11-26-2012 11:10 PM
Started my cycle today which will consist of:
5 pumps/5/5/5/5/5 Transaderm
1-carboxy-2-amino- 3-pyrobenzol (3,4 diol)
Cycle Support 2 scoops a day
Clomid at 50/50/25/25
Daa at 3/3/3/3/3/3
Erase at 0/0/3/3/2/1
Pre-workout Jack3D original now (Flashover up next)
6'4 225lbs ~14% weighed in this morning
Thoughts or suggestions on anything? Not my first cycle. Nor first time with trenazone. Excited for some good results. Will be eating everything in sight as well.
11-26-2012 11:26 PM
looks awsome. but what is 1-carboxy-2-amino- 3-pyrobenzol (3,4 diol)???
11-26-2012 11:36 PM
Bulk 1-carboxy-2-amino-3-pyrobenzol(3,4 diol)
Bulk 1-carboxy-2-amino-3-pyrobenzol(3,4 diol) [hereafter "Bulk 1-carboxy"] is a powerful and highly effective growth-hormone and testosterone agonist. Benefitting from USPowders' unique herbal extraction technology and unmatched value-for-money, Bulk 1-carboxy was specifically designed to deliver the following benefits, amongst others:
Dramatic boost in endogenous natural growth-hormone production
Pronounced stimulation of natural testosterone production
Potent prolactin inhibition
Significant and unmistakeable mind-muscle connection (via elevated neuronal dopamine response)
Dramatic improvement in deep recuperative sleep architecture and post-exercise recovery
Markedly enhanced libido and sexual function
Powerful lipolytic action and muscle preservation.
Improvement in various metabolic markers
To understand how Bulk 1-carboxy elicits these results, it is useful to review the synthesis of dopamine and natural growth hormone.
A specific extract of Dolichos Pruriens L., Bulk 1-carboxy (itself closely related to L-DOPA) stimulates an increased production of endogenous dopamine, leading to downstream increases in the production of endogenous natural growth hormone via the dopaminergic-pituitary-GH axis.
As is well known, in healthy individuals, natural growth hormone (GH) secretion, as is also the case in general for hypothalamic and pituitary hormones, is tightly regulated by feedback and feed-forward loops. In particular, the hypothalamic agent growth-hormone releasing hormone (GHRH) stimulates the pituitary release of growth hormone. The pituitary release of GH is partly (negatively) regulated by another hypothalamic agent, somatostatin, also known as growth hormone-inhibiting hormone (GHIH). Supplementation with Bulk 1-carboxy leads to an increased synthesis of dopamine, and the hypothalamic action of dopamine leads to an inhibition of somatostatin, allowing GHRH to induce increased pituitary growth hormone secretion. So, Bulk 1-carboxy supports growth hormone secretion via enhanced L-DOPA synthesis and hypothalamic somatostatin inhibition. As somatostatin blunts growth hormone secretion via GHRH antagonism, the dopamine inhibition of somatostatin enhances the action of the dipeptide, growth hormone-releasing hormone (GHRH). This leads to an elevated release of natural growth hormone. Furthermore, dopamine acts as a prolactin inhibitor (prolactin is a pituitary hormone secreted by the acidophilic pituitary lactotropes). As it turns out, prolactin not only demonstrates a positive correlation with somatostatin, but also enjoys a negative correlation with testosterone (via inhibition of gonadotropins). As a consequence, Bulk 1-carboxy stimulates increased secretion of testosterone and growth hormone by suppressing the expression of somatostatin and prolactin.
Furthermore, increased production of dopamine directly stimulates increased secretion of gonadotropin-releasing hormone (GnRH) [also known as luteinizing hormone-releasing hormone (LHRH)], responsible for the production of testosterone, leading to the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH), both gonadotropins secreted by the pituitary gland. In particular, LH and FSH, in turn, stimulate the Leydig cells (via LH) and the Sertolli cells (via FSH) of the male gonads (testicles) to amplify the production of androgens, including testosterone (a process also called steroidogenesis) and semen (a process also called spermatogenesis) respectively. FSH acts, not only by sensitizing the testes to the effects of LH (via the response of LH to luteinizing-hormone releasing hormone (LHRH)), but also by increasing the number of testicular LH receptors, ultimately leading to a greater endogenous production of testosterone.
As has already been established, Bulk 1-carboxy elicits elevated growth-hormone production via a dopaminergic pathway. Without Bulk 1-carboxy, dopamine is derived from the synthesis of tyrosine, so dopamine is a tyrosine-derived neurotransmitter. Recall that tyrosine not used up for energy production or incorporated into proteins, is converted into catecholamine neurotransmitters (dopamine, norepinephrine, and epinephrine). Catecholamine synthesis occurs in neurons and the adrenal medullary cells. When tyrosine is transported into these neurons and cells, it is converted into DOPA (3,4-dihydrophenylalanine) via the enzymatic action of tyrosine hydroxylase and the co-factor tetrahydrobiopterin. An enzyme, DOPA decarboxylase then converts DOPA to dopamine within the substantia nigra and some other parts of the brain. Within the adrenal medulla, however, dopamine is converted to norepinephrine via the action of the enzyme, dopamine ?-hydroxylase. Finally, another enzyme, phenylethanolamine N-methyltransferase, converts norepinephrine to epinephrine.
Why is this tyrosine angle relevant? Simple! DOPA is a substrate for not just dopamine, but also for norepinephrine and epinephrine. In other words, not all L-DOPA (or even tyrosine) we consume ends up as dopamine in the substantia nigra. So, to ensure a sufficient amount of dopamine is ultimately available for stimulation of GH production, a compound such as Bulk 1-carboxy assumes critical importance. To put this into perspective, only a small fraction of the L-DOPA taken orally ever reaches the brain, as blood enzymes such as amino acid decarboxylases (AADCs) metabolize most of the levodopa before it reaches the brain, unless it is taken with appropriate dopamine agonists, enzyme inhibitors or transport vehicles that inhibit L-DOPA decarboxylation in the bloodstream or in tissues outside the brain, ensuring an increase in the amount of L-DOPA that finally reaches the brain for enzymatic conversion to dopamine. To ensure a greater amount of the consumed L-DOPA survives decarboxylation, the concomitant use of dopamine agonists, dopa decarboxylase inhibitors, catechol-o-methyltransferase (COMT) inhibitors, acetylcholine inhibitors, or neuroprotective agents, may be relevant. As it turns out, however, Bulk 1-carboxy is a bioavailable compound that is not only closely related to L-DOPA, but is also able to inhibit L-DOPA degradation in extra-cerebral cells, promote its passage through the blood brain barrier, and stimulate the pronounced synthesis of dopamine in the brain, leading to elevated secretions of endogenous growth hormone.
So, overall, Bulk 1-carboxy, a bioavailable natural L-DOPA, acting via the potent growth-hormone agonist, dopamine, delivers pronounced GH-stimulating effects leading to inhibition of prolactin secretion from pituitary lactotropes and the associated improvement in libido and sexual response; an enhanced mind-muscle connection via an elevated neuronal dopamine response; the stimulation of natural testosterone production; promotion of deep recuperative sleep and shortened post-exercise recovery patterns; improvement in lipolytic and antic-catabolic processes; the onset of superior repair of cellular damage; as well as improvements in skin aesthetics.
Good write up about the product from nutraplanet. Another libido helper to go with the Transaderm. Deca dick hits hard with tren for me ha
11-27-2012 09:42 AM
11-28-2012 07:41 PM
11-30-2012 08:12 PM
Looks great man! I'd throw in some antaeus labs aegis just to cover bases with the havoc, but it's probably not needed.
Keep us updated, I'll keep tabs on this thread!
Similar Forum Threads
By bigred6347 in forum Anabolics
Last Post: 10-14-2012, 08:29 AM
By wallkilllax35 in forum Anabolics
Last Post: 07-14-2012, 10:34 PM
By pigpen75 in forum Anabolics
Last Post: 03-10-2012, 01:07 PM
By trae1170 in forum Cycle Info
Last Post: 03-06-2012, 01:18 PM
By pigpen75 in forum Anabolics
Last Post: 01-27-2012, 11:48 PM