AMNES1A Q&A
- 03-26-2018, 09:48 PM
- 04-05-2018, 07:11 AM
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- 04-05-2018, 09:10 AM
I just ordered two more bottles of AMNES1A yesterday....keeping the run going! I actually bought way too many other things as well. All necessities though...including 2 tubs of CU. I am not quite sure how long I will still be able to obtain that....had to grab some!
- 04-05-2018, 09:26 AM
- 04-05-2018, 09:36 AM
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- 04-12-2018, 08:08 AM
Anyone know if any of the ingredients might negatively interact with bupropion? I'd love to give Amnes1a a try (wake multiple times each night and have averaged 4-5 hours of sleep a night over the last few years). My doctor isn't very knowledgeable when it comes to supplements, so can't really get a good answer there. However, I would understand if this is a question that a rep (or anyone else) might be leery of answering.
- 04-12-2018, 09:26 AM
I do know that use of a Melatonin is not advised with an MAOI or SSRI. However, I believe Bupropion(Wellbutrin) is an NRDI and a bit different. A quick search didn’t list any specific interactions but further research is needed. I would pose this question to a Pharmacologist.
- 04-12-2018, 09:33 AM
- 04-12-2018, 10:17 AM
Cool. There’s a few on here. Can’t remember exactly who. @2kvette might be in that field IIRC?
- 04-12-2018, 07:31 PM
Hey, bupropion works through dopamine and norepi reuptake inhibition. Human receptor binding shows 5-HT receptor inhibition at around 2%. So 5-HT supplements are not likely to be a big deal. Now, this stuff has a lot of herbal products in it which are very difficult to find receptor binding assays on. So I can't speak to what the effects of each ingredient would be without really doing some in depth research on substances that may or may have not been appropriately studied.
BUT! I will say this, the buproprion is likely whats keeping you awake at night. It's one of the most common side effects, and I almost expect everyone who is on it to experience it in some form. - 04-12-2018, 08:30 PM
Thanks for the info. I'll read up more on all the ingredients to make sure there are no interactions. Unfortunately, the problem isn't the Bupropion as I just started taking it a couple months ago and have had issues with sleep for years (no better, no worse since starting Bupropion). However, if I do take the second dose (150 mg sr) in the afternoon, then sleep is definitely worse (which is why I stick with just a single morning dose).
- 04-12-2018, 08:43 PM
- 04-12-2018, 10:11 PM
Thank you for the suggestions. Have been taking 12.5-25 mg benadryl many nights (which helps some) but will check out doxylamine. Also, I don't take stims...can't tolerate them. Will stay clear of ambien (mom and brother take it and both have commented on it not working as well over time and other issues). Thanks again.
- 04-13-2018, 12:05 PM
- 04-13-2018, 01:20 PM
- 04-13-2018, 01:51 PM
Yeah, that's the problem I have when taking benadryl. I don't get enough hours due to what's become normal insomnia and kids waking me when I do finally fall asleep. So, I'm always groggy when I do wake up. L-theanine helps too but no matter what I take, I'll still wake up 2 or 3 hours later and have trouble getting back to sleep. I have to then take more stuff to knock me out again...which carries into the next morning causing grogginess. That's why I'm looking at Amnes1a. Seems like a great formula that should help with the quality of sleep I get (even when woken multiple times by the kids). Just want to be careful with any possible interaction with my meds.
- 04-13-2018, 04:47 PM
- 04-13-2018, 08:26 PM
- 04-13-2018, 10:01 PM
- 04-14-2018, 01:34 AM
Not really, they’re about the same. But diphenhydramine seems to be more susceptible to genetetic polymorphism in p450’s. Especially with 2D6. That’s why the half life ranges is so wild, from 2hr to 18hr. I haven’t seen as many people complain of doxylamien making them groggy.
- 04-14-2018, 06:04 AM
Black Lion Research Rep - 04-14-2018, 01:51 PM
- 04-14-2018, 02:16 PM
- 04-15-2018, 10:11 AM
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