Thermadex...PNI's new innovative fat burner...well its here!!!

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    Thermodex is PNI's introductory fat-burner, and it has been carefully engineered using the most advanced and potent ingredients possible. Much more than just another "AMP" clone, we've created an entirely new type of fat-burning product, as we designed it to reflect our belief that:

    1. A 'fat-loss' product should preferentially burn fat, while helping you hold on to your hard-earned muscle.
    2. Stimulation is desirable, but over stimulation can be detrimental due to rebound effects & muscle catabolism.
    3. For a fat-loss product to be extraordinarily effective, every lipolytic pathway needs to be targeted.


    In keeping with principle #3, Thermodex selectively targets fat cells and destroys them without mercy, using every weapon at science's disposal: It elevates UCP expression in white adipose tissue, directly hits alpha and beta adrenoreceptors, induces catecholamine release, activates thermogenesis-inducing vanilloid receptors, blocks PPAR-gamma, shifts the body's preferential energy source from glycogen to free fatty acids, and inhibits cAMP breakdown. To get into the details of how it manages to do all this, we'll need to speak about the ingredients.

    Fucoxanthin is a non-provitamin A carotenoid present in edible seaweed. Like many carotenoids, it is a potent antioxidant (ref); it is also a tremendous, yet much-neglected, ingredient for fat-loss. In mice, it has been shown to increase UCP-1 (uncoupling protein 1) protein expression in white adipose tissue by five-fold, and UCP-1 mRNA expression by an average of twelvefold (ref). No other legal ingredient even comes close. What's more, fucoxanthin potently suppresses the function of PPAR-gamma, a fatty-acid-activated nuclear hormone receptor which kickstarts adipocyte differentiation and plays a pivotal role in lipogenesis. (ref) A study in human subjects has shown that fucoxanthin is more bioavailable in humans than it is in mice (ref) -- and, in another human study geared towards examining the ingredient's fat-loss properties, 8 milligrams per day of fucoxanthin had an almost-unbelievably potent effect. (ref) Thermodex contains a big dose of fucoxanthin at over 16 milligrams per day. This will ensure that the UCP furnace is burning, and that PPAR-gamma doesn't get an opportunity to put the brakes on your fat-loss endeavors.

    Capsaicin, like fucoxanthin, is also an inducer of uncoupling proteins and an inhibitor of PPAR-gamma. (ref, ref) As an uncoupler, it's appears to be weaker than fucoxanthin, but it has a multitude of other biological effects. As a strong TRPV1 agonist, it directly initiates thermogenesis; it promotes adrenal NE secretion (ref); it reduces food intake in humans (ref, ref); it is a PPAR-alpha agonist & increases insulin sensitivity (ref); most interestingly, oral administration of capsaicin potently increases IGF-1 serum levels in humans. (ref)
    These effects might be very long-lived: Capsaicin-treated rats had increased insulin sensitivity and a tendency to leanness a full year after treatment ceased! (ref)

    Bitter orange extract contains phenethylamine alkaloids such as hordenine, synephrine, octopamine, methylsynephrine, tyramine, and N-methyl-tyramine. These compounds can release norepinephrine (ref), inhibit its reuptake (ref), activate alpha/beta receptors (ref, ref), and activate TAAR1 (ref). These amines don't need much introduction, as they're in just about every commercial 'fat-loss' product out there. None of them can hold a candle to their ancestor ephedrine, and they fall a little bit short as standalone fat-loss agents... but they can impart mental focus, energy, and even mild euphoria. For reasons of alpha/beta adrenoceptor stimulation, they also work extremely well with the other lipolytic and thermogenic ingredients in Thermodex. We use only the highest quality bitter orange extracts, standardized to 90% phenethylamine alkaolids.

    Orchidlean (TM) is a proprietary extract from orchids in the cymbidium and ophrys genera. The centerpiece of this blend is a highly-purified fraction from cymbidium goeringii, the "noble orchid", which has extremely potent vasodilator and diuretic properties. (ref) As a vasodilator, it ensures that the heat generated from those thermogenic stimulants and uncouplers can efficiently leave the body - so you won't experience any serious thermogenesis-related discomfort. As an unmatched diuretic, far above comparison to cheap and ineffective dandelion root extracts, it'll make sure that subcutaneous water doesn't obscure your new definition. This particular orchid extract has been used for thousands of years in China and the Himalayas as a diuretic and vasodilator, and feedback from our testers has been unanimously positive. This 'auxillary' ingredient (in the sense that it doesn't directly promote fat-loss) makes a world of difference, and elevates Thermodex to new heights of effectiveness.

    Methylxanthines (caffeine, theophylline, and theobromine) are adenosine-antagonists which reduce fatigue and inhibit the PDE-mediated breakdown of cAMP. In doing so, these methylxanthines increase metabolic rate (ref), stimulate lipolysis via cAMP accumulation (ref), increase endurance via shifting energy utilization from glycogen to fatty acids (ref), and they synergistically potentiate the effects of stimulants with different mechanisms of action (ref). So they do more than just stimulate, they help the other ingredients work better. The methylxanthine ratio in Thermodex was carefully designed to provide smooth and prolonged energy, with an engineered blend of fast-acting caffeine, hard-hitting theophylline, and long-lasting theobromine. It'll help get you through the day, and it'll optimize the other ingredients as they melt away your body-fat.

    Yohimbine HCL is included in this formula as a highly potent and selective alpha2-receptor antagonist. The alpha2 adrenergic receptors are inhibitors of lipolysis (ref), in other words, they tell your body to hold on to fat. What's more, endogenous and synthetic phenethylamines activate these receptors as part of a negative-feedback system, so having increased levels of norepinephrine isn't always a good thing. Yohimbine short-circuits this negative-feedback system -- it prevents alpha2 receptor activation, and will enhance lipolysis -- especially in "trouble areas" of stubborn fat, as these areas tend to have the highest concentration of alpha-2 receptors. There is an added benefit: Blocking alpha receptors fools your body into thinking that it needs to ramp-up norepinephrine release, which results in a stimulant effect.

    As a uniquely thermogenic fat-loss product, Thermodex shines where its unbalanced and stim-overloaded counterparts fall flat. To summarize, it is:
    -The strongest mitochondrial uncoupler and lipolytic agent on the market today.
    -A potent & long-lasting stimulant.
    -An effective vasodilator & diuretic.


    No fancy claims here guys...just an honest, backed by science fat burner.

    Will there be a promo thread for this? Yes there will be be on the look out for it next week

    Any questions please feel free to ask...we aim to please at PNI...we are a generous company and truly appreciate our customers and loggers
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    very cool - nice to see some new products on the fat burner scene, a lot of nice ones coming out this summer.
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    Quote Originally Posted by Bolanrox
    very cool - nice to see some new products on the fat burner scene, a lot of nice ones coming out this summer.
    For sure...and we have many other innovative products in the works we are all about what works
    Email me for free prodigy samples
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    Prodigy getting some great reviews thus far, I am sure this fat burner will follow in its footsteps! ....have a cut coming up!
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    Quote Originally Posted by wasme
    Prodigy getting some great reviews thus far, I am sure this fat burner will follow in its footsteps! ....have a cut coming up!
    Oh yeah guess you better watch out for our promo bro
    Email me for free prodigy samples
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    Like what this company has in the works here, and with Howwe on the team it has to be a good company!
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    Quote Originally Posted by LiveToLift
    Like what this company has in the works here, and with Howwe on the team it has to be a good company!
    Thank you sir...we will be having plenty of give aways and lots more products hitting the market before you know it
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    Bump
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    Nice.

    Now to figure out where I can use it in the next couple of months. Definitely something I want to try!
    “Beastmode is when you can not possibly go any further, but then you make a conscious choice to move forward”.
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    Quote Originally Posted by howwedo107 View Post
    Oh yeah guess you better watch out for our promo bro
    Definitely will be! Man your current progress is astounding...
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    So possible release in Sept.?

    If so, I might have to run this and Prodigy with what I have coming up. An 8 week run of both with what I have in mind should be a lot of fun.
    “Beastmode is when you can not possibly go any further, but then you make a conscious choice to move forward”.
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    Quote Originally Posted by Colbicide
    So possible release in Sept.?

    If so, I might have to run this and Prodigy with what I have coming up. An 8 week run of both with what I have in mind should be a lot of fun.
    Just don't dose them together and you will be good keep them a min of 4 hours apart and that would be insanely fun! All the pumps and fat melting away oh yeah
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    Yea - Therm @ Breakfast and Lunch. Prod for late afternoon workouts. Could be one help of a stack.
    “Beastmode is when you can not possibly go any further, but then you make a conscious choice to move forward”.
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    Quote Originally Posted by Colbicide
    Yea - Therm @ Breakfast and Lunch. Prod for late afternoon workouts. Could be one help of a stack.
    Yeah I'd say so and when we release our topical weight loss product it will just get better!! Keep an eye out for promos
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    Why not take this and prodigy too close together? Too much stim?
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    Quote Originally Posted by wasme
    Why not take this and prodigy too close together? Too much stim?
    Yeah to much caffeine in one shot bro
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    Could u fine pni folks post a label for this bad boy?
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
    http://anabolicminds.com/forum/workout-logs/240285-chedapaloozas-2014-training.html
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    Quote Originally Posted by chedapalooza
    Could u fine pni folks post a label for this bad boy?
    Of what product bro?
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    Quote Originally Posted by howwedo107

    Of what product bro?
    The one in the thread title
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
    http://anabolicminds.com/forum/workout-logs/240285-chedapaloozas-2014-training.html
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    Quote Originally Posted by chedapalooza View Post
    The one in the thread title
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    Quote Originally Posted by howwedo107

    <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=64 275"/>
    Thanks !
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
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    Quote Originally Posted by chedapalooza

    Thanks !
    What do you think of the ingredient panel?
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    Quote Originally Posted by howwedo107

    What do you think of the ingredient panel?
    It looks great.. Not familiar w the orchid but loving the fucoxan and bitter orange and stim content
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
    http://anabolicminds.com/forum/workout-logs/240285-chedapaloozas-2014-training.html
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    Quote Originally Posted by chedapalooza

    It looks great.. Not familiar w the orchid but loving the fucoxan and bitter orange and stim content
    that's bc it's innovative bro
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    Premium Nutraceuticals

    Show us some love
    Email me for free prodigy samples
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    bump for some feedback from my AM bros!!!
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    Quote Originally Posted by howwedo107
    bump for some feedback from my AM bros!!!
    Bump for samples to give feedback
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
    http://anabolicminds.com/forum/workout-logs/240285-chedapaloozas-2014-training.html
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    Quote Originally Posted by chedapalooza

    Bump for samples to give feedback
    Working on samples at some point we are still growing
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    Hmmm I wonder if anyone would be up to log this? Just wonderinggggggg ;-)
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    Quote Originally Posted by howwedo107 View Post
    Hmmm I wonder if anyone would be up to log this? Just wonderinggggggg ;-)
    You know I am, but then again I was blessed with Prodigy already . Why not give a chance for more people to try em ? Lets have Chad run a promo himself now!! Let the CEO step forth and get some forum interaction !
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    i would love to try a sample, so far i seem to not be handling the new gen of 1,3 dim free fat burners all too well.
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    Quote Originally Posted by Bolanrox
    i would love to try a sample, so far i seem to not be handling the new gen of 1,3 dim free fat burners all too well.
    Will take some getting used to
    "no failure is final, nor is any success"
    Follow my 2014 training and supps!
    http://anabolicminds.com/forum/workout-logs/240285-chedapaloozas-2014-training.html
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    Quote Originally Posted by Celorza

    You know I am, but then again I was blessed with Prodigy already . Why not give a chance for more people to try em ? Lets have Chad run a promo himself now!! Let the CEO step forth and get some forum interaction !
    He interacts in the forums when he can...chad is busy with all the other million aspects of starting a supplement company...hence why he hired me as his Internet marketing director :-) kinda like the movie "cast away" I'm his Wilson haha
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    Quote Originally Posted by howwedo107 View Post
    He interacts in the forums when he can...chad is busy with all the other million aspects of starting a supplement company...hence why he hired me as his Internet marketing director :-) kinda like the movie "cast away" I'm his Wilson haha
    You are far more good looking than wilson my dear. Furthermore you do not have a Spheric shape anymore .
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    Quote Originally Posted by howwedo107 View Post
    He interacts in the forums when he can...chad is busy with all the other million aspects of starting a supplement company...hence why he hired me as his Internet marketing director :-) kinda like the movie "cast away" I'm his Wilson haha
    WILSON!!
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    Quote Originally Posted by Celorza View Post
    You know I am, but then again I was blessed with Prodigy already . Why not give a chance for more people to try em ? Lets have Chad run a promo himself now!! Let the CEO step forth and get some forum interaction !

    You rang sir? As Ricky mentioned I try my absolute best to get on here as much as possible but time is limited.

    I know you miss me though Ceasar I am only a text away!!!
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    Quote Originally Posted by bigswole30 View Post
    You rang sir? As Ricky mentioned I try my absolute best to get on here as much as possible but time is limited.

    I know you miss me though Ceasar I am only a text away!!!
    I know bro just busting yah a bit haha. And yeah, it is quite nice to have yah on a reachable position even in Mexico !
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    Quote Originally Posted by howwedo107
    That is a damn good deal. Is that sale price or will that remain?
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    Quote Originally Posted by LiveToLift

    That is a damn good deal. Is that sale price or will that remain?
    Sale price brother
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