Anabeta recent research

[JudoJosh]

Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC.

Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract. Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A. pyrethrum was administered to groups of rats in 50, 100, and 150 mg/kg doses for a period of 28 days, and the action was compared with control and testosterone-treated rats. Thirteen N-alkylamides were detected in the extract by using HPLC/UV/electrospray ionization mass spectrometry method. Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations. Histoarchitecture of testis revealed increased spermatogenic activities. Seminal fructose content was also significantly increased after 28 days of treatment. Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential and may improve male fertility by enhancing spermatogenesis.

[JudoJosh]

[Rodja]

Great find.

[JudoJosh]

Great find.

I will admit I was quite skeptical about anabeta at first but with this it is looking quite promising

[fueledpassion]

Looks like Anabeta could be used in PCT. FSH takes the hardest hit from steroid use, imo. It takes some men as long as 12 months to restore normal fertility in their sperm production after running a cycle of steroids. This could prove to be valuable during and after PCT to get things normal again since taking Clomid longer than 6 weeks isn't as practical.

There aren't many drugs/supps out there that address the issues with FSH so this is encouraging to me.

[R1balla]

Looks like Anabeta could be used in PCT. FSH takes the hardest hit from steroid use, imo. It takes some men as long as 12 months to restore normal fertility in their sperm production after running a cycle of steroids. This could prove to be valuable during and after PCT to get things normal again since taking Clomid longer than 6 weeks isn't as practical.

There aren't many drugs/supps out there that address the issues with FSH so this is encouraging to me.

Duhhhhh. lol. its also helpful for keeping the gains.

[T-Bone]

I love Anabeta but the study you posted was done with 150mg per kilogram. So I calculated that for myself and came out to 7.7625 grams a day. So I would need to take 10 anabeta a day to use the same dosage used in the study. Maybe if I had unlimited funds I would try it but I don't think so. It works fine at the regular dosage for me though.

[Geoforce]

I do wish we could see something with this extract other than just in mice/rats. No real human study has ever been done that I'm aware of.

Like Lyle McDonald is fond of saying..."you're not a mouse." Ah well, maybe some day we will see some human stuff on this.

[JudoJosh]

I love Anabeta but the study you posted was done with 150mg per kilogram. So I calculated that for myself and came out to 7.7625 grams a day. So I would need to take 10 anabeta a day to use the same dosage used in the study. Maybe if I had unlimited funds I would try it but I don't think so. It works fine at the regular dosage for me though.

HED isnt based solely on body weight

[T-Bone]

HED isnt based solely on body weight

Sorry I don't speak nerd. I know nothing about chemistry, explain it to me as if you were talking to a child. Seriously, I'm not being a wise ass.

[DAdams91982]

I do wish we could see something with this extract other than just in mice/rats. No real human study has ever been done that I'm aware of.

Like Lyle McDonald is fond of saying..."you're not a mouse." Ah well, maybe some day we will see some human stuff on this.

If you see a human study come out on, you are almost guaranteed not to see it on the open market. Only people that pay for studies on humans are pharma companies ready to spend a ton of money to release it themselves. This is why TTA is pretty much gone.

[JudoJosh]

I do wish we could see something with this extract other than just in mice/rats. No real human study has ever been done that I'm aware of.

Like Lyle McDonald is fond of saying..."you're not a mouse." Ah well, maybe some day we will see some human stuff on this.

Lets not try to discredit results of a study soley because it isnt on humans. Animal models can be quite useful and are far more practical for researchers to use than human models but yes it doesnt always pan out the same in humans as it does in animals but animal models are indicative of possibilities.

Hopefully one day some human research will be performed but that will largely depend on if the ingredient in question is patenable or not and if their is a medical/pharma intrest in the ingredient.

As I said eariler, I was a big skeptic over anabeta effectiveness (and still am somewhat to a degree) but with this recent study it is looking more like anabeta may actually work

[DAdams91982]

I love Anabeta but the study you posted was done with 150mg per kilogram. So I calculated that for myself and came out to 7.7625 grams a day. So I would need to take 10 anabeta a day to use the same dosage used in the study. Maybe if I had unlimited funds I would try it but I don't think so. It works fine at the regular dosage for me though.

The math is a bit different than you are expecting. It is not a 1 for 1 with regard to dosing. There is a formula out there for getting a human dose with a mouse dose.... I just dont have it on me at the moment.

[R1balla]

i remember seeing a study done on rats when AB first came out (i googled it) and it showed increase testosterone, but not near as detailed as this study

[JudoJosh]

Sorry I don't speak nerd. I know nothing about chemistry, explain it to me as if you were talking to a child. Seriously, I'm not being a wise ass.

It isnt as straightforward as one would think or hope for. Problem is mice metabolize medications, supplements and food at a different rate than humans do. You would need the weight and surface area of both the mouse and human which is the Km (measure of metabolic rate) and with this ratio we can find the HED.

I will try and figure it out later on but cant make no promises as I suck at math. Perhaps one of the PES guys can chime in and do the calculations for you

The math is a bit different than you are expecting. It is not a 1 for 1 with regard to dosing. There is a formula out there for getting a human dose with a mouse dose.... I just dont have it on me at the moment.

Here ya go

HED = Animal dose (mg/kg) x (Animal Km : Human Km)

Reference - http://www.fasebj.org/content/22/3/659.full

[bdcc]

Lets not try to discredit results of a study soley because it isnt on humans. Animal models can be quite useful and are far more practical for researchers to use than human models but yes it doesnt always pan out the same in humans as it does in animals. Hopefully one day some human research will be performed but that will largely depend on if the ingredient in question is patenable or not and if their is a medical/pharma intrest in the ingredient.

As I said eariler, I was a big skeptic over anabeta effectiveness (and still am somewhat to a degree) but with this recent study it is looking more like anabeta may actually work

Out of interest, have you tried it? I don't know many people on here who have tried it and remain sceptical.

[T-Bone]

Ok thanks guys for explaining that to me. Now it makes a lot more sense as to why I don't have to take so much for it to be effective. Always loved anabeta from when I first tried the beta version. Never needed more than 4 a day to see results.

[JudoJosh]

i remember seeing a study done on rats when AB first came out (i googled it) and it showed increase testosterone, but not near as detailed as this study

If I recall correctly no it didnt

http://www.scipharm.at/download.asp?id=346

The researchers hypothesized there was a raise in testosterone due to an increase in the testes weight but never bothered to do any quantitative analysis of androgen levels.

They failed to really give any explanation for its MOA, hence my original skepticism. All the original study showed us was a strong anabolic reaction which was not mediated by the androgen receptor and possibly also boosted testosterone (and again they didnt provide any data for this).



NOTE: my intention is not to bash or discredit anabeta. It is actually the opposite. As I said with this new study combined with the previous one, we are now understanding more about the compound and as I said earlier, it is looking promising

[Geoforce]

Lets not try to discredit results of a study soley because it isnt on humans. Animal models can be quite useful and are far more practical for researchers to use than human models but yes it doesnt always pan out the same in humans as it does in animals but animal models are indicative of possibilities.

Hopefully one day some human research will be performed but that will largely depend on if the ingredient in question is patenable or not and if their is a medical/pharma intrest in the ingredient.

As I said eariler, I was a big skeptic over anabeta effectiveness (and still am somewhat to a degree) but with this recent study it is looking more like anabeta may actually work

Actually was not trying to discredit it, more lamenting the fact that it is unlikely we may see a human study. Clearly mouse studies have their merits and of course they are going to be used for a variety of reasons. But it isn't quite as simple (as I know you are aware) as saying "it did this in mice so it's going to do this in humans."

It's much more than just the size factor coming into play. The compounds that work well on the micro level in the very controlled environment of the research lab (in vitro) on cell or same tissue samples do not always translate equally well to real life/full body tests (in vivo) as there are many more uncontrollable variables there: genetic differences, metabolic differences, biochemical interactions, immunity differences, lifestyle differences, environmental differences, etc times a million.

Was not my intention to try and discredit the study though and obviously when you can't go with humans animal studies are the next best thing. I just wish everything could come with a human trial

[JudoJosh]

Out of interest, have you tried it? I don't know many people on here who have tried it and remain sceptical.

No I have not. I have dramatically reduced my supplement intake and try not to take too much or fall victim to the forum hype of new products but thats not to say I havent considered giving anabeta a try as I do find the product intriguing and the anecdotal feedback as been nothing but stellar thus far

Ok thanks guys for explaining that to me. Now it makes a lot more sense as to why I don't have to take so much for it to be effective. Always loved anabeta from when I first tried the beta version. Never needed more than 4 a day to see results.

no problem

Actually was not trying to discredit it, more lamenting the fact that it is unlikely we may see a human study. Clearly mouse studies have their merits and of course they are going to be used for a variety of reasons. But it isn't quite as simple (as I know you are aware) as saying "it did this in mice so it's going to do this in humans."

It's much more than just the size factor coming into play. The compounds that work well on the micro level in the very controlled environment of the research lab (in vitro) on cell or same tissue samples do not always translate equally well to real life/full body tests (in vivo) as there are many more uncontrollable variables there: genetic differences, metabolic differences, biochemical interactions, immunity differences, lifestyle differences, environmental differences, etc times a million.

Was not my intention to try and discredit the study though and obviously when you can't go with humans animal studies are the next best thing. I just wish everything could come with a human trial

I understand your concerns and agree mostly. In a perfect world we would have human data for everything but alas the world isnt perfect. Again animal models are useful and practical and aren't entirely useless when trying to decide if the same effect would be seen in humans particularly when there are human in vivo studies to confirm the results. Unfortunately right now as it stands, their are no human in vivo studies to confirm it yet but again these studies on anacyclus pyrethrum using the murine model are indicative of possibilities and combine this with the overwhelming anecdotal feedback it is very likely that some of its effects do translate to humans. To what extent, who knows but IMO there certaininly is a possibility that effects do translate.