Nonrepinephrine affects on Fat Lipolysis

  1. New Member
    NeighbourMike's Avatar
    Stats
    6'2"  190 lbs.
    Join Date
    Oct 2012
    Posts
    95
    Rep Power
    326
    Level
    9
    Lv. Percent
    14.11%

    Nonrepinephrine affects on Fat Lipolysis


    I have a question, somewhat in relation to lecture today. In regards to lipolysis as we were discussing in class, what are the effects of SNDRI's (serotonin–norepinephrine–dopa mine reuptake inhibitor) on fat metabolism, during exercise and at rest. Is there any? I know nonrepinephrine has an effect on my fat liposylsis.

    Would Cymbalta (Duloxetine) 30mg be enough to actively affect this?

    I'm currently on a small dose...nothing serious and rest assured I am under medical supervision and I am weening off it slowly. Wondering if this has/would affect
    me trying to "lean up" as mentioned in class.

    Just a thought, I'm not going to flush it or anything neurotic, currently it's been a great help for me.

  2. Pro Virili Parte
    JudoJosh's Avatar
    Join Date
    Nov 2008
    Age
    29
    Posts
    8,918
    Rep Power
    2459710
    Level
    79
    Lv. Percent
    59.09%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Re: Nonrepinephrine affects on Fat Lipolysis


    I gained significent amount of weight on a low dose of lexapro (SSRI). N=1 I know but figured I would share

    Sent from my Samsung Galaxy S™II using Tapatalk 2
    "The only good is knowledge and the only evil is ignorance." - Socrates
  3. New Member
    NeighbourMike's Avatar
    Stats
    6'2"  190 lbs.
    Join Date
    Oct 2012
    Posts
    95
    Rep Power
    326
    Level
    9
    Lv. Percent
    14.11%

    Yeah, I think I read SNDRI's are N=3. so far I have been controlling every aspect of my nutrition including timing and nutrient delivery so I want to know if this is festooning my efforts somewhat if any.

    Whats the point of having your BCAAS/Hydrowhey immediately post workout, going for a 20 min anabolic HIIT sprints then eating carbs, all to control insulin levels to get maximum muscle protein uptake if this nonreprinephrine is ****ing me up.
    •   
       

  4. Senior Member
    ZiR RED's Avatar
    Stats
    6'1"  215 lbs.
    Join Date
    Aug 2010
    Posts
    2,529
    Rep Power
    297849
    Level
    43
    Lv. Percent
    42.16%
    Achievements Activity ProPosting Pro

    You are comparing a neurotransmittor to an adrenal hormone.

    The SNDRI is taken up by the brain and prevents the metabolism of NE in the neurons of the brain and CNS. It is not an NE agonist, and will not have a direct effect on lipolysis systemically.

    Most beta activation at fat cells is accomplished via epinephrine released into the blood stream and NE spillover from nerve terminals and the little that is released by the adrenal glands is not nearly as effective at increasing lipolysis as EPI. http://jcem.endojournals.org/content/91/2/665.abstract

    I think you need to look into the differences between intracerebral NE and NE reuptake inhibition compared to plasma/systemic NE before taking an SNDRI for performance.
  5. New Member
    NeighbourMike's Avatar
    Stats
    6'2"  190 lbs.
    Join Date
    Oct 2012
    Posts
    95
    Rep Power
    326
    Level
    9
    Lv. Percent
    14.11%

    I am not taking SNDRI for performance..that would be more than slightly disturbing.

    I am prescribed SNDRI, and was posing the question would it adequately disturb epinephrine level to skew fat loss in one way or another.

    Thanks for your advice, it is always good hearing the analysis from a qualified individual, I just was wondering from a chemical interaction perspective! Thanks
  6. Senior Member
    ZiR RED's Avatar
    Stats
    6'1"  215 lbs.
    Join Date
    Aug 2010
    Posts
    2,529
    Rep Power
    297849
    Level
    43
    Lv. Percent
    42.16%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by NeighbourMike View Post
    I am not taking SNDRI for performance..that would be more than slightly disturbing.

    I am prescribed SNDRI, and was posing the question would it adequately disturb epinephrine level to skew fat loss in one way or another.

    Thanks for your advice, it is always good hearing the analysis from a qualified individual, I just was wondering from a chemical interaction perspective! Thanks
    haha, yes it would...but never underestimate the things (stupid or otherwise) that people might do or try without giving it any thought or research.
  7. New Member
    NeighbourMike's Avatar
    Stats
    6'2"  190 lbs.
    Join Date
    Oct 2012
    Posts
    95
    Rep Power
    326
    Level
    9
    Lv. Percent
    14.11%

    Quote Originally Posted by ZiR RED View Post
    haha, yes it would...but never underestimate the things (stupid or otherwise) that people might do or try without giving it any thought or research.
    Understood and Granted!
    Haha as I begin to involve myself more & more in HWF Industry and expose myself to opportunity, there are many individuals who need to be properly facilitated in the RIGHT direction let me tell ya, that's about the nicest way I can say it.

    TLDR; Mirror Men, Curls for the girls etc
    PTAG-CPT, TSCC, ViPR
    Functional Training Hell Workout (An Offday/Cardio Workout!)
    http://anabolicminds.com/forum/workout-logs/223675-welcome-functional-training.html
  

  
 

Similar Forum Threads

  1. Replies: 4
    Last Post: 12-13-2008, 02:27 PM
  2. any ideas for the rookie on fat loss?
    By raudyboy3 in forum Weight Loss
    Replies: 0
    Last Post: 12-21-2005, 10:57 AM
  3. Will Benadryl affect Body Fat Measurements
    By twarder28 in forum Weight Loss
    Replies: 3
    Last Post: 07-19-2005, 11:55 AM
  4. Mdien affect on Cholesterol?
    By pcn in forum Anabolics
    Replies: 9
    Last Post: 02-22-2005, 09:20 AM
  5. Does Minoxidil have any affect on androgen levels?
    By Jeff Rippe in forum Cycle Info
    Replies: 3
    Last Post: 06-27-2003, 04:11 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in