Coop's Corner #1: Forskolin + B-agonists

  1. Coop's Corner #1: Forskolin + B-agonists


    This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.


    Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.


    Here is the paper I'm referencing: Forskolin Potentiates Isoprenaline-Induced Glycerol Output and Local Blood Flow in Human Adipose Tissue in vivo - Enoksson - 2009 - Pharmacology & Toxicology - Wiley Online Library.


    Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.


    B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
    Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon


    Happy fat loss everyone!


  2. Hi Mr Cooper,

    Really enjoyed you articles on yohimbine, forskolin, and B2 receptors. I wanted to see if you'd weigh in on my recomp stack as I was looking to build it off your articles and comments.

    Before breakfast (low carb/high protien): Dexaprime/ALA/Green coffee bean(50%)/Forskolin-95 25-50mg
    Prelunch MISS cardio: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
    Before lunch (low carb/high protien): ALA/Green coffee bean/Recompadrol
    PreWO: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
    PostWO shake: 50%/50% carb/whey +2g creapure
    PostWO meal (mid carb/high protien)l: fish oil/ALA/Green coffee bean/Recompadrol/Slin-sane

    Change dosing? Change sups?
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  3. comment?

    Don't know if this would occur in other tissues




    Eur J Pharmacol. 1990 Jan 10;175(2):203-5.





    Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.



    Mante S, Minneman KP.



    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322.



    Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.

  4. Quote Originally Posted by sheepdog.tx View Post
    Hi Mr Cooper,

    Really enjoyed you articles on yohimbine, forskolin, and B2 receptors. I wanted to see if you'd weigh in on my recomp stack as I was looking to build it off your articles and comments.

    Before breakfast (low carb/high protien): Dexaprime/ALA/Green coffee bean(50%)/Forskolin-95 25-50mg
    Prelunch MISS cardio: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
    Before lunch (low carb/high protien): ALA/Green coffee bean/Recompadrol
    PreWO: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
    PostWO shake: 50%/50% carb/whey +2g creapure
    PostWO meal (mid carb/high protien)l: fish oil/ALA/Green coffee bean/Recompadrol/Slin-sane

    Change dosing? Change sups?
    Looks very good if you can tolerate the yohimbine + dexaprine. You can remove the carbs from your postworkout shake (no demonstrated benefit). Take your ALA and GCB with carbs rather than with a low carb meal

    Quote Originally Posted by raptor2003 View Post
    comment?

    Don't know if this would occur in other tissues




    Eur J Pharmacol. 1990 Jan 10;175(2):203-5.





    Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.



    Mante S, Minneman KP.



    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322.



    Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.
    It wouldn't. Adenosine (caffeine's target) plays a HUGELY different role in the CNS

  5. Alpha t-2 is the **** - just sayin'
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  6. Thoughts on taking forskolin during PCT to minimize fat gains while keeping calories high?
  7. AnabolicMinds Site Rep
    Driven2lift's Avatar

    Quote Originally Posted by ion26 View Post
    Thoughts on taking forskolin during PCT to minimize fat gains while keeping calories high?
    Can't hurt, for an even better PCT stack I would add ABE, but Forskolin is great solo as well.
    PEScience Representative; Use the code Driven for 30% off at pescience.com

  8. Quote Originally Posted by ion26 View Post
    Thoughts on taking forskolin during PCT to minimize fat gains while keeping calories high?
    Quote Originally Posted by Driven2lift View Post
    Can't hurt, for an even better PCT stack I would add ABE, but Forskolin is great solo as well.

    What driven said. I am no PCT expert, but I've also seen Coop mention specifically about Forskolin being something worth using in PCT as well.
    PEScience Representative
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  9. In! Great thread coop, thoughts on forskolin a value in a lean bulk

  10. Quote Originally Posted by daAMx View Post
    This is definitely VERY SMART stacking.
    But there are other natural beta-agonists; Muira Puama extract is one(1).
    I've seen quite a few in nature and we've tested some of them. The extract b-agonists don't really play out as well for whatever reason, but we're playing with a few now that rock

  11. I been using AS forskolin 95 since 26 march. Started at 50mg and and now 100-150mg a day. I still got one bottle left, should I use it, even though i will be exceeding a 12 weeks run if i do?

  12. Quote Originally Posted by Pec.Major View Post
    I been using AS forskolin 95 since 26 march. Started at 50mg and and now 100-150mg a day. I still got one bottle left, should I use it, even though i will be exceeding a 12 weeks run if i do?
    You can finish up that last bottle if you want.

    Have you enjoyed your Forskolin-95 during this time? Always appreciate some feedback.
    PEScience Representative
    Don't miss out on the next deal:
    http://pescience.com/insider
    Protein Backed by Science: http://selectprotein.com

  13. Quote Originally Posted by bolt10 View Post
    You can finish up that last bottle if you want.

    Have you enjoyed your Forskolin-95 during this time? Always appreciate some feedback.
    Nice!

    Yes most certainly, I am on a bulk (permabulk hehe) and I have almost not gained any noticeable fat at all! The weight have been going up very slowly even though my calorie surplus would be something around 500-1k over maintenance (hard gainer I suppose). Body composition looks solid as well, made some noticeable gains.
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