The Best Just Got Better - PES Erase Pro

[nattydisaster]

**This Thread is for the Discussion of Erase Pro, its use, its formula, and ingredients**

After more than a years worth of phenomenal feedback on Erase, we have decided to formulate an all new, full spectrum, hardcore product - Erase Pro.


Erase will not be going anywhere...but you will now have the option to take the Erase experience to a whole new level.


Erase Pro utilizes hormone modulation like never before. With the addition of two new very exciting ingredients users will experience effects they never even imagined possible with an OTC product.


As a standalone, Erase Pro simultaneously has both AI and SERM-like properties. It can act both as an aromatase inhibitor and as an estrogen receptor antagonist.


Aromatase inhibition is sought after because by inhibiting the conversion of testosterone to estrogen, T goes up and E goes down.


SERMs are sought after because they block estrogen itself from binding to and activating its receptor. By doing this your body senses a need for more estrogen. Since estrogen comes from testosterone, your body signals for more and more testosterone release. This is why SERMs are used heavily in the underground bodybuilding community.


An ingredient in Erase Pro also has animal data on cortisol reduction. Keep the cortisol spike down. You may choose to take your Erase Pro in the morning, or around your workouts. Times when cortisol is highest...be both anabolic and anti-catabolic!


For users of anabolics, this is the absolute best combination of mechanisms for an over the counter PCT. You can see why, with the combination of both AI and ER inhibition. That is how PCTs are designed.


So what can you expect from Erase Pro over Erase?


Even greater physiological effects. We know because we tested it extensively. We had a number of possible ingredients with possible SERM action, and the one we used clearly stood out to us. We spent the time to find the best extraction and the best dose to combine with the Androsta-3,5-diene-7,17-dione.


We have more experience with the original Erase ingredient than anyone...and there is no doubt Erase Pro's formula took the feel to a new level.


Everyone loves the hardening, drying, lean feeling Erase gives. Expect all that and more from Erase Pro.


PES | Physique Enhancing Science.

[nattydisaster]

Boerhaavia diffusa (Root) Extract

Anti-Estrogen via direct Estrogen Receptor Binding

B. diffusa showed potent competitive binding for the estrogen receptor in vitro. The result was less estrogen could bind to the receptor. By preventing E from binding to its receptor it cannot give its undesirable effects on the body.

This is the same mechanism SERMs like Nolva use. As a result your body will signal for more testosterone release in order to hope to also increase estrogen. This is why we included an aromatase inhibitor in Erase Pro.

(Sreekumar Sreeja, Sreeharshan Sreeja; An in vitro study on antiproliferative and antiestrogenic effects of Boerhaavia diffusa L. extracts Journal of Ethnopharmacology, Volume 126, Issue 2, 12 November 2009, Pages 221-225)



Cortisol Modulation in the Animal Model

Data shows that in a stress swim test, animals taking BDE (b. diffusa extract) did not see the significant estrogen spike that control groups saw. The BDE group also had 25% longer swimming times.

Cortisol is the hormone released is stressful situations, especially during physical training. This catabolic hormone has the ability to break down muscle. BDE gives Erase Pro a true anti-catabolic mechanism

(Meera Sumanth and S.S. Mustafa, Antistress, Adaptogenic and Immunopotentiating Activity Roots of Boerhaavia Diffusa in Mice, International Journal of Pharmacology 3 (5): 416-420, 2007)



Diuretic Activity

BDE has also shown to have direct diuretic activity. This fits perfectly in the goal of Erase Pro. Lean...Dry...Hard.

(Gaitonde, B.B., Kulkarni, H.J., and Nabar,S.D. Diuretic activity of punarnava (Boerhaavia diffusa). Bulletins of the Haffkine Institute (Bombay,India) 1974; 2:24)


Alpha-2 Adrenergic Antagonist

You may be familiar with this mechanism if you have real about Alpha-T2, as it is the target pathway in Alpha-T2. Alpha-2 adrenoceptors are receptors in the stomach, love handles, and chest that when turned on are working to STORE fat in those areas. By inhibiting this enzyme you can turn the mechanism off. This is the key pathway to targeted fat loss, most especially belly fat.

(Shigetoshi Kadota et al. Constituents of the Roots of Boerhaavia diffusa L. I. Examination of Sterols and Structures of New Rotenoids, Boerhavinones A and B; Chem Pharm Bull 37(12) 3214-3220 (1989) Vol. 37 No. 12)

[nattydisaster]

Euonymus alatus (Root) Extract

This ingredient caters to those who will be using Erase Pro on cycle and/or PCT. It works under a mechanism known as in-situ inhibition of estrogen. This mechanism is on the forefront of research for developing a way to target estrogen reduction selectively in breast cancer patients.

Those who cycle know that some people are super prone to gyno and seem almost gyno-invincible. The cause of this is some people have more aromatase enzymes in their mammary cells than others.

This ingredient and its mechanism may hold the key to making those who are extremely prone to on-cycle or PCT gyno much less susceptible.

(Lee TK, Kim DI, Han JY, Kim CH. Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells. Immunopharmacol Immunotoxicol. 2004 Aug;26(3):315-27.)

[nattydisaster]

Androsta-3,5-diene-7,17-dione

You guys all already know and love this compound so much...the majority of you have used it. We have given this ingredient at the favorite dose after a years worth of feedback - 75mg per capsule.

Once daily dosing is all you need. In fact, if you find Erase Pro is too strong for you then you can even go to once every other day dosing.

This amazing ingredient is a real, synthetic, irreversible aromatase inhibitor. The data shows a Ki value even better than exemestane, and way better than formestane.

Erase, and this ingredient, are both so popular because of one reason...it works...and works extremely well. 1 capsule of Erase Pro is all you need...how's that for potent?

Each of these ingredients are beasts of their own. We have tested the ingredients singularly and in concert with one another. The result is a truly special and cutting edge hardcore formula.

For serious users only...no matter your goals. It is the ultimate hardening, drying, lean formula you will come across. Use it on bulk, cut, or recomp. You will feel the difference.

(Numazawa M, Mutsumi A, Tachibana M, Hoshi K; Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase; J Med Chem. 1994 Jul 8;37(14):2198-2)

[Cordeen]

Effects on libido? Just sounds that this will be pretty strong and those really estrogen sensitive, should be cautious no?

[kevinhy]

Effects on libido? Just sounds that this will be pretty strong and those really estrogen sensitive, should be cautious no?

I noticed a pretty significant libido boost during testing of these compounds, but your mileage may vary.

[sarguy]

I just ordered!

[nattydisaster]

Effects on libido? Just sounds that this will be pretty strong and those really estrogen sensitive, should be cautious no?

If you are very sensitive to AIs and estrogen reduction, use 1 Erase Pro every other day

[GuyverX]

Looking forward to running Erase Pro.
And it it is really great for a once a day dosing protocol.

[Jasonlb7]

Im currently taking 4 erase a day. Would it make any difference if I took the new erase pro in the am and 1 cap of the original pm?

[Rosie Chee]

Im currently taking 4 erase a day. Would it make any difference if I took the new erase pro in the am and 1 cap of the original pm?

That would be fine - I'll be doing something similar re stacking Erase Pro and Erase.

~Rosie~

[nattydisaster]

Im currently taking 4 erase a day. Would it make any difference if I took the new erase pro in the am and 1 cap of the original pm?

You could do that if you are dead set on 100mg of that ingredient

[Delta Force]

Bump, more people should read this info!!!

[nattydisaster]

Bump, more people should read this info!!!

This thread is where the goods are at

[kevinhy]

This thread is where the goods are at

For sure

[DiEsEL g33k]

I can't wait to try Pro, I am ordering some on Friday!!!!

[Delta Force]

This thread is where the goods are at

For sure.. I'm just waiting for this thread to heat up once more ppl know about it (hence I dropped it on my sig)

[nattydisaster]

When you starting the erase pro delta?

[Delta Force]

When you starting the erase pro delta?

I'm ready to start any day... I'm sure it will be the king of all supps )

[kevinhy]

I'm ready to start any day... I'm sure it will be the king of all supps )

About to start mine in a day or two.