I'm taking 5-HTP due to IBS-d and depression with anxiety attacks. I've suffered with this for 23 years. I recently came across some research from the late 1990's about serotonin deficiency that causes IBS-d along with depression, anxiety attacks, insomnia, etc. In the last 6 weeks I have taken Kamut Wheatgrass, NOW's 5-HTP, NOW's Pancreatin, NOW's Gr9-Dophilus and NOW's Acetyl-L Carnitine. My IBS and sleep has improved and my depression with anxiety attacks has been marginalized. I've ordered all of this from best-diet.