inhibits receptor-mediated endocytosis) reduced 15-min [125I] Triac uptake by 15% (P < 0.005) and 19% (P < 0.005), respectively. The data show that 1) Triac, on the basis of the free hormone concentration, is more potent than T3 or T4 in suppressing TSH secretion; and 2) the rapid uptake of [125I]Triac by the anterior pituitary occurs by a carrier-mediated mechanism that is only partially dependent on ATP or the Na+ gradient.
for full text
04-09-2005, 03:49 PM
so, conclusions are:Originally Posted by Syr
1) T3 and triac produce equal TSH secretion
2) triac's uptake is greater than T3 (not really important considering the first point)
2) triac suppresses TSH more than anything else (not good)
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