On my current cycle I have ran into gyno problems twice, the first time I was running just 600mg/week of test and 125mg eod of tren. I started taking nolvadex at 75mg/day for around 15 days, basically till I ran out of the one bottle I had, I was also taking .5mg eod of arimidex. Those two things didnt do jack to the lumps and it was actually slowly growing while on all that nolva and a-dex. So I went down to gnc, picked up some vitex and vitamin b6, took 3g of vitex a day and 500mg of vitamin b6 a day, and after 3 days it was completely gone. I believe that time was progesterone related for sure. The other time I had gyno pop up is when I upped my test dose to 900mg/week, just all of the sudden the lumps popped up, I was still taking vitex and b6 and upped the dose to 5g of vitex and 700mg of b6, still didnt do anything and continued to get worse over the next couple days. Then I took 100mg just one night of nolva and then the first day took 1mg adex, then 2 days after that .5mg each day, then after that just sticking with .5mg eod, and the lump is gone and and under control. I believe that flare up was mainly from too much estrogen. Im not doubting the study that says nolva works just fine, just wanted to add in my experience where nolva/adex didnt do anything and when I threw in a $5 bottle of vit b6 and a $5 bottle of vitex the problems were fixed in a snap where I believed they were caused by progesterone. Draw your own conclusions from that.