Letrozole

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    Letrozole


    Hi guys,

    I used letrozole and I seem to have the tapering up and down factor down pretty good. However whenever I taper down. The next week my gynomastic symptoms some what return. It looks slightly better than before however when Im in the middle of the treatment my chest looks great after the first few days! How do I keep the benefits after my letro treatment is complete?

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    Quote Originally Posted by DrolFIGHTER View Post
    Hi guys,

    I used letrozole and I seem to have the tapering up and down factor down pretty good. However whenever I taper down. The next week my gynomastic symptoms some what return. It looks slightly better than before however when Im in the middle of the treatment my chest looks great after the first few days! How do I keep the benefits after my letro treatment is complete?
    The only way to completely remove gyno is through surgery. Period.
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    I have not used it as of yet but I plan on it. Formastane is supposed to down regulate the estrogen receptors. Not sure if it would help with existing gyno symptoms.
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    You need to run it for a longer period of time. Also tapering into exemestane is ideal. Letro deactivates aromatase, but when you cease using it the aromatase reactivates after a time. Exemestane permanently deactivates aromatase.
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    Throw some 20mg nolva ED in when you start tappering down the letro.
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    Quote Originally Posted by BigBlackGuy View Post
    You need to run it for a longer period of time. Also tapering into exemestane is ideal. Letro deactivates aromatase, but when you cease using it the aromatase reactivates after a time. Exemestane permanently deactivates aromatase.
    what BBG said. Letro crushes your E2 so when you come off you will get estro rebound. your best bet is to run nolva or clomid when you come off letro till your E2 levels stabilizes..
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    Quote Originally Posted by gregg1494 View Post
    Throw some 20mg nolva ED in when you start tappering down the letro.
    I wouldn't do it this way. When you come off the nolva your E2 will still be elevated.
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    Quote Originally Posted by BigBlackGuy View Post
    You need to run it for a longer period of time. Also tapering into exemestane is ideal. Letro deactivates aromatase, but when you cease using it the aromatase reactivates after a time. Exemestane permanently deactivates aromatase.
    If the aromatase function is shut down you better hope hes on trt.
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    Quote Originally Posted by pyrobatt View Post
    If the aromatase function is shut down you better hope hes on trt.
    Aromasin deactivates aromatase enzyme that is in the body, it doesn't stop the body from producing aromatase. Aromasin just stops a spike from occurring after you're done using it, unlike letro, which leaves all that aromatase in the body. After you finish letro, the aromatase becomes active again and means a lot more estrogen being created from testosterone.
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    Quote Originally Posted by pyrobatt View Post
    If the aromatase function is shut down you better hope hes on trt.
    aromasin (exemestane) only inhibits the receptors for as long as they are there. Eventually new receptors will be made and old ones discarded, thus ridding you of the aromasin. Plus aromasin is relatively mild in terms of killing E2, in my opinion. But what do I know :-)
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    Quote Originally Posted by DrolFIGHTER View Post
    Hi guys,

    I used letrozole and I seem to have the tapering up and down factor down pretty good. However whenever I taper down. The next week my gynomastic symptoms some what return. It looks slightly better than before however when Im in the middle of the treatment my chest looks great after the first few days! How do I keep the benefits after my letro treatment is complete?
    By using nolva with it and after you stop the letro
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    Quote Originally Posted by BigBlackGuy View Post

    I wouldn't do it this way. When you come off the nolva your E2 will still be elevated.
    No it won't
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    Quote Originally Posted by BigBlackGuy View Post

    Aromasin deactivates aromatase enzyme that is in the body, it doesn't stop the body from producing aromatase. Aromasin just stops a spike from occurring after you're done using it, unlike letro, which leaves all that aromatase in the body. After you finish letro, the aromatase becomes active again and means a lot more estrogen being created from testosterone.
    This isn't true.

    Yes, aromasin is a suicide inhibitor, but rebound is possible, as well as even more hormonal disruption.

    Letro and raloxifene are the way to go.

    But letro an nolva work well too.
    Id toss in some inhibit p as well
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    Quote Originally Posted by jbryand101b View Post
    This isn't true.

    Yes, aromasin is a suicide inhibitor, but rebound is possible, as well as even more hormonal disruption.

    Letro and raloxifene are the way to go.

    But letro an nolva work well too.
    Id toss in some inhibit p as well
    What would dosing of letro and raloxifene look like?
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    So should I run Nolva during treatment and after taping or should I run Exemestane? How should I Dose? I'm currently cycling right now and using Letro as Estrogen protection. It's helping avoiding the acne and avoiding the puffy nips which is primarly my main concern. Currently running Mechabol, Epistane, and SHRED. Don't judge me please it's my bod, just stay on topic. By the way thanks alot guys for all your help. I'm going to look into the Exemestane and Nolvadex right now. It's not a bad case of Gynomastia. Just the Pseudo juice affects...
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    In my opinion, I wouldn't touch Letro without a followup of Aromasin.
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    Quote Originally Posted by thegodfather View Post
    In my opinion, I wouldn't touch Letro without a followup of Aromasin.
    Or If aromasin did nothing for you give Nolva solo a go.
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    An ai followed up with another ai makes no sense.
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    Quote Originally Posted by jbryand101b View Post
    An ai followed up with another ai makes no sense.
    A non responder to aromasin may respond to Nolva. I'm not totally bought into using the same thing a second time if it didn't work the first go around but I wouldn't jump to letrozole till I tried both Nolva and aromasin.
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    So I should try to run 20mg of Nolva during cycle and for pct?
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    I don't know what SHRED is but tamoxifen (nolvadex) while on (and while off) stops the e from binding at the receptor (in breast tissue).
    I had a slight case of gyno (puffy nips, soreness) and was prescribed 20mg tamoxifen ED. 3 weeks and no more symptoms. I continue to take tamoxifen and have not had any symptoms since.
    Tamoxifen will not decrease the level of e in your body, that's the job of an inhibitor. SERMs and AIs serve different functions. Hope this helped.
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    Quote Originally Posted by iparatroop View Post
    I don't know what SHRED is but tamoxifen (nolvadex) while on (and while off) stops the e from binding at the receptor (in breast tissue).
    I had a slight case of gyno (puffy nips, soreness) and was prescribed 20mg tamoxifen ED. 3 weeks and no more symptoms. I continue to take tamoxifen and have not had any symptoms since.
    Tamoxifen will not decrease the level of e in your body, that's the job of an inhibitor. SERMs and AIs serve different functions. Hope this helped.
    Odd fact most ignore is that a SERM will actually increase the amount of estrogen you have which is why I always taper an AI post SERM or did until I got a script..
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    Quote Originally Posted by harbonah View Post
    Odd fact most ignore is that a SERM will actually increase the amount of estrogen you have which is why I always taper an AI post SERM or did until I got a script..
    Just for clarity, is it that the SERM "increases" estrogen, or is it that since the estrogen is unable to bind to the "busy" receptor that it would make it seem as if there is more estrogen in the body?
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    Quote Originally Posted by iparatroop View Post
    Just for clarity, is it that the SERM "increases" estrogen, or is it that since the estrogen is unable to bind to the "busy" receptor that it would make it seem as if there is more estrogen in the body?
    Correct its the change in binding from what I have read.
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    Quote Originally Posted by harbonah View Post
    Correct its the change in binding from what I have read.
    Makes perfect sense. That which is not bound is free to roam.
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    Oi. Craziness up in here. Makes me tired.
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    Quote Originally Posted by jbryand101b View Post
    Oi. Craziness up in here. Makes me tired.
    Are we way off base?
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    Quote Originally Posted by iparatroop View Post
    Are we way off base?
    Honestly I could be wrong on the mechanism that is causing the increase but I have a few studies saved that point to it happening.

    Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men.
    http://www.ncbi.nlm.nih.gov/m/pubmed/640052/


    Changes in serum estrogen levels in women during tamoxifen therapy.
    http://www.ncbi.nlm.nih.gov/m/pubmed/9168075/


    And given the typos I'm putting down the tablet for bed time...to late for me.
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    I don't know why letro gets such a bad wrap. It works amazing, strong as ****, helps with gyno greatly. Sides an can be intense but nothing to crazy
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    Quote Originally Posted by dubfungus View Post
    I don't know why letro gets such a bad wrap. It works amazing, strong as ****, helps with gyno greatly. Sides an can be intense but nothing to crazy
    Meh I never seem to get sides from letro myself. Blah can't type sleep time :thumbdown::thumbdown:
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    When I get s chance to get to my computer, I'll type some stuff.

    No way I'm gona try explaining on my phone. Lol
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    Quote Originally Posted by jbryand101b View Post
    When I get s chance to get to my computer, I'll type some stuff.

    No way I'm gona try explaining on my phone. Lol
    Do you have more on this? Not calling you out I'm just interested and always up for new info.
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    Yea, but my wife has been using my computer to watch the amazing race, every night. So all my posting has been on my phone.
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    Quote Originally Posted by jbryand101b View Post
    Yea, but my wife has been using my computer to watch the amazing race, every night. So all my posting has been on my phone.
    Lol I can sympathize I'm stuck watching vampire diaries right now for the same reason..
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    Quote Originally Posted by harbonah View Post

    Lol I can sympathize I'm stuck watching vampire diaries right now for the same reason..
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    Quote Originally Posted by pyrobatt View Post
    Survivor here....
    Oh man do I feel for you! My ex wife used to make me watch that show...and then buy the season on DVD to re-watch it? Which I could never understand I was like WTF you know how it ends you know who wins how can this be fun to watch?
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