Amentoflavone

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  1. Quote Originally Posted by Quadzilla99 View Post
    Probably doesn't matter; I think the effects last for several hours iirc. neuron used to have a great writeup on it but its gone from his blog now
    Thanks Quadz!


  2. Due to the antagonistic effects on angiogenesis from amentoflavone and (transdermal) ursolic acid respectively, would it be ideal to run them separately for maximum benefit?
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  3. Quote Originally Posted by PharmAnalyst View Post
    Due to the antagonistic effects on angiogenesis from amentoflavone and (transdermal) ursolic acid respectively, would it be ideal to run them separately for maximum benefit?
    Nah, neither matters unless you have a pre-cancerous condition

  4. Given that both affect the GABAergic system, would it be advisable to avoid combining picamilon and amentoflavone?

  5. Quote Originally Posted by PharmAnalyst View Post
    Given that both affect the GABAergic system, would it be advisable to avoid combining picamilon and amentoflavone?
    Yes, take the picamilon away from when you dose your amentoflavone.
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  6. Quote Originally Posted by PharmAnalyst View Post
    Given that both affect the GABAergic system, would it be advisable to avoid combining picamilon and amentoflavone?
    Quote Originally Posted by Synapsin View Post

    Yes, take the picamilon away from when you dose your amentoflavone.
    Can u guys elaborate on this? What else should once avoid near amento dosing?
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  7. Double post edit
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  8. Quote Originally Posted by chedapalooza View Post
    Can u guys elaborate on this? What else should once avoid near amento dosing?
    They both act on GABA receptors and their interaction wouldn't be favorable. Other supplements to avoid near amento would be GABA but people don't really take that preworkout.

  9. Thanks
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  10. Quote Originally Posted by Synapsin View Post
    Yes, take the picamilon away from when you dose your amentoflavone.
    Many thanks, I suspected they might interactive negatively but thought it best to consult someone with a better grasp of the two.

  11. None of these interactions would be bad per se. Just expect your picamilon or gaba not to work too well if you take them exactly with amentoflavone

  12. Do you know anything about Methoxy Amentoflavone form Coop?

  13. Quote Originally Posted by PharmAnalyst View Post
    Due to the antagonistic effects on angiogenesis from amentoflavone and (transdermal) ursolic acid respectively, would it be ideal to run them separately for maximum benefit?
    Does this not apply to oral ursolic acid?
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  14. Quote Originally Posted by chedapalooza View Post

    Does this not apply to oral ursolic acid?
    Found this

    in the present study we evaluated the efficacy of UA against tumor growth and angiogenesis in vivo and in vitro and investigated the underlying molecular mechanisms. We found that administration of UA significantly inhibited tumor volume but had no effect on body weight changes in CRC mice, suggesting that UA can suppress colon cancer growth in vivo without noticeable signs of toxicity. In addition, UA treatment reduced intratumoral microvessel density (MVD) in CRC mice, decreased the total number of blood vessels in the CAM model, and dose and time-dependently inhibited the proliferation, migration and tube formation of HUVECs, demonstrating UA's antitumor angiogenesis in vivo and in vitro. Moreover, UA treatment inhibited the expression of critical angiogenic factors, such as VEGF-A and bFGF. Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways. Collectively, our findings suggest that inhibition of tumor angiogenesis via suppression of multiple signaling pathways might be one of the mechanisms whereby UA can be effective in cancer treatment

    http://www.ncbi.nlm.nih.gov/m/pubmed/24042330/

    Important for me since colon cancer runs on my mothers side of the family.
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  15. These findings indicate that amentoflavone inhibits angiogenesis by disrupting the integrity of endothelial cells and by altering the endogenous factors that are required for the process of neovascularization.

    http://www.ncbi.nlm.nih.gov/m/pubmed/18298378/

    From what I am gathering, these two products should help inhibit angiogenesis. May I ask what led you to ask if they should be used with caution RE stimulating angiogenesis?
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  16. Quote Originally Posted by dinot1985 View Post
    Do you know anything about Methoxy Amentoflavone form Coop?
    I do not.

    As to all these angiogenic posts, they have no relevance to anything, good or bad

  17. Here's another Amento question: I see some literature suggesting putative anti-inflammatory properties of amentoflavone, and even an inhibition of nitric oxide synthase. Would this make it a poor coupling in situations where you're promoting inflammation, e.g. an ArA cycle? I'm sure the effects are too subtle to matter otherwise, but if you're going all-out to optimize ArA by including lodhra, GMS, and carnitine, it'd seem like it would make sense to avoid amentoflavone if it had deleterious effects.

  18. Quote Originally Posted by Nyrin View Post
    Here's another Amento question: I see some literature suggesting putative anti-inflammatory properties of amentoflavone, and even an inhibition of nitric oxide synthase. Would this make it a poor coupling in situations where you're promoting inflammation, e.g. an ArA cycle? I'm sure the effects are too subtle to matter otherwise, but if you're going all-out to optimize ArA by including lodhra, GMS, and carnitine, it'd seem like it would make sense to avoid amentoflavone if it had deleterious effects.
    It would not interfere. We aren't avoiding anti-inflammatories with ArA, we're avoiding fish oil and COX-2 inhibitors

  19. Quote Originally Posted by chedapalooza View Post
    These findings indicate that amentoflavone inhibits angiogenesis by disrupting the integrity of endothelial cells and by altering the endogenous factors that are required for the process of neovascularization.

    http://www.ncbi.nlm.nih.gov/m/pubmed/18298378/

    From what I am gathering, these two products should help inhibit angiogenesis. May I ask what led you to ask if they should be used with caution RE stimulating angiogenesis?
    No idea how I missed that question, sorry. At the time I was stacking pump spray and amentomax. While my emphasis at the time was recomposition and fat loss, I had also been considering (but not actively researching) possible beneficial effects of angiogenesis on conditions marked by increased vascular resistance.

  20. Tried 1 cap Amentomax PWO last night for the first time. I can't be positive it was all because of the Amento, but I had more fun in the gym than I have had since last year. Even coming back after I f**ked my wrist up with a modified workout. I seemed to be chomping at the bit to get more sets done, seemed to recover faster between sets, and most of all, I was in such a bright mood the whole time.

    Granted, I am coming back from an injury, so I am enjoying being back in general, but something just seemed different about the whole experience. I can't wait to try this again.

  21. Quote Originally Posted by tyrub42 View Post
    Tried 1 cap Amentomax PWO last night for the first time. I can't be positive it was all because of the Amento, but I had more fun in the gym than I have had since last year. Even coming back after I f**ked my wrist up with a modified workout. I seemed to be chomping at the bit to get more sets done, seemed to recover faster between sets, and most of all, I was in such a bright mood the whole time. Granted, I am coming back from an injury, so I am enjoying being back in general, but something just seemed different about the whole experience. I can't wait to try this again.
    That sounds like the usual benefits of amentoflavone.

    Mood elevation and increased workout performance are always plentiful for me.
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  22. Quote Originally Posted by bolt10 View Post
    That sounds like the usual benefits of amentoflavone.

    Mood elevation and increased workout performance are always plentiful for me.
    Yep, sounds like a classic amentomax moment to me!

  23. Quote Originally Posted by tyrub42 View Post
    Tried 1 cap Amentomax PWO last night for the first time. I can't be positive it was all because of the Amento, but I had more fun in the gym than I have had since last year. Even coming back after I f**ked my wrist up with a modified workout. I seemed to be chomping at the bit to get more sets done, seemed to recover faster between sets, and most of all, I was in such a bright mood the whole time. Granted, I am coming back from an injury, so I am enjoying being back in general, but something just seemed different about the whole experience. I can't wait to try this again.
    Definitely sounds like what others are experiencing as well
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  24. Amentoflavone also antagonizes kappa opioid receptors; this would also lead to expressional reductions in phosphodieasterase activity..in which that means, amentoflavone is a direct and indirect PDE inhibitor
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265593/
    http://en.wikipedia.org/wiki/%CE%9A-opioid_receptor
    http://www.longecity.org/forum/topic...ization-stack/

  25. Quote Originally Posted by damage007 View Post
    Amentoflavone also antagonizes kappa opioid receptors; this would also lead to expressional reductions in phosphodieasterase activity..in which that means, amentoflavone is a direct and indirect PDE inhibitor
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265593/
    http://en.wikipedia.org/wiki/%CE%9A-opioid_receptor
    http://www.longecity.org/forum/topic...ization-stack/
    Indeed, AmentoMax would help with erection quality because of this mechanism.
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