Cirsium Oligophyllum

  1. Diamond Member
    mr.cooper69's Avatar
    Join Date
    Feb 2011
    Posts
    10,682
    Rep Power
    6883806
    Level
    99
    Lv. Percent
    69.93%
    Achievements Activity AuthorityActivity ProActivity VeteranActivity RoyaltyPosting Pro

    Cirsium Oligophyllum


    Cirsium Oligophyllum

    Primary effect: Fat Loss
    Mechanism: Beta-adrenergic receptor agonism and increases in uncoupling proteins




    Body fat mass reduction and up-regulation of ... [Int J Biol Sci. 2009] - PubMed - NCBI

    Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract.
    Mori S, Satou M, Kanazawa S, Yoshizuka N, Hase T, Tokimitsu I, Takema Y, Nishizawa Y, Yada T.
    Author information
    Abstract
    We have found natural products exhibiting lipolysis-promoting activity in subcutaneous adipocytes, which are less sensitive to hormones than visceral adipocytes. The activities and a action mechanisms of a novel plant extract of Cirsium oligophyllum (CE) were investigated in isolated adipocytes from rat subcutaneous fat, and its fat-reducing effects by peroral administration and topical application were evaluated in vivo. CE-induced lipolysis was synergistically enhanced by caffeine, a phosphodiesterase inhibitor, and was reduced by propranolol, a beta adrenergic antagonist. The peroral administration of 10% CE solution to Wistar rats for 32 days reduced body weight gain, subcutaneous, and visceral fat weights by 6.6, 26.2, and 3.0%, respectively, as compared to the control group. By the topical application of 2% of this extract to rats for 7 days, weight of subcutaneous fat in the treated skin was reduced by 23.2%. This fat mass reduction was accompanied by the up-regulation of uncoupling protein 1 (UCP), a principal thermogenic mitochondrial molecule related to energy dissipating, in subcutaneous fat and UCP3 in skin except for the fat layer. These results indicate that CE promotes lipolysis via a mechanism involving the beta adrenergic receptor, and affects the body fat mass. This fat reduction may be partially due to UCP up-regulation in the skin including subcutaneous fat. This is the first report showing that repeated lipolysis promotion through CE administration may be beneficial for the systematic suppression of body fat accumulation or the control of fat distribution in obesity.


    Besides increasing lipolysis via beta adrenergic receptor stimulation and increases in uncoupling protein expression, Cirsium Oligophyllum acted synergistically with caffeine in promoting lipolysis.

    The International Congress on Obesity presented the following findings during their 2010 conference:






    Margioris, Andrew N., MD. "Nutritional Modification of White to Brown Adipose Tissue Ratio and Its Repercussion on Resting Energy Expenditure (REE)." Proc. of International Congress on Obesity, Sweden, Stockholm. N.p., n.d. Web.
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  2. Diamond Member
    bdcc's Avatar
    Join Date
    Feb 2009
    Posts
    10,451
    Rep Power
    10742715
    Level
    108
    Lv. Percent
    74.59%
    Achievements Activity AuthorityActivity ProActivity VeteranActivity RoyaltyPosting Pro

    Should someone want to sign up for the Norcodrene insider make sure to do it now so you don't miss it.

    http://pescience.com/insider
    PES Representative
    http://pescience.com/insider
    http://selectprotein.com
  3. New Member
    olly2712's Avatar
    Stats
    6'0"  204 lbs.
    Join Date
    Sep 2012
    Posts
    6
    Rep Power
    31
    Level
    2
    Lv. Percent
    39.5%

    Hello ben, when is this insider going out ? as this contains Yohimbe would pes be doing a version for the uk ? [to be honest i will order on the insider but just out of curiosity]
    •   
       

  4. Diamond Member
    bdcc's Avatar
    Join Date
    Feb 2009
    Posts
    10,451
    Rep Power
    10742715
    Level
    108
    Lv. Percent
    74.59%
    Achievements Activity AuthorityActivity ProActivity VeteranActivity RoyaltyPosting Pro

    The insider is planned for this week.

    I shall check about UK formulations.
    PES Representative
    http://pescience.com/insider
    http://selectprotein.com
  5. New Member
    olly2712's Avatar
    Stats
    6'0"  204 lbs.
    Join Date
    Sep 2012
    Posts
    6
    Rep Power
    31
    Level
    2
    Lv. Percent
    39.5%

    Quote Originally Posted by bdcc View Post
    The insider is planned for this week.

    I shall check about UK formulations.
    cheers ben, just got notification that my abe and snickerdoodle is in the uk
  6. Elite Member
    Driven2lift's Avatar
    Stats
    5'9"   lbs.
    Join Date
    Dec 2012
    Age
    25
    Posts
    6,273
    Rep Power
    7475019
    Level
    95
    Lv. Percent
    40.05%
    Achievements Activity AuthorityActivity ProActivity VeteranActivity RoyaltyPosting Pro

    Reason #1 to want new product. Check.

    Definitely going to give it a try, still unsure of what stack to use it in. Thanks Coop
    Athletix Representative
    Orbit Nutrition Representative;
    Use the code SOCIAL for 10% off your order at Orbit!
  7. Senior Member
    cbsharpe's Avatar
    Stats
    6'1"  225 lbs.
    Join Date
    Apr 2008
    Posts
    1,725
    Rep Power
    846833
    Level
    45
    Lv. Percent
    66.21%
    Achievements Activity ProPosting Pro

    also known as "Japanes thistle"...

    Nice write up Coop...
  

  
 

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in