Is there a method to convert 1,4 Andro to Boldenone base?
- 07-09-2004, 02:11 AM
Is there a method to convert 1,4 Andro to Boldenone base?
Is there a known method to convert 1,4-dione to boldenone base? Ive read of something using MnO2
I found this article, originally posted by crazy pete:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
sondheimer et al.
1g 4AD + 100mL chloroform + 10g MnO2 = test base 100% after 2 hours shaking at room temp
yield is 93% when crystalized with methanol and filtered on paper
MATERIALS: (check www.sciencelab.com i don't know if they are the cheapest, but they have everything)
hotplate with built in stirrer
chloroform (can be cheaper grade)
thermometer (-10 to 150 degrees celcius, its like $4)
activated MnO2 (if this cannot be found, make your own from potassium permanganate and manganese sulfate. also need ether if you do this step)
funnel (holds filter paper)
earlmeyer flask with vacuum tube out side for vacuum filtering
now that is alot of MnO2 and it can be done with less. too simple you say, well your right its not that easy. the MnO2 available commercially is not always active. but the authors gave a method of preparing MnO2 that is easy and the product is very active and can be put in a stoppered jar with no loss of activity (those guys would make great homebrewers)
HOW TO MAKE MnO2:
take concentrated aqueous potassium permanganate and add to a stirred aqueous manganese sulfate solution kept at 90 degrees celcius (need a hot plate that has stirrer built in) until a slight excess was present (pink coloration of the supernatant liquid). stir at 90 degrees celcius for 15 minutes. filter, wash well with hot water, then methanol and ether. dry at 120 to 130 degrees celcius to a constant weight. it can be kept for several months in a well stoppered bottle with no loss of activity.
how to get concentrated aqueous potassium permanganate: take distilled water and and add potassium permanganate until not more goes into solution (this is where a magnetic stirrer comes in handy). if you added too much, just add more water until all is in solution. duh!
how to get aqueous manganese sulfate: same idea as above.
i am looking for a source of activated manganes dioxide so that the above does not need to be performed. once we get the manganes dioxide, all we have to do is mix the 4AD, MnO2 and chloroform in the ratios above, basically add the 4AD to chloroform on the magnetic stirrer and then add the MnO2 and leave it for 3 hours at room temp. add methanol to the solution and the test will crystalize and fall out of solution. filter and wash well with methanol. collect the filtrate and filter again on new filter paper and dry all the filter papers. if the filtrate still has crystals, filter with another paper. i would dry the first filter paper out well for a few days and weigh it. if its more than 80% yield, i wouldn't waste time trying to get the rest. if not, then take the filtrate and refilter to get rest of crystals. you kind of play it by ear. that's pretty much it.....oh yeah, don't forget to discard the powder properly as this is an experiment
it is possible that much less MnO2 can be used. this will mean that the reaction will have to sit longer maybe a day or two, i don't really know. this will have to be found out. i want to try this in the lab where i can measure the ultraviolet spectrum to determine how long the complete reaction takes with different amounts of MnO2 and chloroform so as to minimize cost.
why did i not do it step by step? well if you can't figure it out, then you probably shouldn't be doing it.
THIS SHOULD WORK JUST THE SAME FOR 19nor4diol to NANDROLONE
ba-doop, ba-doop, that's all folks
Anyone every tried it?
- 07-09-2004, 02:33 AM
Hmmm...isnt MnO2 the stuff in batteries? And can this be activated by boiling with dilute HCL (around 3%)?
07-10-2004, 01:04 AM
It's not the same, 4ad is an alcohol and can be oxidized in many ways. I would probably try NaMeO first, but MnO would be cheap and you could get the powder online w/out the battery extraction. If you didn't hault the reaction in time, you might get a lot of andro as a by product. What you want to do is tricky because 1,4-dione is a ketone and requires reduction. Very mild, selective reduction.Originally Posted by BigVrunga
07-10-2004, 07:36 PM
07-10-2004, 10:22 PM
To the best of my knowledge, there aren't any real-world selective reducing agents. When I say "real-world" I'm talking about borohydrides, catalytic reductions, or even lithium aluminum hydride since these are all reasonably ob˘ainable (LAH is pretty damn dangerous). There are a handful of well t˛aveled routes to testosterone from the dione. They widely range in difficulty and practicality, but one aspect all of these routes have in common is the ability to differentiate the 3 end from the 17 end... One scheme makes use of the special reactivity to ethylene glycols at the 3 end. The 3 keto is transformed into an ethylene glycol derivative (a protective group) while the C17 C=O remains essentially unchanged (or so they say). The next step is the sequential reduction and acylation of the C-17 carbon from ketone to alcohol to acetate ester. Like the glycol derivative on the C3 end, the acyl group serves to protect the hydroxyl on C-17 from the ensuing oxidation of C3 to C=O.. This is typically and traditionally done with Jones' reagent (Cromic acid), although an array of oxidants exist that will do this job better (starting with chlorox bleach)..
Interested in more? Buy my book
07-11-2004, 12:48 AM
Chromic oxidation is pretty harsh and you must know the kenetics and reaction time to terminate w/ a good yeild. You could always employ S. cerevisiae (yeast) to obtain about a ~70% yeild of the D-enatiomer. Also, although the 3-keto could be removed and later restored after reduction at the 17 position, the 3 position protection offered by an ethylene ketal group, after having prep'ed the 3-oxo, could give good yields.
Andy, you said you'd send me a special free autographed copy of your book!
07-11-2004, 01:43 AM
Ok Andy what is the title of this book and where can I get a copy?
So is there a way that the kitchen chemist could convert 1,4 to boldenone? Sounds like the process might be more complicated than its worth...
As far as the method quoted in my post -has anyone tried this with 4AD? And would it work to go from 19-NOR to nandralone?
07-11-2004, 07:48 AM
It is possible (practical) to go from 4-Diol ---> testosterone ---> testosterone ester ---> boldenone..Originally Posted by BigVrunga
Manganese dioxide accomplishes the first oxidation (tempormental--- side reactions are generally low, but sometimes yields are too.. no matter what, it will NOT oxidize C17 OH unless made first into a, b unsaturated alcohol.)
Selenium dioxide.. Sounds like the something your parents might make you take to GROW STRONG! Either that, or next week's stock up item at the local hippie food store.. As harmess as selenium dioxide sounds (sounds harmless to me if I didn't know anything about chemistry... nothing like, say, "peroxyphosphoric acid".. which (to me) is a more 'dangerous' sounding name... like sodium cyano borohydride!.) The name is misleading... Selenium dioxide doesn't have an RDA.... and, Well, you won't be ordering any selenium dioxide with your organic tiramisu b/c this stuff is pretty nasty...
Easy reaction though!
07-11-2004, 08:16 PM
07-12-2004, 12:40 AM
Here's one for you--
M-1,4ADoil + MnO2 in either chloroform or dichloromethane solution = Methandrostenalone
Would this work? If so the only concern might be what is largerst pore size that will filter off excess MnO2 after completion of the reaction; you'de definately want to get rid of as much manganese dioxide as possible before adminstration to lab animals.
07-12-2004, 01:24 AM
I don't think MnO2 is soluble in methylene chloride, I going to stick with the equalibrium reaction involving Sodium Methoxide in an abundance of ketone. I know it's selective.Originally Posted by growmore
07-12-2004, 02:15 PM
The idea comes from the same original reaction thats been posted at several boards. The original of coarse used 4AD for a final product of test but the principal is the same. From my understanding you would perposely use a solvent that only disolved the hormone and not the MnO2 so after the reaction (done on a magnetic stir) you could filter away the solid MnO2 particles. It's a fun idea, of coarse no one should ever try this where it may violate local laws... I'd be interested in hearing more about the the equilibrium reaction since I like to wrap my mind around this type of stuff once in a while. Also if you want a link to a thread at another board that goes more in depth on the subject shoot me a pm.
"1g 4AD + 100mL chloroform + 10g MnO2 = test base 100% after 2 hours shaking at room temp"
Originally Posted by DR.D
07-12-2004, 05:36 PM
"1g 4AD + 100mL chloroform + 10g MnO2 = test base 100% after 2 hours shaking at room temp"
Where is this from?
Is this true, or hack chemistry?
07-12-2004, 08:02 PM
I'm not a chemist so I can't tell you how realistic it is with a methyl derivative in use but it sounds reasonable. Supposedly it works alright with estered doil. Check this thread out over at Superior Muscle. Pay attention to posts from spidey.
Last edited by growmore; 07-12-2004 at 09:59 PM.
07-13-2004, 02:31 AM
It does mention in that thread that 1,4-diol can be converted to boldenone via dissolving in DCM and reacting with active MnO2...
07-14-2004, 02:51 AM
Definately would like to hear some input on this one from a chemist or someone who has at least a good grasp on chemical synthesis.
Hypothetically it seams the materials needed would be pretty easy to obtain; though none of the threads I've come across give any specifics on the best filterering material to use. Coffee filterers would probably be a poor idea for this but maybe a certain grade of lab filter paper or something similiar would suffice?
As far as solvent alternatives, from what I've gathered the process would not work in a methanol solution since the MnO2 would react with this leaving nothing behind for your desired reaction. Another thing that could speed the process is if there is something that would work to drop the final crystal hormone out of the chloro solution instead of waiting for evaporation (like is done with water drops in crystal tren.) it seams with H2O's poor soubility in chloroform that water would not work for this too well. Anyways this is just a little BUMP since I'm ejoying this thread.
07-14-2004, 07:18 AM
I have m questions about this.. It could work.. but how would you know if it did or not?Originally Posted by BigVrunga
07-15-2004, 03:13 AM
TLC? Test the melting point of the final product? Both methods are fairly simple and could be performed by the kitchen chemist. (with some decent equipment).
Im tempted to give this a try, although I dont really want to waste $100 worth of 1,4-diol and whatever the reactants cost.
07-15-2004, 03:52 AM
Buchner funnels are easy to find at online lab glass shops or ebay, and there's a wide variety of lab-grade filter available as well. It would be relatively easy to find the right filter for the fine MnO2 powder.Hypothetically it seams the materials needed would be pretty easy to obtain; though none of the threads I've come across give any specifics on the best filterering material to use. Coffee filterers would probably be a poor idea for this but maybe a certain grade of lab filter paper or something similiar would suffice?
One of the key things in this reaction is that the MnO2 has to be active, so finding a good source for active MnO2 would be necessary. I found a little blurb on the net that said MnO2 could be made active by boiling in dilute HCL, but I couldnt find any references to back it up.
As far as extraction - you could always distill off the chloroform rather than wait for evaporation. Once you arrive at a low enough volume where the chloroform/boldenone base solution is super saturated, it should cystalize as it cools. (let it cool slower for bigger crystals). The base could then be filtered off and purified via recrystallization.
Check this page out-its a great read on purification of a compound via recrystallization.
07-15-2004, 05:26 PM
As far as MnO2 being active, I've checked into this about a hundred times over at different sites on the web. From what I've gathered all that "active" MNo2 really is, is just a relatively pure MnO2. Since it seams this stuff can oxodize over time this is the reason you see different purity or "activity" levels in what's available. As far as I can tell, if you're buying a regeant or lab grade powder that is meant for oxidizing reactions than you should be pretty safe.
I may be wrong here, but as far as testing for purity of the final product, as long as I knew all of the MnO2 was filtered off I probably wouldn't be too concerned with this if I was going for a reaction with Methyl 1,4-- since the impuritiy would just be unconverted M-1,4add (although melting point might be worth it since it's so simple.) I like the link you gave for distillation but would heating to lower the solution volume be a concern for damaging your product?
Some lab grade MnO2 i've seen states 98% < 10 Micron-- this translates into very fine granules. I see all kinds of lab filtration paper for sale but not much about how small of particles it picks up. Glad to see we're making some progress here. Now who wants to take the plunge
Not a bad deal considering for the initial investment of about $150-$200 you could get what would be equal to about 800 5mg dbol tabs with even a poor conversion...
Last edited by growmore; 07-15-2004 at 06:01 PM.
07-16-2004, 03:21 AM
Good point. I couldnt find info on the melting point of boldenone, but the boiling point of DCM is only 40C (104F), that's not that high at all. Doubtful if it would degrade the product at that temperature.I like the link you gave for distillation but would heating to lower the solution volume be a concern for damaging your product?
Now you're talking methylated PH's here - will the MnO2 oxidation work for them as well?I may be wrong here, but as far as testing for purity of the final product, as long as I knew all of the MnO2 was filtered off I probably wouldn't be too concerned with this if I was going for a reaction with Methyl 1,4-- since the impuritiy would just be unconverted M-1,4add (although melting point might be worth it since it's so simple.) I like the link you gave for distillation but would heating to lower the solution volume be a concern for damaging your product?
So lets break down at the cost:
Say (hypothetically speaking) you want to go with boldenone base in a transdermal, with ~300mg absorbed per week. That's roughly 900mg of boldenone a week x 8 weeks = 7200mg. Might as well get 20g and take advantage of bulk pricing
20g 1,4 diol $50
100g MnO2 $40
Magnetic Stirrer ~$80 used on Ebay.
Can anyone with a bit more chemistry knowledge chime in and validate this method? Chemo?
Last edited by BigVrunga; 07-16-2004 at 08:56 AM.
07-16-2004, 07:11 PM
Don't forget the centrifuge!!
I'd say this is more of an essential than a stirplate!
Originally Posted by BigVrunga
07-16-2004, 08:27 PM
Why a centrifuge? The original method posted by spidey at SuperiorMuscle calls for stirring the mixture at room temp for 24 hours. You could use a glass stir rod if you wanted to stand over it for that long
07-16-2004, 08:41 PM
I still say use aluminum isopropoxide or sodium methylate w/ an oppen. equalib. reaction(cheap, easy and reliable), the MnO2 is old school sloppy, I/ve been a chemist for over 10yr's now, but nobody wants to listen! Bold MT ~ 165 deg
Last edited by DR.D; 07-16-2004 at 09:16 PM.
07-17-2004, 01:18 AM
thanks for the info - How are the aluminum isopropoxide or sodium methylate superior to MnO2 in this reaction, if they're accomplishing the same end result? (assuming the MnO2 oxidation of 1,4-diol has decent yields)
Im not a chemist - Ive done a lot of reading and some succesful acid/base extractions and recrystallization purifications, but I dont have any formal training. Could you please explain the "oppen. equalib. reaction" and outline the method that your talking about in your post?
07-17-2004, 02:01 AM
Check these out, then let me know if you want specifics. I've oxidized compounds successfully with this one, but not steroids. However, it was originally designed for steroids.Originally Posted by BigVrunga
I developed a hydroxide version of this too that shouldn't work but does w/ secondarys, although w/ lower yields
07-18-2004, 06:40 PM
There are hundreds of oxidation reagents, they each have their own time and place...Originally Posted by BigVrunga
The Oppenauer reaction is frequently employed from the oxidation toolbox. This oxidation (also MnO2 and others) have a degree of elegance since 'oxidation' ain't nearly as sexy as "selective oxidation." The Oppenaur type of oxidation would convert 5-ene- 3OL to a 4-ene 3-one (migration of the double bond occurs here). The reaction specs are more rigorous than MnO2 oxidation. Additionally, protection of the 17-ol once again becomes an issue.
07-18-2004, 06:46 PM
Why do you say this?Originally Posted by DR.D
Is there a better way for the selective oxidation of allylic alcohols?
07-18-2004, 06:54 PM
OK, look ... I've thought about this whole issue again and now I'm leaning to a simple chromic acid ox. Why not? It won't take secondary alc's past ketone and w/ a 17a-alkyl compound, you have required OH protection. You can milk the reaction and be sure that it's complete w/out side products.
07-18-2004, 06:57 PM
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