If you're newer to PL then this is definitely possible as your body will still be adjusting to being under big weight and getting technique right. If you want to make gains this way though, prioritize the compounds and do low reps.
If you're looking for supplements go for BCAA's. They'll help your body keep muscle in a caloric deficit, even though in a deficit your protein synthesis wont be as high as degeneration.
I think, especially if you're somewhat new, you will lose mass but can gain strength in a deficit.