Sustain Alpha boosting Testosterone through GABAergic Modulation

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    Arrow Sustain Alpha boosting Testosterone through GABAergic Modulation




    AM members,

    12 months ago, Primordial Performance brought Sustain Alpha to the market as a testosterone boosting topical cream. Since then, this completely legal topical cream has swarmed the market, exceeding virtually all expectations.

    Natural athletes use Sustain Alpha to boost testosterone and reap the benefits from enhanced testosterone levels. For Post Cycle Therapy (PCT), men shun Clomid & Nolvadex for Sustain Alpha to restore testosterone levels faster than ever before. Most importantly, blood tests from actual customers have proven Sustain Alpha to be just as effective as Clomid or Nolvadex for PCT, without the side effects.

    It’s no surprise that Sustain Alpha is so effective. The active ingredients are delivered with an advanced topical delivery cream that pulls them through the skin and straight to the blood stream. Once in the blood, they are carried to the brain – right where they start triggering the testes to produce testosterone like a fountain of youth.

    Speaking of the triggering testosterone production, How does Sustain Alpha work?

    It’s well known, that the main ingredients in Sustain Alpha – resveratrol and 7,8-benzoflavone – are natural anti-estrogens. However, both of these compounds have proven to be very mild anti-estrogens as blood tests have revealed that Sustain Alpha only has a minor effect on total estrogen. (not even close to the aromatase inhibition of a pharmaceutical like Arimidex)

    But that’s ok; Sustain Alpha was never intended to crush estrogen levels. Extremely low estrogen can reduce libido, inhibit recovery, and hurt cholesterol health.

    So the question is…

    If Sustain Alpha isn’t significantly inhibiting estrogen, then how exactly is it significantly increasing LH, FSH and natural testosterone levels?

    It’s because Sustain Alpha is working by other mechanisms besides estrogen modulation.

    Before jumping into the science, here is a brief background on hormone production -

    Basic Hormone Production
    The Hypothalamic Pituitary Testicular Axis (HPTA)

    In a normal healthy male luteinizing hormone (LH) and follicle stimulating hormone (FSH) are sent from the brain (the pituitary) to stimulate the testes to make testosterone and sperm.

    The release of LH & FSH from the pituitary is stimulated by Gonadotropin Releasing Hormone (GnRH) from the hypothalamus. The hypothalamus is stimulated to produce GnRH when it senses low levels of steroid hormones, such as testosterone and estrogen. (hypothalamus [GnRH] --- > pituitary [LH & FSH]--- > testes [testosterone])

    On the other hand, when the brain detects high levels of steroid hormones it suppresses the release of GnRH, LH & FSH, and eventually testosterone production. This is called the negative feedback loop – the normal daily rhythm of hormone production.

    Traditionally, boosting LH & FSH to stimulate testosterone involved the use of a Selective Estrogen Receptor Modulator (SERM) to directly block estrogen at the receptor (eg, Clomid & Nolvadex) or inhibition of estrogen formation by blocking the aromatase enzyme with aromatase inhibitors (eg, ATD, 6-bromo, formestane, Aromasin, Letrozol, ect).
    Now on to the exciting part…

    Recently, it has been found that the main ingredient in Sustain Alpha – the naturally occurring flavone 7,8-Benzoflavone -- increases testosterone production by preventing the negative feedback of testosterone and estrogen on the hypothalamus through GABAergic modulation. (1-10)

    That’s right, GABAergic modulation, but please let me explain before jumping out of your seat.



    As you may know, γ-amino-butyric acid (GABA) is an inhibitory neurotransmitter known to play an important role in sleep, learning, memory and pain sensation. In fact, GABA supplements are often used to promote relaxation and sleep. However, the GABAergic system is a tremendously complex family of receptors which interact not only with GABA, but hundreds of other neuro-active chemicals all throughout the body.

    The important thing to understand here is that GABA and GABAergic transmission are two separate things.

    With that in mind, researchers are just beginning to understand how the GABAergic system regulates the hypothalamus and GnRH secretion.

    So far, it’s been established that there is no androgen receptor (AR) or estrogen receptor (ER) on GnRH releasing neurons. This is fascinating, because it means that steroid hormones such as testosterone and estrogen must communicate with GnRH neurons through intermediaries. Meaning, steroid hormones must signal the release of certain neurotransmitters to suppress GnRH secretion in the hypothalamus. One of the neurotransmitter systems involved in this communication process is the GABAergic system.

    As you can imagine, if the neurotransmitters can be blocked or antagonized, then suppression from steroid hormones can be reduced. This would allow the hypothalamus to continue secreting GnRH, the pituitary secreting LH & FSH, and the testes secreting testosterone.

    Fortunately, Sustain Alpha has the perfect ingredient for this -- 7,8-benzoflavone.

    7,8-benzoflavone is a neuro-active flavone that can pass the blood brain barrier and bind to the GABAergic receptors that modulate GnRH release. (1-10) In fact, animal studies have already shown 7,8-benzoflavone can prevent the drug related decline in LH, FSH and testosterone production. (2-4) By interacting with the GABAergic receptors, 7,8-benzoflavone is able to offset hypothalamic suppression of GnRH from steroid hormones.

    So what does this mean for a guy wanting to boost testosterone?

    This means LH & FSH levels can be boosted quickly and effectively without overly suppressing estrogen and sacrificing sexual health. This means Sustain Alpha is perfect for any PCT, or any male wishing to optimize his “male performance” with higher testosterone levels. This also means that Sustain Alpha is unlike anything else on the market.

    There is one factor that will keep you from getting maximum gains from Sustain Alpha, and that is testicular sensitivity.

    Let me explain…

    No matter how much LH & FSH is secreted, the testes won’t secrete testosterone if they are desensitized to LH & FSH. (which can happen from too much, or not enough stimulation)

    Therefore, maintaining testicular sensitivity is critical, and this is precisely what Toco-8 was designed for.



    Toco-8 is a powdered tocotrienol supplement proven to increase testicular sensitivity. When taken with Sustain Alpha, a powerful synergy occurs. By increasing testicular sensitivity, Toco-8 makes Sustain Alpha 3-4x more effective, thus allowing the body to produce more testosterone than it ever could before. Research has also proven that Toco-8 can increase the effectiveness of hCG by the same mechanism. Consider Toco-8 the beginning of a great testicular awakening – critical for a strong testosterone response to LH & FSH stimulation.

    Make no mistake, this is one of the most powerful testosterone simulating stacks on the market, but don’t take my word for it. Jump on Google or any major bodybuilding forum and put in a search -- you will see Sustain Alpha and Toco-8 are the “real deal”, backed by thousands of positive reviews from actual users.

    Right now, Primordial Performance is throwing a special deal.

    For the next 72hrs you can…

    Save $15 on Sustain Alpha…

    Or...

    Save $25 when you get Sustain Alpha & Toco-8 together!

    All you have to do is put “TESTBOOST” in the coupon field!




    I’d like to thank you for reading this news release and supporting Primordial Performance!

    Yours in health & fitness,

    Eric Potratz (Pp)
    Primordial Founder & President


    Questions?

    Phone – 1-800-568-2924
    Email - info@primordialperformance.com
    Visit - Primordial Performance


    Plus, checkout the feedback below from AM members -


    Originally Posted by EasyEJL

    "...my results were pretty amazing on Sustain alpha + toco-8 as my only PCT items (i also used creatine and x-factor, but neither effects testosterone)

    I really noticed the boys hanging lower than normal even around week two. The final result was about a month after PCT ended. I lost about 10% bodyfat over the timespan between the tests, but I still can't believe my testosterone almost tripled!"


    The Complete Testosterone Recovery Stack
    Originally Posted by Nunchaku

    "Thank you for making products that really works!

    This is the second time i'm using Sustain Alpha and i'm lovin it!
    Like 3 days after I started my PCT I was waking up with morning wood. I'm also using 20mg nolva per day dont feel any need to go higher. I've also just recently added Diesel Test hardcore to the mix.

    I love this newer version of the product, the first one I used worked fine, but that smell!!! I smelled like sausage =\
    I like the smell of the new one =)..."


    Thank you PP

    Originally Posted by buff18

    “Sustain Alpha is a very good product. My libido was far above normal after about a week using it. I really want to run this again in the future. In fact I'd like to run it maybe once every 6 months as a test booster/maintainer.”

    Test.recovery stack?

    Originally Posted by scoooter

    “I'm using the "Testosterone Recovery Stack" completely satisfied. Age:42 not sure if this makes much of a difference compared to a younger male still brimming with real T.

    Packaging, directions: excellent quality, scoops included.

    Website information/details: excellent!

    Customer support/Reps: Very excellent!

    Does this cycle make me repeat "excellent!" ...maybe ? it def eliminate the lethargy I used to have

    Admittedly, the Sustain Alpha took me a while to get used to (my first transdermal experience) but I've become completely used to it. When applied to dry skin its easy to work with but when applied just after a shower (damp skin) took longer to dry. The EndoAMP & Toco-8 powders mix well. I've taken them w/ water, green tea, protien shakes, oatmeal. When ate plain, just eating a whole scoop and washing it down it acted like peanut butter on the roof of my mouth. Taste was plain, like there wasn't any almost. I liked it best in the oatmeal.

    Effectiveness / Comments: 8 out of 10 (if your into rating)

    I've used this as PCT and it has returned a fullness to the boys, very quickly. Libido is good, would't say through the roof, yet. Has kept me very positive and this was the most noticable effect for me. After 2.5 weeks of Sustain when applied now I can actually feel it seeping in my skin, great transport, I now get a very mild / slight warming sensation, way cool.”


    Have you used Primordials Products?

    Originally Posted by gibbob2

    “…You might want to invest in some sustain alpha for a natural test booster, works like a charm it starts to tingle when you apply... in a good way…”

    Best Test Booster for Libido? Need Help for Summer Plz! =)


    Originally Posted by Flyboy

    "Just wondering if I was the only one to have noticed this... it kind of goes against what one might expect from something which should be boosting testosterone.

    For a good few years now I've had a fair few large spots on my back, rarely loads but always enough that i never really had a clear back. Oddly enough they pretty much took up residence after the spots I used to get on my face during my teen years reduced (the buggers just migrated).

    Been using sustain on my shoulders/upper back for probably closing on 2 months now, and my back is as clear as it's ever been. Still get the occasional one but massively, massively reduced. It seems to be related to the application area, as i still got some on the small of my back but since i started also rubbing in a small amount there (it involves some flexibility that stretches the limits of my ability haha!) those have reduced as well.

    Totally unexpected effect, but awesome."


    Sustain Alpha and improved complexion?

    References -

    1. Neuroactive flavonoids interacting with GABAA receptor complex.
    F Wang, M Shing, Y Huen, SY Tsang, and H Xue
    Curr Drug Targets CNS Neurol Disord, Oct 2005; 4(5): 575-85.

    2. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
    K Dhawan and et al.
    Life Sci, Nov 2002; 71(26): 3059-69.

    3. Passiflora: a review update.
    Dhawan K, Dhawan S, Sharma A.
    J Ethnopharmacol. 2004 Sep;94(1):1-23. Review.

    4. Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. – a brief perspective.
    Dhawan, et al.
    Addiction Biology 379-386

    5. A gamma-aminobutyric acidB agonist reverses the negative feedback effect of testosterone on gonadotropin-releasing hormone and luteinizing hormone secretion in the male sheep.
    Endocrinology. 2000 Nov;141(11):3940-5.

    6. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
    Nassiri-Asl M, Shariati-Rad S, Zamansoltani F.
    BMC Complement Altern Med. 2007 Aug 8;7:26.

    7. Effects of Dialyzing γ-Aminobutyric Acid Receptor Antagonists into the Medial Preoptic and Arcuate Ventromedial Region on Lutienizing Hormone Release in Male Sheep.
    Suzie A, et al.
    Biology of Reproduction 58, 1038-1046 (1998)

    8. Antiandrogen Microimplants into the Rostal Medial Preoptic Are Decrease γ-Aminobutyric Acidergic Neuronal Activity and Increase Luteinizing Hormone Secretion in the Intact Male Rat.
    David R et al.
    Endocrinology, Vol. 137 No. 10 (1996)

    9. Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons.
    Nicola Romano, et al.
    Endocrinology, 10.1210/en.2008-0424 (2008)

    10. Restoration of the Luteinizing Hormone Surge in Middle-Aged Female Rats by Altering the Balance of GABA and Glutamate Transmission in the Medial Preoptic Area
    Genevieve S, et al.
    Biol Reprod, Jul 2008; 10.1095/biolreprod.108.069831.

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    Huzzah! Order inbound!

    Just for clarification - is the coupon limited to single orders, or is it $15 dollars off each bottle of Sustain Alpha?
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    Quote Originally Posted by Primordial Perf View Post


    AM members,

    12 months ago, Primordial Performance brought Sustain Alpha to the market as a testosterone boosting topical cream. Since then, this completely legal topical cream has swarmed the market, exceeding virtually all expectations.

    Natural athletes use Sustain Alpha to boost testosterone and reap the benefits from enhanced testosterone levels. For Post Cycle Therapy (PCT), men shun Clomid & Nolvadex for Sustain Alpha to restore testosterone levels faster than ever before. Most importantly, blood tests from actual customers have proven Sustain Alpha to be just as effective as Clomid or Nolvadex for PCT, without the side effects.

    It’s no surprise that Sustain Alpha is so effective. The active ingredients are delivered with an advanced topical delivery cream that pulls them through the skin and straight to the blood stream. Once in the blood, they are carried to the brain – right where they start triggering the testes to produce testosterone like a fountain of youth.

    Speaking of the triggering testosterone production, How does Sustain Alpha work?

    It’s well known, that the main ingredients in Sustain Alpha – resveratrol and 7,8-benzoflavone – are natural anti-estrogens. However, both of these compounds have proven to be very mild anti-estrogens as blood tests have revealed that Sustain Alpha only has a minor effect on total estrogen. (not even close to the aromatase inhibition of a pharmaceutical like Arimidex)

    But that’s ok; Sustain Alpha was never intended to crush estrogen levels. Extremely low estrogen can reduce libido, inhibit recovery, and hurt cholesterol health.

    So the question is…

    If Sustain Alpha isn’t significantly inhibiting estrogen, then how exactly is it significantly increasing LH, FSH and natural testosterone levels?

    It’s because Sustain Alpha is working by other mechanisms besides estrogen modulation.

    Before jumping into the science, here is a brief background on hormone production -

    Basic Hormone Production
    The Hypothalamic Pituitary Testicular Axis (HPTA)

    In a normal healthy male luteinizing hormone (LH) and follicle stimulating hormone (FSH) are sent from the brain (the pituitary) to stimulate the testes to make testosterone and sperm.

    The release of LH & FSH from the pituitary is stimulated by Gonadotropin Releasing Hormone (GnRH) from the hypothalamus. The hypothalamus is stimulated to produce GnRH when it senses low levels of steroid hormones, such as testosterone and estrogen. (hypothalamus [GnRH] --- > pituitary [LH & FSH]--- > testes [testosterone])

    On the other hand, when the brain detects high levels of steroid hormones it suppresses the release of GnRH, LH & FSH, and eventually testosterone production. This is called the negative feedback loop – the normal daily rhythm of hormone production.

    Traditionally, boosting LH & FSH to stimulate testosterone involved the use of a Selective Estrogen Receptor Modulator (SERM) to directly block estrogen at the receptor (eg, Clomid & Nolvadex) or inhibition of estrogen formation by blocking the aromatase enzyme with aromatase inhibitors (eg, ATD, 6-bromo, formestane, Aromasin, Letrozol, ect).
    Now on to the exciting part…

    Recently, it has been found that the main ingredient in Sustain Alpha – the naturally occurring flavone 7,8-Benzoflavone -- increases testosterone production by preventing the negative feedback of testosterone and estrogen on the hypothalamus through GABAergic modulation. (1-10)

    That’s right, GABAergic modulation, but please let me explain before jumping out of your seat.



    As you may know, γ-amino-butyric acid (GABA) is an inhibitory neurotransmitter known to play an important role in sleep, learning, memory and pain sensation. In fact, GABA supplements are often used to promote relaxation and sleep. However, the GABAergic system is a tremendously complex family of receptors which interact not only with GABA, but hundreds of other neuro-active chemicals all throughout the body.

    The important thing to understand here is that GABA and GABAergic transmission are two separate things.

    With that in mind, researchers are just beginning to understand how the GABAergic system regulates the hypothalamus and GnRH secretion.

    So far, it’s been established that there is no androgen receptor (AR) or estrogen receptor (ER) on GnRH releasing neurons. This is fascinating, because it means that steroid hormones such as testosterone and estrogen must communicate with GnRH neurons through intermediaries. Meaning, steroid hormones must signal the release of certain neurotransmitters to suppress GnRH secretion in the hypothalamus. One of the neurotransmitter systems involved in this communication process is the GABAergic system.

    As you can imagine, if the neurotransmitters can be blocked or antagonized, then suppression from steroid hormones can be reduced. This would allow the hypothalamus to continue secreting GnRH, the pituitary secreting LH & FSH, and the testes secreting testosterone.

    Fortunately, Sustain Alpha has the perfect ingredient for this -- 7,8-benzoflavone.

    7,8-benzoflavone is a neuro-active flavone that can pass the blood brain barrier and bind to the GABAergic receptors that modulate GnRH release. (1-10) In fact, animal studies have already shown 7,8-benzoflavone can prevent the drug related decline in LH, FSH and testosterone production. (2-4) By interacting with the GABAergic receptors, 7,8-benzoflavone is able to offset hypothalamic suppression of GnRH from steroid hormones.

    So what does this mean for a guy wanting to boost testosterone?

    This means LH & FSH levels can be boosted quickly and effectively without overly suppressing estrogen and sacrificing sexual health. This means Sustain Alpha is perfect for any PCT, or any male wishing to optimize his “male performance” with higher testosterone levels. This also means that Sustain Alpha is unlike anything else on the market.

    There is one factor that will keep you from getting maximum gains from Sustain Alpha, and that is testicular sensitivity.

    Let me explain…

    No matter how much LH & FSH is secreted, the testes won’t secrete testosterone if they are desensitized to LH & FSH. (which can happen from too much, or not enough stimulation)

    Therefore, maintaining testicular sensitivity is critical, and this is precisely what Toco-8 was designed for.



    Toco-8 is a powdered tocotrienol supplement proven to increase testicular sensitivity. When taken with Sustain Alpha, a powerful synergy occurs. By increasing testicular sensitivity, Toco-8 makes Sustain Alpha 3-4x more effective, thus allowing the body to produce more testosterone than it ever could before. Research has also proven that Toco-8 can increase the effectiveness of hCG by the same mechanism. Consider Toco-8 the beginning of a great testicular awakening – critical for a strong testosterone response to LH & FSH stimulation.

    Make no mistake, this is one of the most powerful testosterone simulating stacks on the market, but don’t take my word for it. Jump on Google or any major bodybuilding forum and put in a search -- you will see Sustain Alpha and Toco-8 are the “real deal”, backed by thousands of positive reviews from actual users.

    Right now, Primordial Performance is throwing a special deal.

    For the next 72hrs you can…

    Save $15 on Sustain Alpha…

    Or...

    Save $25 when you get Sustain Alpha & Toco-8 together!

    All you have to do is put “TESTBOOST” in the coupon field!




    I’d like to thank you for reading this news release and supporting Primordial Performance!

    Yours in health & fitness,

    Eric Potratz (Pp)
    Primordial Founder & President


    Questions?

    Phone – 1-800-568-2924
    Email - info@primordialperformance.com
    Visit - Primordial Performance


    Plus, checkout the feedback below from AM members -


    Originally Posted by EasyEJL

    "...my results were pretty amazing on Sustain alpha + toco-8 as my only PCT items (i also used creatine and x-factor, but neither effects testosterone)

    I really noticed the boys hanging lower than normal even around week two. The final result was about a month after PCT ended. I lost about 10% bodyfat over the timespan between the tests, but I still can't believe my testosterone almost tripled!"


    The Complete Testosterone Recovery Stack
    Originally Posted by Nunchaku

    "Thank you for making products that really works!

    This is the second time i'm using Sustain Alpha and i'm lovin it!
    Like 3 days after I started my PCT I was waking up with morning wood. I'm also using 20mg nolva per day dont feel any need to go higher. I've also just recently added Diesel Test hardcore to the mix.

    I love this newer version of the product, the first one I used worked fine, but that smell!!! I smelled like sausage =\
    I like the smell of the new one =)..."


    Thank you PP

    Originally Posted by buff18

    “Sustain Alpha is a very good product. My libido was far above normal after about a week using it. I really want to run this again in the future. In fact I'd like to run it maybe once every 6 months as a test booster/maintainer.”

    Test.recovery stack?

    Originally Posted by scoooter

    “I'm using the "Testosterone Recovery Stack" completely satisfied. Age:42 not sure if this makes much of a difference compared to a younger male still brimming with real T.

    Packaging, directions: excellent quality, scoops included.

    Website information/details: excellent!

    Customer support/Reps: Very excellent!

    Does this cycle make me repeat "excellent!" ...maybe ? it def eliminate the lethargy I used to have

    Admittedly, the Sustain Alpha took me a while to get used to (my first transdermal experience) but I've become completely used to it. When applied to dry skin its easy to work with but when applied just after a shower (damp skin) took longer to dry. The EndoAMP & Toco-8 powders mix well. I've taken them w/ water, green tea, protien shakes, oatmeal. When ate plain, just eating a whole scoop and washing it down it acted like peanut butter on the roof of my mouth. Taste was plain, like there wasn't any almost. I liked it best in the oatmeal.

    Effectiveness / Comments: 8 out of 10 (if your into rating)

    I've used this as PCT and it has returned a fullness to the boys, very quickly. Libido is good, would't say through the roof, yet. Has kept me very positive and this was the most noticable effect for me. After 2.5 weeks of Sustain when applied now I can actually feel it seeping in my skin, great transport, I now get a very mild / slight warming sensation, way cool.”


    Have you used Primordials Products?

    Originally Posted by gibbob2

    “…You might want to invest in some sustain alpha for a natural test booster, works like a charm it starts to tingle when you apply... in a good way…”

    Best Test Booster for Libido? Need Help for Summer Plz! =)


    Originally Posted by Flyboy

    "Just wondering if I was the only one to have noticed this... it kind of goes against what one might expect from something which should be boosting testosterone.

    For a good few years now I've had a fair few large spots on my back, rarely loads but always enough that i never really had a clear back. Oddly enough they pretty much took up residence after the spots I used to get on my face during my teen years reduced (the buggers just migrated).

    Been using sustain on my shoulders/upper back for probably closing on 2 months now, and my back is as clear as it's ever been. Still get the occasional one but massively, massively reduced. It seems to be related to the application area, as i still got some on the small of my back but since i started also rubbing in a small amount there (it involves some flexibility that stretches the limits of my ability haha!) those have reduced as well.

    Totally unexpected effect, but awesome."


    Sustain Alpha and improved complexion?

    References -

    1. Neuroactive flavonoids interacting with GABAA receptor complex.
    F Wang, M Shing, Y Huen, SY Tsang, and H Xue
    Curr Drug Targets CNS Neurol Disord, Oct 2005; 4(5): 575-85.

    2. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
    K Dhawan and et al.
    Life Sci, Nov 2002; 71(26): 3059-69.

    3. Passiflora: a review update.
    Dhawan K, Dhawan S, Sharma A.
    J Ethnopharmacol. 2004 Sep;94(1):1-23. Review.

    4. Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. – a brief perspective.
    Dhawan, et al.
    Addiction Biology 379-386

    5. A gamma-aminobutyric acidB agonist reverses the negative feedback effect of testosterone on gonadotropin-releasing hormone and luteinizing hormone secretion in the male sheep.
    Endocrinology. 2000 Nov;141(11):3940-5.

    6. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
    Nassiri-Asl M, Shariati-Rad S, Zamansoltani F.
    BMC Complement Altern Med. 2007 Aug 8;7:26.

    7. Effects of Dialyzing γ-Aminobutyric Acid Receptor Antagonists into the Medial Preoptic and Arcuate Ventromedial Region on Lutienizing Hormone Release in Male Sheep.
    Suzie A, et al.
    Biology of Reproduction 58, 1038-1046 (1998)

    8. Antiandrogen Microimplants into the Rostal Medial Preoptic Are Decrease γ-Aminobutyric Acidergic Neuronal Activity and Increase Luteinizing Hormone Secretion in the Intact Male Rat.
    David R et al.
    Endocrinology, Vol. 137 No. 10 (1996)

    9. Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons.
    Nicola Romano, et al.
    Endocrinology, 10.1210/en.2008-0424 (2008)

    10. Restoration of the Luteinizing Hormone Surge in Middle-Aged Female Rats by Altering the Balance of GABA and Glutamate Transmission in the Medial Preoptic Area
    Genevieve S, et al.
    Biol Reprod, Jul 2008; 10.1095/biolreprod.108.069831.
    So if I run dermacrine for two months followed by two months of sustain can I go back and forth between the two every months ?
    •   
       

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    Quote Originally Posted by wheels View Post
    So if I run dermacrine for two months followed by two months of sustain can I go back and forth between the two every months ?
    Theoretically yes.

    In general a good rule of thumb is to be on cycle less than half the year. So it would be a good idea to take an extra month off Dermacrine every few cycles… just to make sure you don’t cause any longterm suppression of your natural testosterone production.

    -Eric
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    Quote Originally Posted by Highlanda01602 View Post
    Huzzah! Order inbound!

    Just for clarification - is the coupon limited to single orders, or is it $15 dollars off each bottle of Sustain Alpha?
    Its only good for the one bottle...

    -Pp
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    LOL @ the subliminal imagery.
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    Quote Originally Posted by chim_chim View Post


    LOL @ the subliminal imagery.
    That is awesome!

    I'd love to give Sustain a try...but not if it turns my balls blue like in the other ad...




    my girlfriend takes care of that already...stupid tease.
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    Quote Originally Posted by Primordial Perf View Post
    Theoretically yes.

    In general a good rule of thumb is to be on cycle less than half the year. So it would be a good idea to take an extra month off Dermacrine every few cycles… just to make sure you don’t cause any longterm suppression of your natural testosterone production.

    -Eric
    I have heard great things about your products.
    But they were a little higher than my budget than some of the bulk stuff I was and am getting.
    With your information on Sustain Alpha I might try some.
    I know you said the on cycle was supposed to be less than half a year.
    Low test seems to be inherited in the men my family.
    From bloodwork with my brothers and I . Plus several of my male cousins .

    Read your cycling info on the product pages.
    During the off periods will the testosterone still be a nice high level?

    I'm asking because I work third shift and part of first shift.
    And my sleep is seriously suffering.
    The Test and GH boosters help me sleep in the daytime.
    Which already makes it hard for my improvement.in lifting and martial arts.

    You guys would not be hiring in the daytime would you?
    lolz.

    Glad I do not celebrate Xmas(except for my little one).
    I can use the money to get some supps.
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    Quote Originally Posted by GuyverX View Post
    I have heard great things about your products.
    But they were a little higher than my budget than some of the bulk stuff I was and am getting.
    With your information on Sustain Alpha I might try some.
    I know you said the on cycle was supposed to be less than half a year.
    Low test seems to be inherited in the men my family.
    From bloodwork with my brothers and I . Plus several of my male cousins .

    Read your cycling info on the product pages.
    During the off periods will the testosterone still be a nice high level?

    I'm asking because I work third shift and part of first shift.
    And my sleep is seriously suffering.
    The Test and GH boosters help me sleep in the daytime.
    Which already makes it hard for my improvement.in lifting and martial arts.

    You guys would not be hiring in the daytime would you?
    lolz.

    Glad I do not celebrate Xmas(except for my little one).
    I can use the money to get some supps.
    You’ve got your get your 8-9 hours of sleep everyday to have an optimum level of testosterone and exercise recovery. The sleep deprivation will kill this.

    Are you needing help setting up a natural T boosting cycle or a pro-hormone PCT plan?

    -Pp
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    Quote Originally Posted by Primordial Perf View Post
    You’ve got your get your 8-9 hours of sleep everyday to have an optimum level of testosterone and exercise recovery. The sleep deprivation will kill this.

    Are you needing help setting up a natural T boosting cycle or a pro-hormone PCT plan?

    -Pp
    I read you guys product page and I will follow the directions on that.
    But do you have any advice on any herbals that would help me sleep?
    I know valerian root is good but only on a temporary basis.
    And melatonin but that kidna works better if you sleep at night.

    I mean I can go full tilt on the exercise and still cant get more than 4 hours straight in the day. Even if I do not work a 2nd job.
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    Quote Originally Posted by GuyverX View Post
    I read you guys product page and I will follow the directions on that.
    But do you have any advice on any herbals that would help me sleep?
    I know valerian root is good but only on a temporary basis.
    And melatonin but that kidna works better if you sleep at night.

    I mean I can go full tilt on the exercise and still cant get more than 4 hours straight in the day. Even if I do not work a 2nd job.
    We have the slumber stack which works nicely without the side effects -

    -Eric
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    Quote Originally Posted by Primordial Perf View Post
    We have the slumber stack which works nicely without the side effects -

    -Eric
    Eric.
    Thank you. I will be most definitely getting some of that as soon as budget permits. In the next week or so.
    I really need it.
  

  
 

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