EvoMuse AlphaBurn

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  1. EvoMuse AlphaBurn


    Coming in TOMORROW, a Nutraplanet exclusive!

    You've been out of stock for far too long, my old friend....let's give the customers a hell of a deal to celebrate your return.
    Evolutionary Muse - Inspire to Evolve
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  2. Thumbs up


    Looking for n awesome deal! As you know, been waiting for months on this one.

    Quote Originally Posted by dsade View Post
    Coming in TOMORROW, a Nutraplanet exclusive!

    You've been out of stock for far too long, my old friend....let's give the customers a hell of a deal to celebrate your return.
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  3. Me too, brother...me too.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  4. Sweet!! Stackable with VL?
    Email me for free prodigy samples
    [email protected]
    www.pni-online.com

  5. Quote Originally Posted by howwedo107 View Post
    Sweet!! Stackable with VL?
    Stacks extremely well with Vanillean, given the central action of TRPV1 agonists and release of adrenergic catecholamines. Add some green tea, too, for a great stack.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
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  6. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    Very excited the time has finally come!
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
    EvoMuse Representative | [email protected] | Inspire to Evolve
  7. Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
  8. Re: EvoMuse AlphaBurn


    Picking this up for sure!!
    E-Pharm Rep... PM me with any questions or concerns

  9. You'll like what you see...should be around $14.99!!
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  10. Should it be up today?

    Quote Originally Posted by dsade View Post
    You'll like what you see...should be around $14.99!!

  11. Seeing as this wasn't up yesterday, will AlphaBurn be available within the next couple of days?

  12. Looks like there was a 1-day delivery delay because of weather. It will be delivered today
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  13. Any logging chances for this puppy?
    Email me for free prodigy samples
    [email protected]
    www.pni-online.com
  14. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    Quote Originally Posted by dsade View Post
    Looks like there was a 1-day delivery delay because of weather. It will be delivered today
    Stupid Flanders...I mean weather...

    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
    EvoMuse Representative | [email protected] | Inspire to Evolve

  15. Quote Originally Posted by RickyBDragon View Post
    Seeing as this wasn't up yesterday, will AlphaBurn be available within the next couple of days?
    Should be up anytime really. If it isn't then I can't see it going past tomorrow. I believe NP has it now.
    EvoMuse Products Rep

    PM me with any questions!

  16. I am confused, is Evo Muse part of the Southland brand? I thought you were with BPS now.

    If you managed to get legitimate rauwolscine and not yohimbine hcl you can colour me impressed.
    PEScience Representative
    http://pescience.com/insider
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  17. Quote Originally Posted by bdcc View Post
    I am confused, is Evo Muse part of the Southland brand? I thought you were with BPS now.

    If you managed to get legitimate rauwolscine and not yohimbine hcl you can colour me impressed.
    I've been using the same supplier since I introduced alpha yohimbine to the market back in 2003.

    I researched it and had it custom extracted because I have no tolerance for Yohimbine.

  18. Ladies and Gentlemen....a fantastic debut exclusive Nutraplanet price of $14.25 a bottle.

    http://www.nutraplanet.com/product/e...-capsules.html
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  19. Quote Originally Posted by dsade View Post
    Ladies and Gentlemen....a fantastic debut exclusive Nutraplanet price of $14.25 a bottle.

    http://www.nutraplanet.com/product/e...-capsules.html
    Wow! I want to throw this in with my VL log! That'd be a sick stack! And it's all non stim dsade doing it big bro if I wasn't such a stickler about shipping I'd pick up a bottle right now but ill have to wait until I put in my next order awesome stuff by the looks of it
    Email me for free prodigy samples
    [email protected]
    www.pni-online.com

  20. Uhlén S, Dambrova M, Näsman J, Schiöth HB, Gu Y, Wikberg-Matsson A, Wikberg JE BioMedical Centre, Department of Pharmaceutical Biosciences, Uppsala University, Sweden. [email protected]
    European Journal of Pharmacology [1998, 343(1):93-101]


    Type: Journal Article, Research Support, Non-U.S. Gov't, Comparative Study
    DOI: 10.1016/S0014-2999(97)01521-5
    Abstract Highlight Terms Gene Ontology(2) Genes/Proteins(3) Species(5) Chemicals(7)
    The Kd values of the recently introduced radioligand [3H]RS79948-197 ((8a R,12aS,13a-S)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-metho xy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]naphthyridine) were determined for the recombinant human and rat alpha2A-, alpha2B- and alpha2C- as well as guinea pig alpha2B- and alpha2c-adrenoceptors expressed in COS (CV-1 Origin, SV40) cells. In addition, the Kd values were also determined for [3H]RS79948-197 for the guinea pig spleen alpha2A-adrenoceptor and for pig alpha2A-, alpha2B- and alpha2C-adrenoceptors in membranes obtained from kidney and striatum. Available radioligands for alpha2-adrenoceptors, besides [3H]RS79948-197 are the tritiated forms of MK912 ((2S,12bS)1',3'-dimethylspiro(1,3,4,5',6,6',7, 12b-octa hydro-2H-benzo[b]furo[2,3-a]quinazoline)-2,4'-pyrimidin-2'-one), RX821002 (2-methoxy-idazoxan), rauwolscine and yohimbine. In the present article the binding constants of all these substances for the alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes in human, pig, rat and guinea pig are reviewed. In all species tested MK912 was alpha2C-selective, RX821002 showed a minor alpha2A-selectivity, whereas [3H]RS79948-197 was non-selective among the alpha2-adrenoceptor subtypes, showing high affinity for all three subtypes. Rauwolscine and yohimbine showed relatively low affinities for nmost of the alpha2-adrenoceptor subtypes investigated, the exception being rauwolscine having high affinity for the human and porcine alpha2C-adrenoceptors
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
  21. Re: EvoMuse AlphaBurn


    Great deal as always bro!!
    E-Pharm Rep... PM me with any questions or concerns

  22. http://ajpregu.physiology.org/content/283/2/R287.long

    Long read, but goes into the functionality of the Alpha 2 subtypes, their physiological functions and locational prevalence, and their function, while blockaded by Alpha-Yohimbine, on both acute (fight or flight) and basal epinephrine and norepinephrine levels.
    Evolutionary Muse - Inspire to Evolve
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    Neuroscience. 2002;109(4):819-26.
    Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice.

    Bücheler MM, Hadamek K, Hein L.
    Source

    Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.

    Abstract

    alpha(2)-Adrenergic receptors play an essential role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS. However, the role of each of the three highly homologous alpha(2)-adrenergic receptor subtypes (alpha(2A), alpha(2B), alpha(2C)) in this process has not been determined unequivocally. To address this question, the regulation of norepinephrine and dopamine release was studied in mice carrying deletions in the genes encoding the three alpha(2)-adrenergic receptor subtypes. Autoradiography and radioligand binding studies showed that alpha(2)-receptor density in alpha(2A)-deficient brains was decreased to 9 +/- 1% of the respective wild-type value, whereas alpha(2)-receptor levels were reduced to 83 +/- 4% in alpha(2C)-deficient mice. These results indicate that approximately 90% of mouse brain alpha(2)-receptors belong to the alpha(2A) subtype and 10% are alpha(2C)-receptors. In isolated brain cortex slices from wild-type mice a non-subtype-selective alpha(2)-receptor agonist inhibited release of [(3)H]norepinephrine by maximally 96%. Similarly, release of [(3)H]dopamine from isolated basal ganglion slices was inhibited by 76% by an alpha(2)-receptor agonist. In alpha(2A)-receptor-deficient mice, the inhibitory effect of the alpha(2)-receptor agonist on norepinephrine and dopamine release was significantly reduced but not abolished. Only in tissues from mice lacking both alpha(2A)- and alpha(2C)-receptors was no alpha(2)-receptor agonist effect on transmitter release observed. The time course of onset of presynaptic inhibition of norepinephrine release was much faster for the alpha(2A)-receptor than for the alpha(2C)-subtype. After prolonged stimulation with norepinephrine, presynaptic alpha(2C)-adrenergic receptors were desensitized. From these data we suggest that two functionally distinct alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), operate as presynaptic inhibitory receptors regulating neurotransmitter release in the mouse CNS.


    PMID:11927164 [PubMed - indexed for MEDLINE]

    Alpha-2A and Alpha-2C blockade results in an increase in epinephrine/Norepinephrine, Basal Ganglia Dopamine, and serotonin levels. The primary perceived effect, for me, is an increase in motivation and goal-fulfillment actions.

    The difference in affinities also can explain Alpha-Yohimbine's distinct lack of anxiety effects as compared to Yohimbine.
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  24. the tl;dr:

    In contrast, the inhibitory presynaptic feedback loop that tightly regulates neurotransmitter release from adrenergic nerves requires two receptor subtypes, α2A and α2C, with similar but complementary effects.

    You blockade the alpha 2 receptor subtypes, and you increase, centrally and peripherally, catecholamine level (and prevent their negative feedback) resulting in a multitude of functional effects.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  25. I just gotta say that I LOVE IT when you show us all sorts of cool info from studies. Having real facts and highlights of issues that are involved in different supplement ingredients and their effects is a great tool.
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