Spread them out. You will only be able to absorb so much at a time. Also, in particular space the 1ad and 4ad apart the most.
Both 1ad and 4ad use the same enzymes to convert to their anabolic hormones. 1ad is the more powerful one and the one you want to target the most. So dosing them apart will help prevent the 4ad from stealing some of 1ad's thunder so to speak.
Personally I feel that spreading them out evenly throughout the day is optimal, but is by no means a requirement or mean they won't work if done that way. I just like to keep even levels going as much as possible and try to prevent high peaks with following low troughs of the hormones in the body. Though that means you need to carry them around with you and dose more often which can understandably be a hassle.