Lodhra (Bark) Extract

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  1. Quote Originally Posted by Whacked View Post
    Refresh my memory. What's in C20?
    http://www.nutraplanet.com/product/u...mpound-20.html


  2. Thanks
    Was too lazy to check myself. Lolol

    Quote Originally Posted by chedapalooza View Post
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
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  3. Bump. Is this is any other products? I have a bottle of ABE anyways lol

  4. Quote Originally Posted by AdelV View Post
    Bump. Is this is any other products? I have a bottle of ABE anyways lol
    Not that I've seen
    PEScience Representative
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  5. Quote Originally Posted by kbayne View Post
    Not that I've seen
    Found it in powder from India cheap! Haha might give it a go
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  6. Is it extracted for the proper compounds? Most Chinese and Indian suppliers sell cheap powder, not even extracted many times (despite claims)

  7. Listen to Coop. Make sure you do your research and don't be too eager just because you see what you think is a "deal."
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  8. Quote Originally Posted by mr.cooper69 View Post
    Is it extracted for the proper compounds? Most Chinese and Indian suppliers sell cheap powder, not even extracted many times (despite claims)
    Mr.cooper... Clear your PM's please.
    FOCUSED NUTRITION REP https://www.facebook.com/focusednutrition1/?fref=ts

  9. "The latter two effects are typically considered unfavorable.
    Lodhra Bark is a lipoxygenase inhibitor, preventing the conversion of ArA to leukotrienes. This leaves more ArA available to be converted to prostaglandins or thromboxanes, the latter of which can be inhibited by methods stated above"

    I re read the post but am still a bit confused on the 'the latter of which can be inhibited by methods stated above' part. That is referring to the conversion to thromboxanes right? But what is it referring to above that is used to inhibit it? I see the above referencing blocking conversion to leukotrienes...

    Quote Originally Posted by mr.cooper69 View Post
    Lodhra Bark Extract
    Aka
    Symplocos Racemosa Extract



    Phosphodiesterase (PDE) Inhibition

    PDE inhibitors are used clinically for erectile dysfunction (PDE5i like Viagra), weight loss, and bronchodilation/asthma treatment.

    Symplocos Racemosa is one of nature’s most well-documented phosphodiesterase inhibitors. Phosphodiesterase is the enzyme responsible for breaking down cyclic-AMP (cAMP). cAMP is a second messenger that has beneficial effects like improved fat loss, increased muscle mass, improved thyroid function, and improved steroidogenesis. Indeed, the very reason forskolin works is because it increases levels of cAMP in the body by increasing levels of the enzyme that creates cyclic AMP.

    A simplified model:

    Enzyme A -> cAMP pool of the body -> Enzyme B

    Enzyme A is creating more cAMP for the aforementioned benefits. This is the enzyme that forskolin increases, resulting in the well-documented effects on human body composition.
    Enzyme B is breaking down cAMP and working against enzyme A. Enzyme B is known as phosphodiesterase (PDE). Symplocos racemosa contains PDE inhibitors, so levels of Enzyme B decrease and levels of cAMP increase. The net result is increased levels of cAMP.

    http://www.ncbi.nlm.nih.gov/pubmed/15643556
    http://onlinelibrary.wiley.com/doi/1...nticated=false
    http://europepmc.org/abstract/MED/12...VmR5GtJexNnE.4


    The specific PDE they tested against in these studies was PDE1, but this does not mean that Lodhra bark is not active against other PDE isoforms. PDE1 inhibition is a mechanism shared by selegiline (Deprenyl), but its main documented role is enhanced pulmonary function, improved energy levels, and increased vasodilation in response to nitric oxide (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650605/).



    Hormonal Effects

    Aside from increasing cAMP which increases steroidogenesis, Lodhra also increases LH/FSH (http://www.ncbi.nlm.nih.gov/pubmed/15261983) and was effective in treating a murine model analogous to secondary infertility. In males, LH is known to stimulate testosterone production while FSH nourishes developing sperm.


    Complementary Effects with Arachidonic Acid (ArA)


    ArA has three primary metabolites: prostaglandins (associated with muscle accretion and vasodilation), thromboxanes (associated with blood clotting; inhibited by carnitines or aspirin), and leukotrienes (associated with constriction of smooth muscle, such as bronchoconstriction). The latter two effects are typically considered unfavorable.
    Lodhra Bark is a lipoxygenase inhibitor, preventing the conversion of ArA to leukotrienes. This leaves more ArA available to be converted to prostaglandins or thromboxanes, the latter of which can be inhibited by methods stated above.

    http://www.ncbi.nlm.nih.gov/pubmed/15938197

  10. Not sure about it. reading ayurveda Lodhra is clearly a herb for female treatments. Mostly for uterine disorders.

    Hormonal Effects

    Aside from increasing cAMP which increases steroidogenesis, Lodhra also increases LH/FSH and was effective in treating a murine model analogous to secondary infertility. In males, LH is known to stimulate testosterone production while FSH nourishes developing sperm.
    This study uses females rat models, (I think) this could be related more to uterine problems than anyone else.

    This study: Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model

    Show results that contradicts what we want, like:

    1 - S. racemosa increases estrogen levels
    2 - S. racemosa increases progesterone levels
    3 - S. racemosa decreases testosterone levels

    The plasma testosterone level in normal control group was observed to be around (235.82依14.98) ng/dL on Day 22 and is
    maintained consistently up to (245.33依13.84) ng/dL on Day 37 indicating the stable condition. After the animals were treated with letrozole for the induction of PCOS, the mean testosterone level in letrozole control group was significantly increased up to (795.20依24.10) ng/dL (P<0.001). Clomiphene citrate treatment led to a significant decrease in testosterone level from (716.37 依28.86) ng/dL to (255.42依17.43) ng/dL. Significant fall of (279.95 依21.30) ng/dL and (273.62依23.07) ng/dL (P<0.001) was recorded when PCOS induced rats were treated with mid and high dose of S. racemosa respectively. Decrease in testosterone level with low dose of S. racemos
    I not sure how this effects could be interpreted to males, but since ayurveda does not have indications for male use of this herb, I not sure of the conclusions that it could led to testosterone increases.
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