5HTP and Melatonin

  1. New Member
    jaydee's Avatar
    Join Date
    Sep 2006
    Posts
    315
    Rep Power
    256
    Level
    14
    Lv. Percent
    93.47%

    5HTP and Melatonin


    I currently take 200mg of 5HTP daily. I want to add 3mg of Melatonine before bed.

    Does anyone know if these two can be taken together? Do I need to lower the 5HTP dose?

  2. New Member
    bigstabile's Avatar
    Join Date
    Oct 2005
    Age
    33
    Posts
    384
    Rep Power
    303
    Level
    16
    Lv. Percent
    17.22%

    They can definatly be taken together. Just go by how you feel waking up, if the dose is too high you'll feel groggier then you like. You could also add Gaba and/or valerian to that for a great sleep/relaxation stack.
  3. Registered User
    jjohn's Avatar
    Join Date
    Jun 2006
    Age
    27
    Posts
    6,538
    Rep Power
    77390
    Level
    53
    Lv. Percent
    15.8%
    Achievements Activity ProPosting ProPosting Authority

    I agree with bigstabile. Valerian also helps a lot. Stacking them would be safe and effective IMO.
    •   
       

  4. Elite Member
    yeahright's Avatar
    Join Date
    Jul 2005
    Posts
    6,368
    Rep Power
    10345
    Level
    52
    Lv. Percent
    98.1%
    Achievements Activity ProPosting ProPosting Authority

    Try starting with a low dose of melatonin and adjust upward as needed.
  5. New Member
    newequation's Avatar
    Join Date
    Mar 2005
    Age
    33
    Posts
    20
    Rep Power
    127
    Level
    4
    Lv. Percent
    61.64%

    Quote Originally Posted by yeahright View Post
    Try starting with a low dose of melatonin and adjust upward as needed.
    No, thats not how melatonin works. Even a three mg pill is overkill.
  6. rollin' on dubs!
    WannaBeHulk's Avatar
    Stats
    5'9"  178 lbs.
    Join Date
    Dec 2005
    Age
    30
    Posts
    923
    Rep Power
    569
    Level
    23
    Lv. Percent
    52.32%

    Quote Originally Posted by newequation View Post
    No, thats not how melatonin works. Even a three mg pill is overkill.
    i agree, 3 mg is a bit much. it has too long of a half life so i wake up feeling groggy everytime i take melatonin. i like theanine a couple hours before bed and tryptophan .5-1 hour before. works great in my experiences!
  7. Elite Member
    yeahright's Avatar
    Join Date
    Jul 2005
    Posts
    6,368
    Rep Power
    10345
    Level
    52
    Lv. Percent
    98.1%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by newequation View Post
    No, thats not how melatonin works. Even a three mg pill is overkill.
    When I say "low dose" I mean .25 mg and work upwards. I don't understand why people start taking 1, 3 or 5 mg tablets when they have no idea how it will effect them.

    Personally, I've always found buying 1mg tablets and then breaking them into quarters is plenty without leaving any residual grogginess the next day.
  8. rollin' on dubs!
    WannaBeHulk's Avatar
    Stats
    5'9"  178 lbs.
    Join Date
    Dec 2005
    Age
    30
    Posts
    923
    Rep Power
    569
    Level
    23
    Lv. Percent
    52.32%

    Quote Originally Posted by yeahright View Post
    When I say "low dose" I mean .25 mg and work upwards. I don't understand why people start taking 1, 3 or 5 mg tablets when they have no idea how it will effect them.

    Personally, I've always found buying 1mg tablets and then breaking them into quarters is plenty without leaving any residual grogginess the next day.
    thats interesting... i dont know why i never thought to do that. i think a low dose such as .25-.5mg would have done me much better. good thinking there yeahright!
  9. Banned
    0-hero's Avatar
    Join Date
    Jun 2005
    Age
    31
    Posts
    594
    Rep Power
    0
    Level
    19
    Lv. Percent
    43.28%

    Agree with reduced dosing.

    0.5 is ample for me, otherwise i get what ive coined the melatoning hangover
  10. New Member
    jaydesiel4651's Avatar
    Join Date
    Feb 2007
    Posts
    216
    Rep Power
    202
    Level
    13
    Lv. Percent
    23.1%

    i bought the 3 mg pills.. i took two for the first time and it didnt do anything. I actualy slept poorly that night (which i do most nights) but otc sleep never seem to work on me
  11. Senior Member
    MM11's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Nov 2007
    Age
    28
    Posts
    1,818
    Rep Power
    17829
    Level
    31
    Lv. Percent
    64.02%
    Achievements Activity ProPosting Pro

    i may be wrong but melatonin in higher doses has an almost reverse effect. i took 3mg one night then another 3mg an hour later and i was awake all night. i started breaking the caps into little peices(no idea how much but less then 1 mg) and it works much better.
    here is a MIT study about .3mg--->http://web.mit.edu/newsoffice/2005/melatonin.html
    ill look for more
  12. Senior Member
    MM11's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Nov 2007
    Age
    28
    Posts
    1,818
    Rep Power
    17829
    Level
    31
    Lv. Percent
    64.02%
    Achievements Activity ProPosting Pro

    when you think about it melatonin could be almost as cheap as water. 1.95 a bottle online for 3mg caps, broken into little .3mg = 10 nights per cap X 100 caps per bottle = 1000 nights per 1.95!! not a bad deal. i love sleeping
  13. New Member
    INKTOXICATED's Avatar
    Stats
    6'0"  221 lbs.
    Join Date
    Aug 2008
    Age
    34
    Posts
    23
    Rep Power
    87
    Level
    4
    Lv. Percent
    12.46%

    melatonin left me a headache every single morning. sucks only getting 6 hours a sleep a night. the trucker life
  14. New Member
    EdB's Avatar
    Stats
    5'10"  181 lbs.
    Join Date
    Apr 2009
    Posts
    1
    Rep Power
    67
    Level
    1
    Lv. Percent
    0%

    Quote Originally Posted by WannaBeHulk View Post
    i agree, 3 mg is a bit much. it has too long of a half life so i wake up feeling groggy everytime i take melatonin. i like theanine a couple hours before bed and tryptophan .5-1 hour before. works great in my experiences!
    There are much lower doses available, like the 3 mcg tablets from Trader Joe's.
  15. New Member
    Draikaiden's Avatar
    Stats
    6'1"  220 lbs.
    Join Date
    Mar 2009
    Posts
    25
    Rep Power
    81
    Level
    5
    Lv. Percent
    0.73%

    Glad this got bumped. The MIT article is great. I was one of those people that just thought it didnt work that well, when I was really overdosing on 3mg tabs.

    As far as 5-HTP and Melatonin mixed you may be over doing it. 5-htp converts to serotonin for sure. But I read in a magazine that it converts to serotonin AND melatonin.
    I have not found an online article to support this but if you are really going to mix them may be something to look further into.
  16. New Member
    echoenyx's Avatar
    Stats
    5'4"  153 lbs.
    Join Date
    May 2009
    Posts
    4
    Rep Power
    69
    Level
    2
    Lv. Percent
    9.33%

    awesome, thx for all of the info. Great thread.
    I used to take 3mg Melatonin, but shall try less as suggested.
    And about 5-HTP, I take 100mg before bed.
    Is it okay to take during the day also? I heard it helps you sleep etc, curbs cravings...
  17. New Member
    Draikaiden's Avatar
    Stats
    6'1"  220 lbs.
    Join Date
    Mar 2009
    Posts
    25
    Rep Power
    81
    Level
    5
    Lv. Percent
    0.73%

    I read somewhere that people were using 5-htp to curb food cravings. Taking it 20 mins before meals.
  18. New Member
    swoody's Avatar
    Join Date
    Jul 2004
    Age
    32
    Posts
    275
    Rep Power
    0
    Level
    14
    Lv. Percent
    80.67%

    From personal experience, I would not take melatonin any more than what has been suggested in this thread. And it DOES need to by cycled... after prolonged use, it can cause depression a little... I'm not sure how, but it has been documented and when I have not cycled it, this has happend to me every time. When I stopped taking it I felt much better... so tread lightly... like .25 mg for only 2 weeks lightly.
  19. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    881
    Level
    30
    Lv. Percent
    1.05%
    Achievements Activity ProPosting Pro

    Melatonin like most hormone is a bit risky. It needs cycling and risks a feed-back loop.

    5HTP is solid.
  20. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    881
    Level
    30
    Lv. Percent
    1.05%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Draikaiden View Post
    I read somewhere that people were using 5-htp to curb food cravings. Taking it 20 mins before meals.
    Yeah thats possible particularly for girls.
  21. Diamond Member
    strategicmove's Avatar
    Join Date
    Jun 2007
    Posts
    10,754
    Rep Power
    774631
    Level
    68
    Lv. Percent
    25.09%
    Achievements Activity ProActivity AuthorityPosting ProPosting AuthorityPosting Veteran

    Quote Originally Posted by Draikaiden View Post
    ...

    As far as 5-HTP and Melatonin mixed you may be over doing it. 5-htp converts to serotonin for sure. But I read in a magazine that it converts to serotonin AND melatonin....
    Serotonin is infact an intermediate result in the synthesis of melatonin from L-Tryptophan. More precisely, L-Tryptophan is metabolized into 5-Hydroxytryptophan (5-HTP) via the enzymatic action of tryptophan hydroxylase. 5-HTP is enzymatically converted to Serotonin by aromatic-l-amino-acid decarboxylase. In the pineal gland, Serotonin is acetylated via serotonin-n-acetyltransferase to N-acetylserotonin, the rate-limiting step in melatonin synthesis. Finally, N-acetylserotonin is methylated by hydroxyindole-O-methyltransferase to melatonin.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
  22. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    881
    Level
    30
    Lv. Percent
    1.05%
    Achievements Activity ProPosting Pro

    Right that makes sense.

    If you do melatonin exogenase you could limit that pathway which will cause depression. Risky. Do, do 5HTP don't do melatonin.

    Thanks USPlabs - best post I've seen from Strategic.
  23. New Member
    theface's Avatar
    Stats
    6'1"  201 lbs.
    Join Date
    Jun 2006
    Age
    30
    Posts
    345
    Rep Power
    274
    Level
    15
    Lv. Percent
    39.07%

    Quote Originally Posted by jaydee View Post
    I currently take 200mg of 5HTP daily. I want to add 3mg of Melatonine before bed.

    Does anyone know if these two can be taken together? Do I need to lower the 5HTP dose?
    I've taken both together and seen no bad side effects. I asked my doctor about the dosing of melatonin and he said he's instructed patients to take upwards of 15 mg of melatonin. If you check drugs.com or just do a search for drug interactions, you can see what exactly 5-htp interacts with. I believe you aren't allowed to take 5-htp when taking common anti depressants like trazodone and topamax. If I am correct, 5-htp when mixed with these drugs could cause serotonin syndrome.
  24. Diamond Member
    strategicmove's Avatar
    Join Date
    Jun 2007
    Posts
    10,754
    Rep Power
    774631
    Level
    68
    Lv. Percent
    25.09%
    Achievements Activity ProActivity AuthorityPosting ProPosting AuthorityPosting Veteran

    Quote Originally Posted by theface View Post
    ... I asked my doctor about the dosing of melatonin and he said he's instructed patients to take upwards of 15 mg of melatonin....
    Doses like that are quite large for melatonin, and are usually recommended for therapeutic purposes. Otherwise, regular doses range from about 500mcg or less to about 3mg or so. With melatonin, more is certainly not better!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
  25. New Member
    theface's Avatar
    Stats
    6'1"  201 lbs.
    Join Date
    Jun 2006
    Age
    30
    Posts
    345
    Rep Power
    274
    Level
    15
    Lv. Percent
    39.07%

    Quote Originally Posted by strategicmove View Post
    Doses like that are quite large for melatonin, and are usually recommended for therapeutic purposes. Otherwise, regular doses range from about 500mcg or less to about 3mg or so. With melatonin, more is certainly not better!
    Agreed, I was using his statemt to ease any fears of overdosing.
  26. New Member
    machine528's Avatar
    Join Date
    Mar 2007
    Posts
    402
    Rep Power
    33730
    Level
    18
    Lv. Percent
    81.5%

    I only take Melatonin when Im working Midnight shifts and during the winter months. Seems to keep me in a better mood during those brutally boring months of January, Feb and March.
  27. New Member
    bboyflash's Avatar
    Join Date
    Dec 2009
    Posts
    204
    Rep Power
    22902
    Level
    14
    Lv. Percent
    4.86%

    u wont have to take much melatonin cause the 5htp increases melatonin and hcg levels by itself
  28. New Member
    kidvik's Avatar
    Stats
    5'11"  185 lbs.
    Join Date
    Feb 2010
    Posts
    1
    Rep Power
    57
    Level
    1
    Lv. Percent
    0%

    Just ask the pharmacist when your there. That is what they are there for. I can tell you they will say it is ok and if you take too much you will just pee it out
  29. Elite Member
    bioman's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Sep 2003
    Age
    42
    Posts
    7,705
    Rep Power
    513136
    Level
    59
    Lv. Percent
    86.76%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    I take substantial doses of melatonin at night and have for years. Not addicted to it, nor do I have any sides from it. On the contrary, I feel pretty good on it. Pretty sure my pineal gland is fine and dandy. IMO, the melatonin that doesn't bind to the appropriate receptors is used as an antioxidant.

    5-htp I only take when I feel depression coming on...usually in the dead of winter. I have found that taking it first thing in the morning on an empty stomach get the most bang for the buck seratonin-wise. 50-100mg is more than enough for me, particularly used in combination with 50mg P-5-P. This combo definitely has a kick to it...in a good way.

    I would be way more cautious of overdosing 5-HTP than melatonin.
  30. New Member
    narraboth's Avatar
    Join Date
    Mar 2010
    Posts
    263
    Rep Power
    188
    Level
    13
    Lv. Percent
    73.28%

    i used melatonin to enhance sleep, 1mg, headache in the morning and still get up at the same time.
    i don't have problem fall asleep, but i have problem for waking too early.

    but if i use it for jetlag, no headache, good sleep, good drug for that.
  31. Senior Member
    lonewolf0420's Avatar
    Stats
    6'2"  223 lbs.
    Join Date
    May 2008
    Age
    36
    Posts
    2,314
    Rep Power
    1680
    Level
    34
    Lv. Percent
    64.98%
    Achievements Activity ProPosting Pro

    I never had an issue. taken 500mg of 5htp and 3mg of Melatonin. I've still been taking Melatonin, but I no longer taking 5htp do to taking St. Johns Wart.
  32. New Member
    PublicEnemy's Avatar
    Stats
    5'8"  150 lbs.
    Join Date
    Feb 2009
    Posts
    472
    Rep Power
    70167
    Level
    20
    Lv. Percent
    78.42%

    Correct me if I'm wrong, but wouldn't chronic supplementation of 5-HTP be suppressive to endogenous production?

    Or does it not operate on that kind of feedback loop?
  33. purebred
    Guest
    purebred's Avatar

    Quote Originally Posted by WannaBeHulk View Post
    i agree, 3 mg is a bit much. it has too long of a half life so i wake up feeling groggy everytime i take melatonin. i like theanine a couple hours before bed and tryptophan .5-1 hour before. works great in my experiences!
    how long of a half-life does melatonin have?
  34. New Member
    PublicEnemy's Avatar
    Stats
    5'8"  150 lbs.
    Join Date
    Feb 2009
    Posts
    472
    Rep Power
    70167
    Level
    20
    Lv. Percent
    78.42%

    how long of a half-life does melatonin have?
    30-50% Bioavailability and a 35-50 minute half life. My guess this is in part due to being a potent antioxidant.
  

  
 

Similar Forum Threads

  1. iforce intimidate and melatonin
    By drob14 in forum Supplements
    Replies: 24
    Last Post: 10-09-2012, 05:37 PM
  2. My fat loss stack (EC, Erase, 5HTP, and TT-33)
    By bigrobbierob in forum Supplements
    Replies: 17
    Last Post: 07-05-2012, 11:48 AM
  3. best time to take 5htp/dopa/melatonin?
    By comacho in forum Supplements
    Replies: 0
    Last Post: 10-08-2009, 08:46 PM
  4. plasmavol and melatonin
    By hulkinghitman in forum Supplements
    Replies: 0
    Last Post: 06-21-2007, 09:06 PM
  5. Gaba and Melatonin
    By CDB in forum Supplements
    Replies: 7
    Last Post: 03-13-2006, 05:01 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in