D-POL Has (FINALLY!) Arrived, Full Write up inside

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    D-POL Has (FINALLY!) Arrived, Full Write up inside



    Official D-Pol Write Up



    Introduction

    Athletes and exercise enthusiasts are constantly looking for methods to enhance exercise performance and to gain lean body mass. Of course, improving overall health in the process of physique development is also welcome. Although many dietary supplements are marketed for purposes of improving performance, muscle mass, and health, few such supplements are actually supported by peer reviewed scientific evidence for effect in relation to the specific outcomes of interest. This is particularly true when considering the often paltry dosages of each ingredient included within the finished product. To address the need for a dietary supplement specifically designed to enhance exercise performance, to support gains in lean body mass (via increased circulating testosterone), and to improve overall health, PURUS LABS® has formulated a new product to address these areas of interest.

    Introducing PURUS LABS® d-pol™
    Overview and Rationale for use
    d-pol™ is a new product designed by PURUS LABS®, which adheres to the established guidelines of PURUS LABS® in terms of including only those ingredients that have been used in human subjects via oral ingestion, and reported to promote favorable outcomes in relation to the target areas of interest (e.g., enhanced exercise performance, increased circulating testosterone—potentially leading to increased lean body mass, enhanced overall health). d-pol™ contains a unique blend of ingredients, each carefully selected for their potential impact on physical performance and human health—included at the precise dosage necessary to promote the desired effect (as supported by peer reviewed scientific evidence obtained from studies using human subjects). The text below outlines the ingredients used within d-pol™, while providing a brief summary of the rationale for use.

    d-aspartic acid
    Elevating circulating testosterone has been, is now, and will likely continue to be the objective of many hard training athletes. It is well known that testosterone is associated with gains in both muscle size and strength, in addition to having positive effects on several other vital components of human health. One dietary ingredient reported to produce measureable gains in circulating testosterone is d-aspartic acid (DAA). d-aspartic acid has been reported in multiple animal and in vitro studies to be involved in testosterone synthesis, in species ranging from boar (Lamanna et al., 2007a) to lizard (Raucci et al., 2005). It also stimulates the production of other hormones such as prolactin, leutinizing hormone (LH), and growth hormone. Finally, DAA acts as a neurotransmitter/neuromodulator (D'Aniello, 2007)—an effect noted in several studies using animal models and in vitro experiments.

    Considering the sound evidence for a role of DAA in testosterone synthesis, a human study was recently performed to assess the effectiveness of oral DAA supplementation with regards to testosterone elevation (Topo et al., 2009). Subjects included 43 men (27-37 yrs), 20 who received a placebo and 23 who received a DAA supplement (3.12 grams of DAA combined with B-vitamins—the same dosage of DAA provided within d-pol™). The supplement was delivered orally for 12 days. Following the 12 days of treatment with the supplement, 20 of the 23 subjects (87%) had significantly higher circulating LH levels, with an average increase of 33%. With regards to circulating testosterone, 20 of the 23 subjects (87%) had significantly higher values at day 12 compared to pretreatment, with an average increase of 42%.
    For both LH and testosterone, the changes were time dependent—a greater increase was observed on day 12 compared to day 6 of treatment. Therefore, it is possible that continued treatment with the supplement may have resulted in a further increase in these variables. Although measurements of muscle size and strength were not included in this study, it is possible that the increase in circulating testosterone may be associated with a measureable increase in these variables. Further work is needed to confirm these effects.

    While the above findings are interesting and may prove beneficial to those seeking a natural method of increasing circulating testosterone, it should be noted that DAA has been reported to increase aromatase activity, as measured using boar testes (Lamanna et al., 2007b). At the present time it is unknown what amount of DAA would need to be orally ingested by humans in order to promote this effect. No adverse outcomes were noted in the Topo et al. (2009) investigation. Regardless, as with other testosterone stimulating agents, a cyclic schedule of supplementation of d-pol™ is recommended. If adhering to this recommendation, and when considering the inclusion of vitamin D within d-pol™, it may be wise to cycle “off” during periods of optimal sunlight exposure (when natural vitamin D synthesis would be highest—see text below for additional information pertaining to this).

    B-vitamins
    B-vitamins constitute an entire group of water soluble vitamins, with multiple known
    biochemical effects within the body—as evidenced by the thousands of scientific reports
    documenting such effects. B-vitamins have known effects in relation to increasing the rate of
    metabolism, enhancing immune function, and promoting cell growth and division. Of greatest
    importance in relation to the use of these vitamins within d-pol™, the B-vitamins have been used
    in combination with DAA for purposes of elevating circulating testosterone: B9 (folic acid),
    B6 (pyridoxine), and B12 (cyanocobalamin). Because dietary folic acid is not well metabolized to
    the active form by some individuals due to a genetic defect within the folate pathway, the
    naturally occurring form of this vitamin (folate) is included within d-pol™.

    Nitrate
    Nitrate is an inorganic anion abundant in vegetables (e.g., beets, spinach) and converted within the body to nitrite in the entero-salivary circulation (Duncan et al., 1995). The study of nitrate, nitrite, and bioactive nitrogen oxides including nitric oxide, is of great interest to investigators, due to the multiple biological roles of the nitrate-nitrite-nitric oxide pathway (Lundberg et al., 2009).

    A relatively new area of investigation is now focused on the use of nitrate supplementation for purposes of improving exercise performance (Bailey et al., 2009; 2010; Lansley et al., 2010; Larsen et al., 2007; 2010; Vanhatalo et al., 2010). In general, the findings from this work indicate an increase in circulating levels of nitrite following nitrate supplementation (possibly suggesting an increase in circulating nitric oxide), in addition to a lower oxygen cost during exercise. Interestingly, these findings are observed after just a few (e.g., 4-7) days of nitrate supplementation. Such results may translate into lower perceived effort at any given submaximal workload or an increase in the actual amount of work that subjects are able to perform during a given exercise session.

    While this area of research remains in its infancy, additional studies inclusive of outcome measures beyond blood nitrite and oxygen cost of exercise are needed to more fully detail the ergogenic benefits of nitrate supplementation. To date, the majority of this work has been performed in the laboratory of Professor Andrew Jones at Exeter University in the UK, using beetroot juice as the delivery vehicle for nitrate. In much of this work, subjects ingest 500mL of beetroot juice (providing approximately 350mg of dietary nitrate—the same dosage provided within d-pol™). Other work has used dietary nitrate directly (e.g., sodium nitrate), with the dosage based on subjects’ body mass.

    As stated, findings from these studies indicate an increase in circulating levels of nitrite and a reduction in the oxygen cost during exercise. While most exercise studies have involved aerobic work, one recent investigation has focused on resistance exercise (Bailey et al., 2010). In this study, subjects received beetroot juice for six consecutive days and completed a series of low-intensity and high-intensity "step" exercise tests on the last 3 days of supplementation for the determination of the muscle metabolic (using (31)P-MRS) and pulmonary oxygen uptake (VO2) responses to exercise. As is typical, on days 4-6, beetroot juice resulted in a significant increase in blood nitrite. During low-intensity exercise, beetroot juice attenuated the reduction in muscle phosphocreatine concentration and the increase in VO2. During high-intensity exercise, beetroot juice reduced VO2 slow components and significantly improved exercise time to exhaustion. Moreover, the total rate of ATP turnover was estimated to be less for both low-intensity and high-intensity exercise. The authors concluded that the reduced oxygen cost of exercise following nitrate supplementation appears to be due to a reduction in the ATP cost of muscle force production. These findings are further supported by a recent investigation noting an improvement in mitochondrial efficiency with nitrate supplementation (Larsen et al., 2011), a finding that is also correlated to the reduction in oxygen cost during exercise. Collectively, these changes appear to allow exercise to be tolerated for a greater period of time—which may translate into more repetitions being performed during a given set of exercise and/or a greater load to be used during each set of exercise. For aerobic exercise bouts, the duration of exercise may be increased following supplementation. These are indeed findings of interest to any exercise enthusiast.

    Aside from a performance benefit, nitrate supplementation has been reported to lower blood pressure in humans (Kapil et al., 2010; Vanhatalo et al., 2010; Webb et al., 2008), as discussed recently (Ferreira & Behnke, 2010; Gilchrist et al., 2011). Dietary nitrate has been reported to prevent endothelial dysfunction induced by an acute ischemic insult in the human forearm and to attenuate ex vivo platelet aggregation in response to collagen and ADP (Webb et al., 2008). These effects, coupled with the vasodilatory effects of increased circulating nitrite, seem to be responsible for the blood pressure lowering effect of dietary nitrate. While this may not be of primary importance to many athletes, a reduction in blood pressure should at least be of interest to individuals, in particular those who use bodybuilding drugs known to cause elevations in both resting and stress-induced blood pressure. From a general health point of view, a slight reduction in blood pressure is correlated to a lower risk of cardiovascular disease.

    In addition to the above benefits of nitrate supplementation, it has been noted that nitrate may also improve the absorption of certain nutrients. While this appears of some interest, because such findings are isolated to designs not involving oral ingestion of nitrate by human subjects, the potential for improved absorption of nutrients following nitrate ingestion it is not a major consideration for the inclusion of nitrate within d-pol™. If such effects on enhanced nutrient absorption are apparent with nitrate ingestion, this would simply be an adjunct to the well-documented performance and health benefits that are observed.

    Finally, it is important to address the potential safety concern over ingestion of dietary nitrate, which has been raised (Derave & Taes, 2009; Petróczi & Naughton, 2010), with more specific concern over ingestion of high amounts of dietary nitrite (Lundberg et al., 2011). This has been appeased in recent years by experts working specifically in this area of research (Benjamin et al., 2009; Gilchrist et al., 2010). The general consensus is that ingestion of low amounts of dietary nitrate appears safe and may be associated with improvements in parameters of health (e.g., vascular function) and physical performance.

    Vitamin D
    Vitamin D is a fat-soluble vitamin with multiple known functions within the body (Holick, 2004; Sutton & MacDonald, 2003; Thacher & Clarke, 2011), ranging from the maintenance of normal calcium metabolism to a modulator of cellular immunity. Vitamin D3 (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B radiation from sunlight. Vitamin D can also be obtained from the diet. Unfortunately, vitamin D is found naturally in very few foods. According to the Linus Pauling Institute, “foods containing vitamin D include some fatty fish (mackerel, salmon, sardines), fish liver oils, and eggs from hens that have been fed vitamin D. In the U.S., milk and infant formula are fortified with vitamin D so that they contain 400 IU (10 mcg) per quart. However, other dairy products, such as cheese and yogurt, are not always fortified with vitamin D. Some cereals and breads are also fortified with vitamin D. Recently, orange juice fortified with vitamin D has been made available in the U.S.”

    Based on the above, vitamin D supplementation is likely required by most individuals. This is particular true if exposure to natural sunlight is limited and/or the use of sunscreen in routine. In fact, it has been reported that the majority (87%) of adults living in the relatively sunny climate of Tennessee are deficient in vitamin D (Long et al., 2011); a finding that is well supported by numerous investigations including adults (Holick, 2007), in addition to those including children. Individuals residing in parts of the country where the amount and intensity of sunlight is less than average may be at even greater risk for deficiency. Without adequate dietary intake and/or natural synthesis of vitamin D, multiple components of physical health may be compromised—again, a well documented outcome that has fueled the continued growth of vitamin D research.

    Activated vitamin D (calcitriol) has been referred to as a pluripotent pleiotropic secosteroid hormone (Cannell et al., 2009). As a steroid hormone regulating more than 1000 vitamin D-responsive human genes, vitamin D may influence athletic performance. Most of the studies supporting the role of vitamin D with regards to exercise performance involved older adults. However, as noted by Cannell and colleagues (2009) in a recent review article on the topic “physical and athletic performance is seasonal; it peaks when 25-hydroxy-vitamin D levels peak, declines as they decline, and reaches its nadir when 25-hydroxy-vitamin D levels are at their lowest.” These findings are underscored by the potential impact that vitamin D has on skeletal muscle, as described recently (Bartoszewska et al., 2010; Ceglia, 2009; Hamilton, 2010). Furthermore, a recent study (Pilz et al., 2011) in healthy men who supplemented with 3332 IU of vitamin D daily for one year, noted a significant increase in total, bioactive, and free testosterone levels. Although this finding requires confirmation through further research, it appears as though some of the noted health-related effects of vitamin D supplementation in men may be mediated through an increase in testosterone. Considering the well-described health effects of vitamin D, coupled with the potential impact of vitamin D on exercise performance, supplementation with this powerful vitamin should be considered by all individuals.

    Research indicates that vitamin D toxicity is very unlikely in healthy individuals when used at amounts less than 10,000 IU/day (Vieth, 1999). However, the Food and Nutrition Board of the Institute of Medicine (IOM) and a recent Clinical Practice Guideline from the IOM in conjunction with the Endocrine Society (Holick et al., 2011) has set a conservative tolerable upper intake level of 4,000 IU/day (100 mcg/day) for all adults. This is similar to the dosage used in many clinical trials and is the dosage provided within d-pol.

    Cofactors for Vitamin D
    For optimal vitamin D absorption, taking vitamin D with the largest meal of the day seems most appropriate (Mulligan & Licata, 2010). Beyond this, it has been suggested that certain vitamin and mineral cofactors are potentially needed for optimal vitamin D action and effect. However, it should be noted that the need for these cofactors is debatable. Moreover, most of these co-factors are present in vitamin/mineral supplements, which most individuals consume regularly. The cofactors of interest include magnesium, zinc, vitamin K2, vitamin A, and boron. With regards to boron, aside from acting as a cofactor for vitamin D, one recent report indicates a testosterone elevating effect of this mineral (Naghii et al., 2010). It is possible that this may enhance the action of DAA on circulating testosterone. However, an earlier report for boron refutes these findings (Green and Ferrando, 1994). Collectively considering the above, boron and other co-factors are not included within d-pol™.

    SUMMARY
    d-pol™ contains a carefully selected blend of ingredients, based on human evidence for effect in relation to multiple aspects of health and performance. While regular and strenuous exercise, as well as optimal dietary intake inclusive of frequent, macronutrient balanced and nutrient dense meals (as well as adequate water intake) should be viewed as most important in the quest for optimal health and physical functioning, use of a dietary supplement such as d-pol™ may be an adjunct to this lifestyle plan. The use of d-pol™ should be considered in a single dosage with the largest meal of the day.

    As with all nutritional supplements, potential users should only use d-pol™ under the guidance of their personal physician. Moreover, because d-aspartic acid (a chief ingredient in d-pol™) has been reported to increase circulating testosterone, d-pol™ should not be used by women. Individuals considering using d-pol™ should be healthy and over the age of 21. Users of d-pol™ should review the product nutrition panel and label for information regarding the ingredients, dosing, and precautions for use. For more information on PURUS LABS® and their other performance/physique-enhancing products, please visit www.puruslabs.net.
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    References


    Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol. 2010 Jul;109(1):135-48.

    Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009 Oct;107(4):1144-55.
    Bartoszewska M, Kamboj M, Patel DR. Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am. 2010 Jun;57(3):849-61.

    Benjamin N, Bailey SJ, Vanhatalo A, Winyard P, Jones AM. Appl Physiol. 2009 Nov;107(5):1678.


    Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson JJ. Athletic performance and vitamin D. Med Sci Sports Exerc. 2009 May;41(5):1102-10.

    Ceglia L. Vitamin D and its role in skeletal muscle. Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):628-33.

    D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34.

    Derave W, Taes Y. Beware of the pickle: health effects of nitrate intake. J Appl Physiol. 2009 Nov;107(5):1677.

    Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, Smith L, Golden M, Benjamin N. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1995 Jun;1(6):546-51.

    Ferreira LF, Behnke BJ. A toast to health and performance! Beetroot juice lowers blood pressure and the O2 cost of exercise. J Appl Physiol. 2010 Dec 23.[Epub ahead of print]

    Gilchrist M, Winyard PG, Benjamin N. Dietary nitrate--good or bad? Nitric Oxide. 2010 Feb 15;22(2):104-9.

    Gilchrist M, Shore AC, Benjamin N. Inorganic nitrate and nitrite and control of blood pressure. Cardiovasc Res. 2011 Feb 15;89(3):492-8.

    Green NR, Ferrando AA. Plasma boron and the effects of boron supplementation in males. Environ Health Perspect. 1994 Nov;102 Suppl 7:73-7.

    Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr. 2003;23:117-145.

    Hamilton B. Vitamin D and human skeletal muscle. Scand J Med Sci Sports. 2010 Apr;20(2):182-90.

    Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362-371.

    Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-281.

    Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP,
    Murad MH, Weaver CM. Evaluation, Treatment, and Prevention of Vitamin D
    Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011 Jun 6. [Epub ahead of print]

    Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F,
    Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ,

    Webb AJ, Ahluwalia A. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010 Aug;56(2):274-81.

    Lamanna C, Assisi L, Vittoria A, Botte V, Di Fiore MM. D-Aspartic acid and nitric oxide as regulators of androgen production in boar testis. Theriogenology. 2007a Jan 15;67(2):249-54.

    Lamanna C, Assisi L, Botte V, Di Fiore MM. Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis. Amino Acids. 2007b Jan;32(1):45-51.

    Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, Dimenna FJ, Gilchrist M, Benjamin N, Jones AM. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol. 2010 Nov 11. [Epub ahead of print]
    Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf). 2007 Sep;191(1):59-66.

    Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B.Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med. 2010 Jan 15;48(2):342-7.

    Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E.
    Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011 Feb 2;13(2):149-59.




    Long AN, Ray MM, Nandikanti D, Bowman B, Khan A, Lamar K, Hughes T,
    Adams-Graves P, Williams-Cleaves B. Prevalence of 25-hydroxyvitamin D deficiency in an urban general internal medicine academic practice. Tenn Med. 2011 Jan;104(1):45-6, 52.

    Lundberg JO, Larsen FJ, Weitzberg E. Supplementation with nitrate and nitrite salts in exercise: a word of caution. J Appl Physiol. 2011 Aug;111(2):616-7.

    Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, ***o A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 2009 Dec;5(12):865-9.

    Mulligan GB, Licata A. Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D. J Bone Miner Res. 2010 Apr;25(4):928-30.

    Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2010 Dec 1. [Epub ahead of print]

    Petróczi A, Naughton DP. Potentially fatal new trend in performance enhancement: a cautionary note on nitrite. J Int Soc Sports Nutr. 2010 Jun29;7:25.


    Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.

    Raucci F, D'Aniello S, Di Fiore MM. Endocrine roles of D-aspartic acid in the testis of lizard Podarcis s. sicula. J Endocrinol. 2005 Dec;187(3):347-59.
    Sutton AL, MacDonald PN. Vitamin D: more than a "bone-a-fide" hormone. Mol Endocrinol. 2003;17(5):777-791.


    Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011 Jan;86(1):50-60.
    Topo E, Soricelli A, D'Aniello A, Ronsini S, D'Aniello G. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol. 2009 Oct 27;7:120.

    Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1121-31. Epub 2010 Aug 11.


    Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69(5):842-856.

    Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 Mar;51(3):784-90.
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    As soon as my loggers for Muscle Marinade get their stuff then I will be giving a BUNCH of DPOL out
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    How about a label?
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    Should have one soon

    Will be full dosed as shown in studies.
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    Quote Originally Posted by Grambo View Post
    Should have one soon

    Will be full dosed as shown in studies.
    So its DAA and a few additions. There is no new novel ingredient here?
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    Quote Originally Posted by oufinny View Post
    So its DAA and a few additions. There is no new novel ingredient here?
    I would say the nitrate bound DAA is pretty novel itself
    "The only good is knowledge and the only evil is ignorance." - Socrates
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    Quote Originally Posted by JudoJosh View Post
    I would say the nitrate bound DAA is pretty novel itself
    This.


    Novel product from proven ingredients. I think we all get a little too excited with the latest and greatest herbs sometimes. Not toward anyone just observation. I know even I do that even after getting burned before lol
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    Serving Size -3 TABLETs
    Servings Per Container- 30

    AMOUNT DV %

    VITAMIN D3(CHOLECALCIFEROL) 4000IU 1000%
    VITAMIN B6(PYRIDOXINE) 2MG 100%
    VITAMIN B9(FOLATE) 400MCG 100%
    VITAMIN B12(CYANOCOBALAMIN) 6MCG 100%
    SODIUM 130MG 5%


    LH/FREE TESTOSTERONE/ATP AMPLIFYING 3600.1MG**
    VAODILATORY OXYGEN SPARING MATRIX

    D-Apartic Acid (3,120mg),Nitratine(std. for 73% Nitrates),
    Vitamin D3(Cholecalciferol)(4,000IU)

    Other ingredients: silicified microcrystalline cellulose, stearic acid, Carbopol TM (controlled/extended release polymer) , furned silica


    D-Pol usage: Take 1 serving with a mixed food meal 60 minutes prior to intese exercise, preferably with a multivitamin/multimineral, which may aid in Vitamin D absorbtion. For optimal results, use in conjunction with Muscle Marinade to aid in nutrient delivery and uptake. Avoid taking immediately prior to bedtime as your body's natural growth hormone release is at its peak. Tolerance to dosing should be assessed by all individuals prior to starting the full dosage of 3 tablets per day.
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    Look real good to me !
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    Quote Originally Posted by JudoJosh View Post
    I would say the nitrate bound DAA is pretty novel itself
    I would think that nitrate bound DAA would be novel. However, this product does not have it. Hopefully all the writeups and/or threads are being corrected, ya know?
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    Quote Originally Posted by Force of Green View Post
    I would think that nitrate bound DAA would be novel. However, this product does not have it. Hopefully all the writeups and/or threads are being corrected, ya know?
    I am happy that the question was answered but what does the addition of nitrates do to DAA? Is there a study that shows it helps bio-availability or something like that?
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    Quote Originally Posted by Force of Green View Post
    I would think that nitrate bound DAA would be novel. However, this product does not have it. Hopefully all the writeups and/or threads are being corrected, ya know?
    Thanks for helping me get the answers out on these threads. I get busy.

    I hope everyone saw my reply in the promo section.

    Notice the actual write up does not mention it being bound at all and again shows it was more a mistake on my part. Happens.
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    Quote Originally Posted by oufinny View Post
    I am happy that the question was answered but what does the addition of nitrates do to DAA? Is there a study that shows it helps bio-availability or something like that?
    Here you go Oufinny, from the write up:

    "In addition to the above benefits of nitrate supplementation, it has been noted that nitrate may also improve the absorption of certain nutrients. While this appears of some interest, because such findings are isolated to designs not involving oral ingestion of nitrate by human subjects, the potential for improved absorption of nutrients following nitrate ingestion it is not a major consideration for the inclusion of nitrate within d-pol™. If such effects on enhanced nutrient absorption are apparent with nitrate ingestion, this would simply be an adjunct to the well-documented performance and health benefits that are observed."

    Cliffs:
    Maybe it helps some with absorption but not a main consideration for inclusion
    It basically stands alone in the product to improve performance while the DAA increases testosterone


    Anything else let me know!
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    I love DAA and I love Purus Labs. I will definitely try this product as soon as I finish my upcoming cycle. I just picked up a bottle of Organ Shield from my local supp shop to start my pre-loading, and I would have picked up more if they had it. You guys are a standup company with standup products, and I will try anything that you put out.
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    Can you take d-pol with recycle or us it the same thing
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    Quote Originally Posted by TMLAROCK213 View Post
    Can you take d-pol with recycle or us it the same thing
    You can definitely take them together, and are actually a great stack!
    If you use both you are basically hitting just about every natural test boosting compound on the market. I recommend it for sure.
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    What's a good mixed food meal to take with d-pol
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    Quote Originally Posted by TMLAROCK213 View Post
    What's a good mixed food meal to take with d-pol
    I wouldn't worry too much about taking it with a specific meal but something with a little fat will help the vitamin D absorption. I love this product personally. Best one we make these days IMO.
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    Thanks... I really appreciate the feedback... I am trying it out... I am about 6 weeks into a 32 week phase training program. So like some avacado and turkey should do it...
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    Just finished my bottle, good strength gains for me, lost 2 lbs I liked it. Only thing is it makes my piss smell like death
    Always willing to learn :D
  22. Sunz out, Gunz out...
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    D-Pol bump!
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    Hello D-Pol, my old friend,
    Ive come to lift with you again,
    Because my test was barely creeping,
    Nitrates build while I was sleeping,
    And the pumps were pushed into my veins,
    Still remains,
    Within the muscle membraiiins.


    I wrote that for u
    FINAFLEX REP
    Please visit our website at http://finaflex.com.
    ​" If you're looking for a work house.......I'm no Clydesdale."
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    Quote Originally Posted by Montego1 View Post
    Hello D-Pol, my old friend,
    Ive come to lift with you again,
    Because my test was barely creeping,
    Nitrates build while I was sleeping,
    And the pumps were pushed into my veins,
    Still remains,
    Within the muscle membraiiins.


    I wrote that for u
    lol wutttttt, someone has alot of free time on their hands
    Always willing to learn :D
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    BAM
    Purus Labs Anabolic Titan/Rep
    Coach AB @ BossBody.net
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    Quote Originally Posted by Montego1 View Post
    Hello D-Pol, my old friend,
    Ive come to lift with you again,
    Because my test was barely creeping,
    Nitrates build while I was sleeping,
    And the pumps were pushed into my veins,
    Still remains,
    Within the muscle membraiiins.

    I wrote that for u
    WoW that's deep! D-Pol Is sick
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    My review of the NEW Strawberry Cheesecake D-Pol!!!!

    Strawberry Cheesecake D-Pol from Purus Labs Review
    Getting PUMPED with iForce Compete + Hemavol!!!
    http://anabolicminds.com/forum/supplement-reviews-logs/208823-getting-pumped-iforce.html
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    What is the dosing for the d-pol powder? 6 days on 1 day off. 4 weeks on 4 weeks off??
  29. Sunz out, Gunz out...
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    Quote Originally Posted by tank78 View Post
    What is the dosing for the d-pol powder? 6 days on 1 day off. 4 weeks on 4 weeks off??
    60 days straight then a 4 week break.
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    Quote Originally Posted by AaronJP1 View Post
    60 days straight then a 4 week break.
    This is the best protocol
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