Coop's Corner #1: Forskolin + B-agonists
- 01-28-2014, 12:38 AM
Coop's Corner #1: Forskolin + B-agonists
This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.
Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.
Here is the paper I'm referencing: Forskolin Potentiates Isoprenaline-Induced Glycerol Output and Local Blood Flow in Human Adipose Tissue in vivo - Enoksson - 2009 - Pharmacology & Toxicology - Wiley Online Library.
Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.
B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon
Happy fat loss everyone! - 01-28-2014, 11:58 AM
Hi Mr Cooper,
Really enjoyed you articles on yohimbine, forskolin, and B2 receptors. I wanted to see if you'd weigh in on my recomp stack as I was looking to build it off your articles and comments.
Before breakfast (low carb/high protien): Dexaprime/ALA/Green coffee bean(50%)/Forskolin-95 25-50mg
Prelunch MISS cardio: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
Before lunch (low carb/high protien): ALA/Green coffee bean/Recompadrol
PreWO: Forskolin-95 25-50mg, Dexaprime XR + Yohimbine 2.5mg at start, 25 and 45 min mark
PostWO shake: 50%/50% carb/whey +2g creapure
PostWO meal (mid carb/high protien)l: fish oil/ALA/Green coffee bean/Recompadrol/Slin-sane
Change dosing? Change sups? -
- 02-02-2014, 12:09 AM
comment?
Don't know if this would occur in other tissues
Eur J Pharmacol. 1990 Jan 10;175(2):203-5.
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
Mante S, Minneman KP.
Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322.
Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects. - 02-02-2014, 01:56 AM
Looks very good if you can tolerate the yohimbine + dexaprine. You can remove the carbs from your postworkout shake (no demonstrated benefit). Take your ALA and GCB with carbs rather than with a low carb meal
It wouldn't. Adenosine (caffeine's target) plays a HUGELY different role in the CNS - 02-05-2014, 10:55 PM
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- 02-24-2014, 12:20 AM
- 02-24-2014, 07:51 AM
- 02-24-2014, 08:10 AM
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- 03-22-2014, 06:45 PM
- 04-16-2014, 12:51 AM
- 05-14-2014, 09:34 AM
I been using AS forskolin 95 since 26 march. Started at 50mg and and now 100-150mg a day. I still got one bottle left, should I use it, even though i will be exceeding a 12 weeks run if i do?
- 05-14-2014, 09:54 AM
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- 05-14-2014, 12:03 PM
Nice!
Yes most certainly, I am on a bulk (permabulk hehe) and I have almost not gained any noticeable fat at all! The weight have been going up very slowly even though my calorie surplus would be something around 500-1k over maintenance (hard gainer I suppose). Body composition looks solid as well, made some noticeable gains.
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