Orals: single dosing vs. spreadout

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  1. Orals: single dosing vs. spreadout


    Wanted to start a post to get some definitive (or closest to it), intelligent opinions/perspectives on the concept of single dosing orals in a day versus spreading the doses out. I've read sensible opinions on both sides.


  2. What's the half life of the compound in question? Are you looking for stable levels or a spike? Are there certain side effects (positive/negative) that make dosing certain times of the day beneficial or less hindering? And more. Too vague of a question in my opinion. Needs clarification of what the oral is and what goals are.
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  3. my sides are way worse with a single dose

  4. Quote Originally Posted by bpmartyr View Post
    What's the half life of the compound in question? Are you looking for stable levels or a spike? Are there certain side effects (positive/negative) that make dosing certain times of the day beneficial or less hindering? And more. Too vague of a question in my opinion. Needs clarification of what the oral is and what goals are.
    this^^^^

  5. Quote Originally Posted by fightclub2012 View Post
    this^^^^
    Jesus Christ guys. The question is simple. i'm not askin' about one particular compound. i've read opinions on both sides of this argument; no matter what orals are in question. Yes, the question is meant to be vague and simple--not specific to a certain anabolic. Some people say take all your orals at once which lessens testicular shutdown and some say to take throughout the day based on the half-life. Just wanted to get a full thread devoted to this subject to see what seems best.

  6. it depends on the compounds half life and if you can handle the sides, you want a definitive answer , you really need to be more specific. i.e lets say your doing SD at 20mgs a day , imo is take one(10mgs)in the moring and one about (10mgs)8-10hrs later , if its "on" a work out day id take my second dose about an hour before my session, if you train in the am id take about an hour that session. 8-10hrs later my second dose.
    What ph are you interested in? Every compound is different.

  7. For example: 1AD made me very sleepy so I took it before bed. MDHT gave me a nice psyche boost shortly after taking so I took pre workout.

    If your wondering more about suppression, again depends on the compound but anything worth taking is going to shut you down regardless.

  8. thx for replies. not referring to any compounds specifically. Duchaine, Llewelyn, and a member of this board share the commonality of dosing your orals once per day versus spread out. the opinions of these guys did not concern half-lives of compounds--just simply to dose orals all at the same time each day. their reasoning was to achieve the greatest peak blood levels and they also suggested it would reduce suppression. Again, they were NOT concerned with different compounds, whether it be D-bols, SD, winny, whatever--just pop em all at once, once per day. Just made me stop n think since 90% of folks say to pop based on half-life.

  9. Do they also suggest dosing test enanthate monthly to get spikes? lol

    Typically you want anabolic compounds at as close to constant concentration as feasible.

    Again, depends on the compound, but for what it sounds like you're looking for the answer would be: take things like Superdrol throughout the day; taking it all at one time will shut you down just as much as staggering.

    If you are going to waste any time and money on these orals, IMHO, you just just run them along with a nice testosterone cycle and worry about suppression after your carefully prepared PCT is finished. If it's worth doing it's worth doing right a wise man one told me, a thousand times.

  10. Quote Originally Posted by bpmartyr View Post
    Do they also suggest dosing test enanthate monthly to get spikes? lol

    Typically you want anabolic compounds at as close to constant concentration as feasible.

    Again, depends on the compound, but for what it sounds like you're looking for the answer would be: take things like Superdrol throughout the day; taking it all at one time will shut you down just as much as staggering.

    If you are going to waste any time and money on these orals, IMHO, you just just run them along with a nice testosterone cycle and worry about suppression after your carefully prepared PCT is finished. If it's worth doing it's worth doing right a wise man one told me, a thousand times.
    beating my head against a wall...........nevermind
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  11. Quote Originally Posted by bpmartyr View Post
    Typically you want anabolic compounds at as close to constant concentration as feasible.
    If I'm looking at this too simplistically, someone chime in.

    Each substance has a 1/2 life in the body. This is the time it takes for the concentration of the substance to decrease by 1/2. Thus, the higher the concentration, the faster the body is metabolizing the compound. By shooting for a more steady concentration, you are essentially maximizing the concentration over time (the area under the curve if you plotted concentration vs. time).

    Maybe there is a reason for maximizing blood concentration, but you would also be maximizing the rate your body is getting rid of the compound (unless it's rate limited for some reason).

  12. Quote Originally Posted by malcolm777b View Post
    If I'm looking at this too simplistically, someone chime in.

    Each substance has a 1/2 life in the body. This is the time it takes for the concentration of the substance to decrease by 1/2. Thus, the higher the concentration, the faster the body is metabolizing the compound. By shooting for a more steady concentration, you are essentially maximizing the concentration over time (the area under the curve if you plotted concentration vs. time).

    Maybe there is a reason for maximizing blood concentration, but you would also be maximizing the rate your body is getting rid of the compound (unless it's rate limited for some reason).
    yeah, i think that's basically what the people, on the side of taking all your pills at once, are making. thx for that suggestion.

  13. Quote Originally Posted by lilzekester View Post
    yeah, i think that's basically what the people, on the side of taking all your pills at once, are making. thx for that suggestion.
    Actually, I think you said that backwards, unless you're referring to my statement, "maybe there is a reason for maximizing blood concentration".

    There could definitely be a reason, ie. receptor binding being increased by increased blood concentration, but now you introduce variables such as binding affinity, and that is compound specific. Just so you know, I'm just postulating at this point.

  14. Quote Originally Posted by malcolm777b View Post
    Actually, I think you said that backwards, unless you're referring to my statement, "maybe there is a reason for maximizing blood concentration".

    There could definitely be a reason, ie. receptor binding being increased by increased blood concentration, but now you introduce variables such as binding affinity, and that is compound specific. Just so you know, I'm just postulating at this point.
    ya, just wanted to get some dialogue goin about this topic. just interested to see what people think.

  15. Quote Originally Posted by lilzekester View Post
    Wanted to start a post to get some definitive (or closest to it), intelligent opinions/perspectives on the concept of single dosing orals in a day versus spreading the doses out. I've read sensible opinions on both sides.
    I think it is better to spread the dose so you get steady levels of "X" compound... also you need to know whats the half life of the compound, and then based on that look at the dose to determine how long it will stay in your system and therefore still being optimal... the problem with single doses is that of course it should be dosed high, all at once, and seeing that orals are fast acting it can cause more stress... JMO
  16. Never enough
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    Quote Originally Posted by lilzekester View Post
    Jesus Christ guys. The question is simple. i'm not askin' about one particular compound. i've read opinions on both sides of this argument; no matter what orals are in question. Yes, the question is meant to be vague and simple--not specific to a certain anabolic. Some people say take all your orals at once which lessens testicular shutdown and some say to take throughout the day based on the half-life. Just wanted to get a full thread devoted to this subject to see what seems best.
    the vague and simple answer is "it depends"
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  17. Never enough
    EasyEJL's Avatar

    Quote Originally Posted by bpmartyr View Post
    Do they also suggest dosing test enanthate monthly to get spikes? lol

    Typically you want anabolic compounds at as close to constant concentration as feasible.

    Again, depends on the compound, but for what it sounds like you're looking for the answer would be: take things like Superdrol throughout the day; taking it all at one time will shut you down just as much as staggering.

    If you are going to waste any time and money on these orals, IMHO, you just just run them along with a nice testosterone cycle and worry about suppression after your carefully prepared PCT is finished. If it's worth doing it's worth doing right a wise man one told me, a thousand times.
    overall I agree, but so far as I've seen, the primary benefit to trying to keep a relatively constant level is that once you are shut down a more steady overall androgen level leaves you feeling better. But if you are running something like testosterone in the background that keeps at a more or less constant level of androgens (at least above baseline normal levels) I think dosing orals all at once is better.
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  18. You may be right. May also depend on the compound as well. Do I want a continuous steady level to keep promoting growth or a peak concentration near workouts to promote strength or aggression etc. /shrug

  19. It doesn't matter, just do whatever you want. Making a bigger deal out of this than it has to be.
    Try dosing a cycle each way, then decide what you like better.

    Simple.

  20. I agree with jbryand.
    and we all respond differently

  21. Question then what is the half life of Hdrol I been thinking of doing split doses on my current run but worried about insomnia if I take second dose to late in day
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  22. half life for hdrol is about 12hrs.

  23. A low dose first thing in the morning could help with suppression. It would need to be fairly low and the cycle should be kept short.

    If already on cycle, a single dose of another compound pre-workout may make sense (stano or ment)

    Transdermals are pretty cool in that a single morning dose has a built in time release.

    Otherwise, for most "normal" cycles I'd take the compound over 2 or 3 three doses.
  24. Unbreakable
    David Dunn's Avatar

    Quote Originally Posted by lilzekester View Post
    beating my head against a wall...........nevermind
    Sounds like the kettle calling the pot black to me.

    It does matter for reasons beyond half life and suppression.

    Some orals trigger accute hypertension, body sweats, rapid heart rate, aggression and or insomnia.

    Additionally, if you would like more 'discussion" on the topic quit becoming so irritated when people don't reply the way you want them to. They too are entitled to share their opinion...as you have done yours.
    Life is a terminal condition.

  25. Quote Originally Posted by jbryand101b View Post
    It doesn't matter, just do whatever you want. Making a bigger deal out of this than it has to be.
    Try dosing a cycle each way, then decide what you like better.

    Simple.
    Hey Jbry, would it be harder on your liver by processing all the pills at once?

  26. Quote Originally Posted by David Dunn View Post
    Sounds like the kettle calling the pot black to me.

    It does matter for reasons beyond half life and suppression.

    Some orals trigger accute hypertension, body sweats, rapid heart rate, aggression and or insomnia.

    Additionally, if you would like more 'discussion" on the topic quit becoming so irritated when people don't reply the way you want them to. They too are entitled to share their opinion...as you have done yours.
    The point of this topic was to start a dialogue. I did not ask for help or advice for anything i am personally doing. That dude kept responding with questions about my goals, and what particular compounds i was taking, etc. He was missing the point of my post. I started this topic because of imformation i've read going against the common practice of all day dosing. Just getting more opinions for topic's sake--not my sake.

  27. Quote Originally Posted by David Dunn View Post
    Sounds like the kettle calling the pot black to me.

    It does matter for reasons beyond half life and suppression.

    Some orals trigger accute hypertension, body sweats, rapid heart rate, aggression and or insomnia.

    Additionally, if you would like more 'discussion" on the topic quit becoming so irritated when people don't reply the way you want them to. They too are entitled to share their opinion...as you have done yours.
    "Additionally", i have not shared any of my opinions.
  28. Never enough
    EasyEJL's Avatar

    Quote Originally Posted by lilzekester View Post
    Hey Jbry, would it be harder on your liver by processing all the pills at once?
    it may, but the flipside is that your liver would also start clearing sooner, instead of staying stressed all day, even if stressed less per hour.
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  29. Unbreakable
    David Dunn's Avatar

    Quote Originally Posted by lilzekester View Post
    "Additionally", i have not shared any of my opinions.
    Are you done, or is there more?
    Life is a terminal condition.

  30. i get more sides and a even little more emotional. Ive done both and i will not go back to one a day dosing. hope that helps buddy
  

  
 

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