Let us welcome the revolution in test boosting!!!! "Paragon" - AnabolicMinds.com

Let us welcome the revolution in test boosting!!!! "Paragon"

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    Cool Let us welcome the revolution in test boosting!!!! "Paragon"


    PNI - PARAGON

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    Profile:
    -The industry's most powerful testosterone booster, via multiple mechanisms.
    -Aromatase inhibitor, SHBG inhibitor, and estrogen-receptor antagonist.
    -Ideal for PCT use, or as a standalone T-booster and performance enhancer.


    Ingredients:
    NMDA
    D-Aspartic Acid is incredibly popular as a testosterone booster -- and for good reason, as studies have shown that a dose of 3000mg/day can dramatically increase testosterone levels in men. N-methyl D-Aspartate is simply a more powerful form of DAA: It appears to be 100 times more potent on an equimolar basis (ref), and has a fundamentally-identical mechanism of action. Like DAA, it induces LH release and increases mRNA expression of the steroidogenic acute regulatory protein (StAR) -- a protein which shuttles cholesterol into the mitochondria of steroidogenic cells, and which represents the first rate-limiting step in steroid biosynthesis.
    There's no need to reference DAA studies: NMDA itself has been shown to dramatically increase testosterone in animal models. (ref)


    Menaquinone-4
    MK-4 is the most active form of vitamin K, and is found in high concentrations in the testes. Studies in animals have shown that Vitamin K/MK4 deficiency leads to reduced expression of steroidogenic genes and low testosterone levels (ref); another study has shown that MK-4 supplementation can increase testosterone levels via the induction of protein kinase A, CREB, and, most importantly, P450scc. (ref)
    • PKA is a multi-functional enzyme which activates steroidogenic transcription factors such as steroidogenic factor 1, GATA-4, and the aforementioned StAR. Like StAR, PKA also directly facilitates cholesterol transport into the mitochondria of leydig cells. (ref) PKA is also a positive regulator of the P450scc enzyme.
    • CREB is a upstream regulator of the aforementioned StAR, and increases in CREB expression have been shown to increase StAR promoter activity, StAR mRNA, and StAR protein levels in leydig cells. (ref)
    • P450scc is the 'side-chain-cleavage' enzyme which converts cholesterol to pregnenolone -- and after StAR shuttles cholesterol into the mitochondria of steroidogenic cells, this becomes the rate-limiting step in testosterone biosynthesis. If StAR is sufficiently activated, P450scc is the bottleneck. Paragon amplifies P450scc expression with a hefty dose of MK-4 and destroys this bottleneck, allowing for much greater testosterone production.

    Vitamin D3

    Vitamin D represents another way to boost testosterone levels. Its mechanism of action has not been entirely elucidated, but seems to involve 17b-HSD induction. (ref, ref) While not a rate-limiting step, increases in 17b-HSD enzyme activity should increase the rate of conversion of DHEA to androstenediol, and therefore speed-up testosterone biosynthesis.
    Regardless of mechanism, it's very clear that the stuff works: Vitamin D3 has been shown to increase testosterone levels in healthy adult males (ref), and two recent studies have shown a correlation between serum Vitamin D levels and testosterone levels. (ref, ref) Vitamin D may also improve muscle function (ref, ref) and athletic performance. (ref, ref) Given its many benefits, and its ability to potentially increase testosterone via a seemingly-unique mechanism, its role in Paragon is well warranted.

    Forskolin

    Forskolin is a potent cAMP-activator which should increase testosterone biosynthesis via a now-familiar mechanism: cAMP activation leads to Protein Kinase A phosphorylation and CREB induction, PKA and CREB both potentiate StAR, which then increases transport of cholesterol into the mitochondria. LH itself works in a nearly identical manner. At the dose contained in Prodigy It has been shown to increase testosterone levels in healthy adult men (ref). It also has beneficial effects where body composition is concerned -- due to increases in testosterone and induction of hormone sensitive lipase (HSL), an enzyme which is usually the rate-limiting step in lipolysis. (ref)


    Euonymus Alatus and Prunella Vulgaris extracts

    Widely-used as Chinese herbal medicines, Euonymus Alatus and Prunella Vulgaris deliver a one-two punch to estrogen.
    Euonymous Alatus extract is a potent aromatase inhibitor with an IC50 of 11μm in Human placental aromatase. Animal studies have shown striking results: Treatment with EA extracts can lead to total estrogen deprivation in normal female rats. What's more, it displays selectivity for certain tissue types, and it may be much more selective and active towards aromatase enzymes expressed in breast tissue. This latter property may make it especially useful to people who are prone to gyno. (ref) It may be the most potent herbal aromatase inhibitor on the market today.
    In contrast to Euonymus Alatus, Prunella Vulgaris interferes with estrogen receptor signalling indirectly. An unidentified compound within the extract binds to the aryl hydrocarbon receptor (AHR) as a full agonist, and this ligand-receptor complex seems to degrade the estrogen receptor protein via ubiquitin-mediated mechanisms. It seems to also compete with ER-mediated gene transcription via unknown mechanisms. (ref)
    One thing is certain: Estrogen is of no concern to anybody on Paragon!

    Urtica Dioica extract

    It should be a shame to boost testosterone, only to have it deactivated by SHBG. Urtica Dioica (Stinging Nettle) root extract contains (-)-3,4-divanillyltetrahydrofuran and numerous other inhibitors of SHBG. (ref, ref) We use a full-spectrum aqueous extract, which will help ensure that more of the testosterone you produce is put to good use.

    The bottom line: PARAGON strongly targets every pathway to testosterone production, while still paying attention to estrogen, aromatase, and SHBG. There is no better PCT product on the market, and it's extremely potent as a standalone test-booster.

    References:
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    Are you ready for the revolution?!?!?!?!?
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com

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    Solid ingredients PNI
    Always open light. It’s not what you open with, it’s what you finish with. Louie Simmons
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    That looks very yummy Ricky, and I mean Paragon not your Avi in case you wanna make a pun out of it. Chad has gotten his hands on a serious formulator with a fine brain inside his skull by the looks of this!

    Lets see a logging opportunity, this looks promising Standalone and as the future King of PCTs!! (Along with a SERM of course).
    >SNS-Glycophase<
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    Looks solid. Capsules or powder?

    Also has anyone else noticed that all of PNI's labels look the same? Get some variety in there bro!

    When is it released for sale?
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    Quote Originally Posted by AZMIDLYF View Post
    Solid ingredients PNI
    Thanks bro Im certainly proud of it
    Quote Originally Posted by Celorza View Post
    That looks very yummy Ricky, and I mean Paragon not your Avi in case you wanna make a pun out of it. Chad has gotten his hands on a serious formulator with a fine brain inside his skull by the looks of this!

    Lets see a logging opportunity, this looks promising Standalone and as the future King of PCTs!! (Along with a SERM of course).
    I will be using this in my PCT but yes we may look for a logger or two
    Quote Originally Posted by jimbuick View Post
    Looks solid. Capsules or powder?

    Also has anyone else noticed that all of PNI's labels look the same? Get some variety in there bro!

    When is it released for sale?
    Yeah im not in charge of designing the labels lol Capsules...and the release date hasn't been set yet but I assure you it will be soon
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com
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    Interesting looking profile! I'll try this one out, for sure! When this supposed to be released?
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    Quote Originally Posted by jimbuick View Post
    Looks solid. Capsules or powder?

    Also has anyone else noticed that all of PNI's labels look the same? Get some variety in there bro!

    When is it released for sale?
    Has anyone else noticed that most companie have uniform labels In the future I am sure we will expand on our marketing but our first concern was putting out the most scientifically validated products on the market!!! We have extremely high expectations for this one.

    I see this one landing on some Planet within a week or two!!!
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    This product looks very promising! Nice work!
    PES Representative
    http://pescience.com/insider http://facebook.com/pescience
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    Quote Originally Posted by LiveToLift
    This product looks very promising! Nice work!
    I'm hoping people see that this can be a staple in pct
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com
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    Quote Originally Posted by howwedo107

    I'm hoping people see that this can be a staple in pct
    I'll check out the full ingredient profile and dosing when I get home. If dosed properly the product looks like it could easily be an all in one pct with a serm of course...
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    I am always willing to put my fuzzy butt on the line to log your creations.
    Also here is my response to getting to log something.
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    http://anabolicminds.com/forum/cycle-info/223429-abscent-minded-log.html
    Quote Originally Posted by csa2179 View Post
    Pin the kittens with the tren, then attack the judges with the kittens, uppity bastards
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    looking good man!
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    Looks awesome. Could it be stacked with D-Test?
    After a year off, I'm back
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    Quote Originally Posted by Cary K
    Looks awesome. Could it be stacked with D-Test?
    No need to stack DAA with NMDA...
    >SNS-Glycophase<
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    Quote Originally Posted by Celorza View Post
    No need to stack DAA with NMDA...
    Ok, just wondered
    After a year off, I'm back
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    "Paragon" Who REALLY wants to try this???

    get in on this brothers!!!
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com
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    Should I just start writing my paychecks over to you, Chad? lol ;-) Congrats on all the success with PNI. It is well deserved.
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    Quote Originally Posted by 01slonoma
    Should I just start writing my paychecks over to you, Chad? lol ;-) Congrats on all the success with PNI. It is well deserved.
    You can sign them to me haha thank you sir we work very hard everyday to accomplish everything
    Email me for free prodigy samples
    Ricky@pni-online.com
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    This looks awesome! Nice job on this one PNI!
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    For 30$ you can't really go wrong with at least trying this plus a free tee actually lol
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com
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    Quote Originally Posted by howwedo107 View Post
    For 21$ you can't really go wrong with at least trying this
    Only $21?! That's insane!
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    Quote Originally Posted by jimbuick

    Only $21?! That's insane!
    Nutraplanet has amazing prices and it's 30 plus a free shirt the thermadex fat burner is 21$ my bad guys still an awesome deal
    Email me for free prodigy samples
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    What do the Ts look like?
    Always open light. It’s not what you open with, it’s what you finish with. Louie Simmons
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    Quote Originally Posted by AZMIDLYF
    What do the Ts look like?
    http://www.nutraplanet.com/product/p...s-t-shirt.html
    Email me for free prodigy samples
    Ricky@pni-online.com
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    This stuff looks really interesting. Going to have to find some time in the future to see what it's all about for myself. Hopefully we'll see some logs here soon.
    “Beastmode is when you can not possibly go any further, but then you make a conscious choice to move forward”.
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    Logging it now friends...

    PNI Paragon Log #1 [Sponsored]

    Follow along.
    I can't believe that God put us on this earth to be ordinary. - Lou Holtz
  

  
 

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