First Documented Case of AS induce Toxic Hepatitis

[YellowJacket]

Androgenic/Anabolic steroid-induced toxic hepatitis.
Stimac D, Miliæ S, Dintinjana RD, Kovac D, Ristiæ S
J Clin Gastroenterol 2002 Oct; 35:350-2
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Affiliation
Division of Gastroenterology, Department of Internal Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia. davor.stimac@ri.hinet.hr
Abstract
Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice in just a small number of recipients. We present a 26-year-old male bodybuilder who self-administered high doses of androgenic/anabolic steroids that induced liver damage. One month before admission to the hospital, he used testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), and methylandrostenediol (30 mg/d by mouth, for 5 weeks).On admission, his bilirubin level was 470 micromol/L (direct, 360 micromol/L), his aspartate aminotransferase (AST) level was 5,870 IU/L, his alanine aminotransferase (ALT) level was 10,580 IU/L, his alkaline phosphatase (ALP) level was 152 IU/L, his gamma-glutamyl-transpeptidase level was 140 IU/L, his albumin level was 27.6 g/L, and his prothrombin time was 29%. During the patient's prolonged hospitalization, multiple tests and liver biopsy were performed, showing only toxic hepatic lesions. The patient was provided with supportive medical treatment. Clinical signs and laboratory findings improved substantially 12 weeks after the patient discontinued androgenic/anabolic steroids. The reasons for presenting this case were the much higher values of AST and ALT levels than reported in other studies, although the values of bilirubin and ALP were similar to those found in the literature. To our knowledge, it is the first case of toxic hepatitis induced by androgenic/anabolic steroids with predominantly hepatocellular necrosis instead of intrahepatic cholestasis.

[YellowJacket]

Now before everyone goes ape ****, lets clear up a few things. Look at the orals this guy was taking it and the lengt he ran them, thats what kicked his ass. Not to mention it listed no previously existing liver problems, not that there were any, but you certainly cant rule that out. And it also mentioned no liver protecting agents like ALA, milk thistle, Liv52 and listed nothing about the water intake. This guy beat himself up for lack of knowledge. This is why newbies shouldnt be using AAS.

[Matthew D]

Okay you just answered my questions.. Sorry but that is a great example of a dumbass that didn't think before he did something..

[Sir Foxx]

Ok, I can understand the toxicity of the orals he was taking, but he either had pre-existing conditions, or had done many, many cycles like this before. Hell, this is probably only one week's worth for a top5 pro.

[John Benz]

I have a good friend who has chronic hepatitus symptoms from liver damage due to too many d-bol cycles 10 years ago. AAS are not for children nor the uneducated.

[wojo]

so let me get this straight ,no d-bol only cycles?
damn proof positive u should have at least a complete blood panel run pre and post cycle,along with a physical...stupid people bred

[John Benz]

Originally posted by wojo
so let me get this straight ,no d-bol only cycles?
damn proof positive u should have at least a complete blood panel run pre and post cycle,along with a physical...stupid people bred

Of course they weren't d-bol only cycles, but he blames the d-bol for his liver problems. pjorstad, is that you?

[wojo]

c'mon benz it was a joke..ouch that one hurt

[Matthew D]

I am with you on the physical part wojo.. but again that goes in to the planning and research part of starting a cycle. Just wish would could find a way to remove the "stupid" gene from the genetic makeup of humans... but then again, it would be hard to find test pilots and other high risk career people.

[size]

that is not that high a dosage for orals or a long length of time. Study is to vague to really proove anything one way or another. Maybe the guy drank every night, took orals, and painkillers.

[MrTrap]

Originally posted by YellowJacket To our knowledge, it is the first case of toxic hepatitis induced by androgenic/anabolic steroids with predominantly hepatocellular necrosis instead of intrahepatic cholestasis. [/B]

That reads like it was the first case with that form (necrosis instead of cholestasis), not the first documented case overall.

Traps