Alright Fellas. I have updated my article outlining the effects on DHT in the body, this would go for endogenous DHT or exogenous DHT. This article specifically places emphasis on DHT's role in the brain and nervous system, and how that correlates to extra strength, libido and the "alpha-male" feeling we can associate with gear. Although of course, estrogen plays a little role as well in that feeling.
Everything is SOURCED (referenced) and it is below.
EXCLUSIVE : The What & The How of DHT (Dihydrotestosterone) in the Brain
Many bodybuilders and fitness enthusiasts are going to be thrilled to find out how exactly DHT works in the Brain. What does it do for us there ? Is it really responsible for libido, and if so, what other chemicals does it affect? This article aims to surpass and explain the general knowledge floating around on the Internet and on Forums. I am not a doctor, but I have compiled a nice bunch of references and studies to cite the foundation of this article. I also will explain briefly (an estimate) how someone would feel based on the relative changes due to DHT - discussed in this article.
First off, a basic explanation of DHT (Dihydrotestosterone); it is an androgen (male sex hormone), like Testosterone, which rather than promoting the growth of muscle mass directly (tissue-acting), it acts via intracellular (in the cell) mechanisms to increase strength and metabolism. DHT is not very anabolic, but it is Androgenic, and thus meaning, it promotes masculine characteristics (such as a deeper voice, and growth of facial hair, body hair etc) (1). DHT has a bad rap, since it has been claimed to cause an enlarged prostate, but if you follow the source, *most* of the studies saying this are linked to pharmaceutical promotion of their anti-prostate, anti-Male drug, Finasteride (Propecia) and Dustasteride(2) (3). DHT has also been claimed to cause your hair follicles to become thin, and your hair - subsequently falls out. No. Just No. DHT has been implicated as a factor at most, more studies show that more specifically it is Zinc deficiency AND genetics that provoke male pattern baldness (4)(5). Although Zinc deficiency causes the rise of DHT levels, it also causes increases in prolactin, and estrogen, thus the real problem here *could* have to do with either of those hormones. Just to clarify, Anti-ESTROGEN drugs have been used recently to treat prostate enlargement (BPH), and they are very successful, with less side-effects(6) (7) (8) (9). So if they were wrong about DHT causing prostate enlargement, maybe they were wrong about DHT and hair loss too.
DHT - HOW IT AFFECTS THE BRAIN - AND NERVOUS SYSTEM
But anyway, we got carried away. Let's go on to discuss DHT's effects in the Brain.
DHT has pronounced effects on neurochemistry (it affects neurotransmitters in the brain). DHT has been shown to increase circulating epinephrine levels (adrenaline), this can cause anxiety in predisposed individuals, however, most of the time, this is not the case, since DHT also increases GABA activity in the brain, which is relaxing (10) (11) (12). So in other words, DHT should promote A focused, calm burst of energy, which is what many users of DHT-based steroids, report as the "alpha-male" feeling (13) (14). Dihydrotestosterone increase central and nervous system energy production by increasing not just adrenaline, but cyclic AMP (15). This molecule increase thermogenesis (fat-burning and heat production)(16). Cyclic AMP facilitates the conversion of TSH thyroid hormone, to T4, a more potent thyroid hormone, thus, indirectly, DHT increases thyroid function (by increasing cyclic AMP) (17).
So seeing all this, DHT definitely acts as a nervous system stimulant, and a metabolic "probe", it also increases GABA. Second to this though, it could indirectly decrease serotonin or serotonin receptors; since DHT antagonizes estrogen activity, and estrogen helps maintain the expression of serotonin receptors in the brain(18) (19). This is also consistent with DHT being shown to stop estrogen induced prolactin release(20). Clearly DHT has anti-depressant effects, since Finasteride causes depression (21) and also based on the above mentioned activity of DHT in the brain. It gives energy, it gives focus, it gives aggression.
DHT also improves spatial working memory(22), according to some studies, by altering NMDA-receptors(23) (namely increasing), and by improving Calcium-induced acetylcholine release & function in the hippocampus(24)(25); a very important area of the brain involved in memory formation and spatial (directional) memory.
Finally, Dihydrotestosterone, or it's metabolite 3-alpha-Diol; downregulate alpha-adrenergic receptor distribution, leading to more inhibitory adrenergic (adrenaline influence)(26) (27) (28). For those who don't know, adrenaline can activate an 'alpha receptor' - which stimulates the nervous system, vasoconstricting blood vessels and arteries, raising blood pressure, or it can activate a beta-adrenergic receptor, generally vasodilating artieries, but yet, increasing heart contractile force. This all might just be another result or a reflection of what is mentioned above, that DHT increases epinephrine, GABA, and cyclic AMP. However, in a separate study, Testosterone (without specificity), had upregulated alpha-1-receptors to protect the heart against ischemia(29). Is this an effect of Testosterone or it's metabolites though. Likely, it doesn't matter, it was probably case coincidental, but may indicate that if blood pressure falls too low, Testosterone can increase it to maintain homeostasis.
So DHT via multiple pathways increases nervous system strength, DHT increases epinephrine levels, decreases prolactin (assuming you have enough dopamine production as well), increases GABA, may decrease serotonin and serotonin receptors. All-round this means DHT has positive effects on your chemistry and nerve cells. By reducing prolactin, and estrogen, and subsequently serotonin, and also regulating catecholamines, by this, DHT can definitely increase libido, and alleviate sexual anxiety in most individuals by increasing GABA. DHT is key to many of Testosterone's brain benefits. Keep in mind though, despite positive effects on brain chemistry, this still doesn't give an excuse to OD on aromatase inhibitors, likely, because you need a little bit of estrogen (not much at all), to promote nNOS (neuronal nitric oxide synthase) production. So DHT serves as a great compliment to a little bit of brain estradiol, and a great ratio of DHT to estrogen means optimal sex drive, stamina, charisma and general masculinity.
Let's summarize in Bullets Here.
- DHT regulates alpha and beta adrenergic receptors.
- DHT facilitates the release of Epinephrine (adrenaline).
- DHT increases cyclic AMP.
- DHT blocks estrogen-induced prolactin release.
- DHT reduces serotonin and serotonin receptors by inhibiting estrogen influence in the Brain.
- DHT increases GABA and GABA-A (neurosteroid-specific) receptor expression.
- DHT increases NMDA-receptors in the Hippocampus.
- DHT increases Ca3 (Calcium) evoked Acetylcholine Function(AcH release).
- DHT increases nervous system strength and regulates blood pressure.
HERE IS THE URL ORIGINAL FORM
There is no difference, but out of respect for this forum, it's members and administrators, I have posted IN forum first, before linking off-forum to my blog.
WHERE TO BUY DHT GEL ONLINE
A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
"The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction" Proverbs 1:7
Great post! I love Masteron& Proviron
Love me some DHT
Stano is also DHT correct?
Sub'd also. Great post bud!
I'm on 100g of carbs/day...in other words, ATM, I am not a very happy person :/
National Level NPC Competitor
Sponsored Athlete for Muscle Gauge Nutrition
Nice stuff man!
Log is updated on blog site, please check it out folks!
"DHT reduces serotonin and serotonin receptors by inhibiting estrogen influence in the Brain."
I never knew that does this mean a compound like stanodrol can interact negatively with an SSRI or worsen depression in certain people because it usually makes me feel quite ok.
Very good info here, seems that we are always 'relearning' things we 'thought' we knew. One can freely assume, though, that many 'conclusive' research results by pharmaceutical companies are heavily biased.
An interesting observation - A lot of the effects of DHT on the brain/CNS, are similar to the drug Stablon (tianeptine).
For anyone curious, it is legal to import Stablon into North America.
Everything written by myself is purely fictional and for entertainment purposes. I am not a doctor nor should things I say be taken as medical advice.