- 01-13-2014, 11:49 PM
Primary effect: Fat Loss
Mechanism: Beta-adrenergic receptor agonism and increases in uncoupling proteins
Body fat mass reduction and up-regulation of ... [Int J Biol Sci. 2009] - PubMed - NCBI
Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract.
Mori S, Satou M, Kanazawa S, Yoshizuka N, Hase T, Tokimitsu I, Takema Y, Nishizawa Y, Yada T.
We have found natural products exhibiting lipolysis-promoting activity in subcutaneous adipocytes, which are less sensitive to hormones than visceral adipocytes. The activities and a action mechanisms of a novel plant extract of Cirsium oligophyllum (CE) were investigated in isolated adipocytes from rat subcutaneous fat, and its fat-reducing effects by peroral administration and topical application were evaluated in vivo. CE-induced lipolysis was synergistically enhanced by caffeine, a phosphodiesterase inhibitor, and was reduced by propranolol, a beta adrenergic antagonist. The peroral administration of 10% CE solution to Wistar rats for 32 days reduced body weight gain, subcutaneous, and visceral fat weights by 6.6, 26.2, and 3.0%, respectively, as compared to the control group. By the topical application of 2% of this extract to rats for 7 days, weight of subcutaneous fat in the treated skin was reduced by 23.2%. This fat mass reduction was accompanied by the up-regulation of uncoupling protein 1 (UCP), a principal thermogenic mitochondrial molecule related to energy dissipating, in subcutaneous fat and UCP3 in skin except for the fat layer. These results indicate that CE promotes lipolysis via a mechanism involving the beta adrenergic receptor, and affects the body fat mass. This fat reduction may be partially due to UCP up-regulation in the skin including subcutaneous fat. This is the first report showing that repeated lipolysis promotion through CE administration may be beneficial for the systematic suppression of body fat accumulation or the control of fat distribution in obesity.
Besides increasing lipolysis via beta adrenergic receptor stimulation and increases in uncoupling protein expression, Cirsium Oligophyllum acted synergistically with caffeine in promoting lipolysis.
The International Congress on Obesity presented the following findings during their 2010 conference:
Margioris, Andrew N., MD. "Nutritional Modification of White to Brown Adipose Tissue Ratio and Its Repercussion on Resting Energy Expenditure (REE)." Proc. of International Congress on Obesity, Sweden, Stockholm. N.p., n.d. Web.
- 01-14-2014, 04:28 AM
Should someone want to sign up for the Norcodrene insider make sure to do it now so you don't miss it.
01-14-2014, 06:22 AM
Hello ben, when is this insider going out ? as this contains Yohimbe would pes be doing a version for the uk ? [to be honest i will order on the insider but just out of curiosity]
01-14-2014, 07:24 AM
The insider is planned for this week.
I shall check about UK formulations.
01-14-2014, 07:50 AM
01-14-2014, 07:57 AM
Reason #1 to want new product. Check.
Definitely going to give it a try, still unsure of what stack to use it in. Thanks Coop
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01-14-2014, 12:56 PM